Small-molecule disruption of androgen receptor-dependent chromatin clusters.

Sustained androgen receptor (AR) signaling during relapse is a central driver of metastatic castration-resistant prostate cancer (mCRPC). Current AR antagonists, such as enzalutamide, fail to provide long-term benefit for the mCRPC patients who have dramatic increases in AR expression. Here, we report AR antagonists with efficacy in AR-overexpressing models.

Clinical Characteristics, Transmission Rate and Outcome of Neonates Born to COVID-19-Positive Mothers: A Prospective Case Series From a Resource-Limited Setting.

Background: Coronavirus disease (COVID-19) infection during pregnancy could damage the placenta, but data on neonates born to COVID-19-positive mothers is scarce. In this case series, we aim to describe clinical characteristics, transmission rate and outcomes at 3 months of age among neonates born to mothers with COVID-19 diagnosed near the time of delivery.

Methods: Prospective, multicenter case series from Suriname.

Use of Direct-to-Consumer Telemedicine to Access Mental Health Services.

Background: The coronavirus disease 2019 pandemic has contributed to growing demand for mental health services, but patients face significant barriers to accessing care. Direct-to-consumer(DTC) telemedicine has been proposed as one way to increase access, yet little is known about its pre-pandemic use for mental healthcare.

Objective: To characterize patients, providers, and their use of a large nationwide DTC telemedicine platform for mental healthcare.

Identifying low-PM exposure commuting routes for cyclists through modeling with the random forest algorithm based on low-cost sensor measurements in three Asian cities.

Cyclists can be easily exposed to traffic-related pollutants due to riding on or close to the road during commuting in cities. PM has been identified as one of the major pollutants emitted by vehicles and associated with cardiopulmonary and respiratory diseases. As routing has been suggested to reduce the exposures for cyclists, in this study, PM was monitored with low-cost sensors during commuting periods to develop models for identifying low exposure routes in three Asian cities: Taipei, Osaka, and Seoul.

Direct Synthesis of Nanosheet-Stacked Hierarchical "Honey Stick-like" MFI Zeolites by an Aromatic Heterocyclic Dual-Functional Organic Structure-Directing Agent.

Soft template designing is the most promising strategy for the synthesis of zeolite nanosheets. MFI nanosheets directed by soft templates (containing long-chain alkyl groups or aromatic groups as hydrophobic component) can be found frequently; however, so far, MFI nanosheets synthesized by soft templates with aromatic heterocycle groups (e. g.

The Association Between Physician Race/Ethnicity and Patient Satisfaction: an Exploration in Direct to Consumer Telemedicine.

Background: Patient satisfaction measures have important implications for physicians. Patient bias against non-White physicians may impact physician satisfaction ratings, but this has not been widely studied.

Objective: To assess differences in patient satisfaction by physician race/ethnicity.

Biomimetic fabrication of highly ordered laminae-trestle-laminae structured copper aero-sponge.

Light-weight metallic aero-sponges are highly desirable for electronics, energy storage, catalysis and environmental remediation. Although several fabrication methods have been developed, the mechanical strength and the structural fatigue resistance of the metallic aero-sponges remain unsatisfactory. Loofah sponge is known for its mechanical strength and grease absorption due to its highly ordered hierarchical laminae-trestle-laminae (L-T-L) microstructure.

Multi-Arch-Structured All-Carbon Aerogels with Superelasticity and High Fatigue Resistance as Wearable Sensors.

Compressible and ultralight all-carbon materials are promising candidates for piezoresistive pressure sensors. Although several fabrication methods have been developed, the required elasticity and fatigue resistance of all-carbon materials are yet to be satisfied as a result of energy loss and structure-derived fatigue failure. Herein, we present a two-stage solvothermal freeze-casting approach to fabricate all-carbon aerogel [modified graphene aerogel (MGA)] with a multi-arched structure, which is enabled by the in-depth solvothermal reduction of graphene oxide and unidirectional ice-crystal growth.

Corticosteroid Use for Acute Respiratory Tract Infections in Direct-to-Consumer Telemedicine.

Background: Systemic corticosteroids are not indicated for acute respiratory tract infections yet are nonetheless prescribed in outpatient care. Acute respiratory tract infections are the most common diagnosis in direct-to-consumer telemedicine. The objective of this study was to characterize use of corticosteroids for acute respiratory tract infections in this setting and to assess the association between corticosteroid receipt and patient satisfaction.

Management of Urinary Tract Infections in Direct to Consumer Telemedicine.

Background: Urinary tract infections (UTI) are a common reason for seeking care via direct to consumer (DTC) telemedicine, yet patterns of care, including antibiotic prescribing, have not been reported.

Objective: To describe management of UTI in a large nationwide DTC telemedicine platform.

Design: Cross-sectional observational study.

Mercury adsorption and re-emission inhibition from actual WFGD wastewater using sulfur-containing activated carbon.

A series of batch experiments were conducted to obtain the optimal adsorption condition for removing aqueous Hg from actual lime-based wet flue gas desulfurization (WFGD) wastewater with sulfur-containing activated carbon (SAC). The experimental results showed that SAC1 had an average 0.32 μg mg larger aqueous Hg adsorption capacity and 21% larger Hg removal than the CS-treated SAC1 (i.

Nitrogen and Sulfur Co-Doped Graphene Nanosheets to Improve Anode Materials for Sodium-Ion Batteries.

Sodium-ion batteries (SIBs) attract more attention because of sodium's abundant availability, affordable price, and potential to be an effective anode material. Meanwhile, carbon-based materials provide the most promising anode materials. Because of the large radius of sodium ions, SIBs do not exhibit favorable electrochemical performance.

Association Between Antibiotic Prescribing for Respiratory Tract Infections and Patient Satisfaction in Direct-to-Consumer Telemedicine.

This study assesses the association between antibiotic prescribing for respiratory tract infections and satisfaction ratings among patients using a direct-to-consumer telemedicine platform.

Patterns of Use and Correlates of Patient Satisfaction with a Large Nationwide Direct to Consumer Telemedicine Service.

Background: Despite its rapid expansion, little is known about use of direct to consumer (DTC) telemedicine.

Objective: To characterize telemedicine patients and physicians and correlates of patient satisfaction DESIGN: Cross-sectional study PARTICIPANTS: Patients and physicians of a large nationwide DTC telemedicine service MAIN MEASURES: Patient characteristics included demographics and whether or not they reported insurance information. Physician characteristics included specialty, board certification, and domestic versus international medical training.

Promoter effect of heteroatom substituted AlPO-11 molecular sieves in hydrocarbons cracking reaction.

It is important to develop new promoters of fluid catalytic cracking (FCC) catalyst to increase iso-paraffin yield and avoid the decrease of research octane number (RON) caused by olefin saturation in gasoline hydrofining. SAPO-11 and LaAPO-11 molecular sieves were used as promoters to FCC catalyst to increase gasoline RON and were tested in the cracking reaction of n-dodecane on FCC conditions. LaAPO-11 molecular sieve has less and weaker acidity than SAPO-11 molecular sieve.

Lidar equation inversion methods and uncertainties in measuring fugitive particulate matter emission factors.

Measurements from two field campaigns that employed a micropulse lidar are used to compare the near-end and the far-end lidar equation inversion methods for estimating emission factors (EFs) of particulate matter (PM) from three types of anthropogenic fugitive sources: vehicles moving on unpaved roads, open burning, and open detonation. As optical depth increased from 0 to 2, relative EF uncertainty increased from 54% to 300% using the near-end method and decreased from 69% to 42% using the far-end method. To the best of our knowledge, this research is the first to use field measurements to compare results from these methods for anthropogenic PM plumes and quantify their uncertainties.

Technical data for concentrated solar power plants in operation, under construction and in project.

This article presents technical data for concentrated solar power (CSP) plants in operation, under construction and in project all over the world in the form of tables. These tables provide information about plants (e.g.

Projections of NH emissions from manure generated by livestock production in China to 2030 under six mitigation scenarios.

China's rapid urbanization, large population, and increasing consumption of calorie-and meat-intensive diets, have resulted in China becoming the world's largest source of ammonia (NH) emissions from livestock production. This is the first study to use provincial, condition-specific emission factors based on most recently available studies on Chinese manure management and environmental conditions. The estimated NH emission temporal trends and spatial patterns are interpreted in relation to government policies affecting livestock production.

Monitoring and Control of an Adsorption System Using Electrical Properties of the Adsorbent for Organic Compound Abatement.

Adsorption systems typically need gas and temperature sensors to monitor their adsorption/regeneration cycles to separate gases from gas streams. Activated carbon fiber cloth (ACFC)-electrothermal swing adsorption (ESA) is an adsorption system that has the potential to be controlled with the electrical properties of the adsorbent and is studied here to monitor and control the adsorption/regeneration cycles without the use of gas and temperature sensors and to predict breakthrough before it occurs. The ACFC's electrical resistance was characterized on the basis of the amount of adsorbed organic gas/vapor and the adsorbent temperature.

germline variants in early-onset breast cancer patients from hereditary breast and ovarian cancer families.

, located 470 kb downstream of , encodes for the nuclear PSMC3-interacting protein, which functions as co-activator of steroid hormone-mediated gene expression, and is involved in RAD51 and DMC1-mediated homologous recombination during DNA repair of double-strand breaks. Recently, germline variants in have been identified in hereditary breast and ovarian cancer (HBOC) patients, mainly in cases with early-onset. We screened a cohort of 166 mutation-negative HBOC patients, of which 56 developed early-onset breast cancer before the age of 36 years, for variants.

Obtaining control of cell surface functionalizations via Pre-targeting and Supramolecular host guest interactions.

The use of mammalian cells for therapeutic applications is finding its way into modern medicine. However, modification or "training" of cells to make them suitable for a specific application remains complex. By envisioning a chemical toolbox that enables specific, but straight-forward and generic cellular functionalization, we investigated how membrane-receptor (pre)targeting could be combined with supramolecular host-guest interactions based on β-cyclodextrin (CD) and adamantane (Ad).