Publications by authors named "Ronwyn Cartwright"
Cold agglutinin disease (CAD) causes predominantly extravascular hemolysis and anemia via complement activation. Sutimlimab is a novel humanized monoclonal antibody directed against classical pathway complement factor C1s. We aimed to evaluate the safety and efficacy of long-term maintenance treatment with sutimlimab in patients with CAD.
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- National antenatal screening for pregnant women in England follows guidelines from the NHS Sickle Cell and Thalassaemia Screening Programme to identify beta thalassaemia carriers.
- The screening uses specific criteria based on two lab values: percentage Hb A2 and mean corpuscular haemoglobin (MCH).
- In a study of 59,500 samples, the action criteria were validated, showing very few false positives (25) and false negatives (9), reinforcing the effectiveness of the current screening values.