Publications by authors named "Ronny Malz"
Introduction: Myocarditis is induced by coxsackievirus B3 (CVB3). Myocardial inflammation is tied to the activation of coagulation. Coagulation factor (F) Xa, a central player in coagulation, activates matrix metalloproteinases (MMP), which modulate the remodeling.
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- Coagulation plays a key role in the immune response by limiting pathogen spread, with proteases like thrombin activating cells through specific receptors (PARs).
- In a study on coxsackievirus B3 (CVB3) and influenza A infections, mice without PAR-1 showed higher viral loads and more heart damage than those with PAR-1, indicating its protective role.
- The research highlights that the interaction between PAR-1 and TLR3 in cardiac cells boosts immune responses, such as the production of important proteins like IFN-β and CXCL10, which are crucial during viral infections.
Background: Tissue factor (TF) is expressed in 2 isoforms: membrane-bound "full length" (fl)TF and soluble alternatively spliced (as)TF. flTF is the major thrombogenic form of TF. Although the function of asTF is poorly understood, it was suggested that asTF contributes to tumor-associated growth and angiogenesis.
View Article and Find Full Text PDFBackground: Tissue factor (TF) is the primary initiator of blood coagulation. In response to tumor necrosis factor (TNF)-alpha human umbilical vein endothelial cells (HUVECs) express 2 TF isoforms: a soluble alternatively spliced isoform (asHTF) and membrane-bound "full length" (fl)TF. How the differential TF isoform expression is regulated is still unknown.
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