Publications by authors named "Ronny Vargas"
Article Synopsis
- - The Blood-Brain Barrier (BBB) makes it difficult for drugs to reach the central nervous system, but nanotechnology, particularly lipid nanoparticles with surface modifications, shows promise in improving drug delivery.
- - A systematic review analyzed 2041 articles, identifying 80 relevant studies which highlighted that peptides are the most common modification for enhancing BBB permeability, followed by mixed strategies and proteins.
- - Key findings indicated that factors like nanoparticle type, size (preferably under 150 nm), and functionalization strategy significantly influence drug delivery efficiency, underscoring the need for standardized testing methods to guide future research in this area.
Cationic solid-lipid nanoparticles (cSLNs) have become a promising tool for gene and RNA therapies. PEGylation (PEG) is crucial in enhancing particle stability and protection. We evaluated the impact of PEG on the physicochemical and biological characteristics of cholesteryl-oleate cSLNs (CO-cSLNs).
View Article and Find Full Text PDFResearch on alternatives to the use of animal models and cell cultures has led to the creation of organ-on-a-chip systems, in which organs and their physiological reactions to the presence of external stimuli are simulated. These systems could even replace the use of human beings as subjects for the study of drugs in clinical phases and have an impact on personalized therapies. Organ-on-a-chip technology present higher potential than traditional cell cultures for an appropriate prediction of functional impairments, appearance of adverse effects, the pharmacokinetic and toxicological profile and the efficacy of a drug.
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