Publications by authors named "Roohi Aslam"
Article Synopsis
- Tamoxifen is the primary hormonal therapy for hormone receptor-positive breast cancers, but its effectiveness is limited by low bioavailability due to metabolic processes in the liver and intestines.
- Researchers developed a method using iron oxide nanoparticles (synthesized from green tea extract and stabilized with agar) to improve tamoxifen delivery and increase its bioavailability.
- The resulting tamoxifen-conjugated nanoparticles showed a high entrapment efficiency of 88% and effectively killed breast cancer cells in tests, indicating their potential for better cancer treatment.
Plants require copper for normal growth and development and have evolved an efficient system for copper management based on transport proteins such as P-ATPases, also known as heavy metal ATPases (HMAs). Here, we report HMAs in eleven different Poaceae species, including wheat. Furthermore, the possible role of wheat HMAs in copper stress was investigated.
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- Breast cancer is a leading cause of illness and death among women, prompting research into potential viral links, specifically with bovine leukemia virus (BLV).
- A study analyzed 2,710 breast cancer samples, revealing that 26.8% contained BLV genes, compared to 10% in control samples without cancer.
- The findings indicate a potential association between BLV and breast cancer, highlighting the need for monitoring cattle and dairy products to minimize human exposure.
Transcription factors are regulatory proteins known to modulate gene expression. These are the critical component of signaling pathways and help in mitigating various developmental and stress responses. Among them, bZIP, BBR, and BZR transcription factor families are well known to play a crucial role in regulating growth, development, and defense responses.
View Article and Find Full Text PDFBackground: Arisaema jacquemontii is traditionally used in treatment of different diseases. In this study, phytochemical, in vitro biological and chemo-preventive screening of A. jacquemontii was carried out to explore its pharmacological potential.
View Article and Find Full Text PDFBackground: P- type calcium ATPases (ACAs-auto inhibited calcium ATPases and ECAs-endoplasmic reticulum calcium ATPases) belong to the P- type ATPase family of active membrane transporters and are significantly involved in maintaining accurate levels of Ca, Mn and Zn in the cytosol as well as playing a very important role in stress signaling, stomatal opening and closing and pollen tube growth. Here we report the identification and possible role of some of these ATPases from wheat.
Results: In this study, ACA and ECA sequences of six species (belonging to Poaceae) were retrieved from different databases and a phylogenetic tree was constructed.