Chitosan-based self-assembled nanocarriers coordinated to cisplatin for cancer treatment.

Polymeric nanocarriers were prepared a dialysis method using three chitosan derivatives, -benzyl-,-succinyl chitosan (BSCT), -naphthyl-,-succinyl chitosan (NSCT), and -octyl--succinyl chitosan (OSCT) and were coordinated to cisplatin. The nanocarrier properties and cytotoxicity on the human carcinoma cells, HN22 (head and neck), were investigated. In addition, intracellular cisplatin accumulation, apoptosis induction and toxicity on renal cells were also evaluated.