Publications by authors named "Ronny Kaufmann"
Article Synopsis
- Changes in DNA methylation patterns contribute significantly to the aging process in human skin, affecting gene expression and skin functionality.
- Researchers screened a large library of substances and found that dihydromyricetin (DHM), a natural antioxidant, effectively inhibits the DNA methyltransferase DNMT1, which is involved in maintaining these patterns.
- Treatment with DHM resulted in noticeable changes in DNA methylation, leading to a reduction in biological age and improvements in gene activation and skin thickness in experimental models.
Statistical analysis plays a fundamental part in the evaluation of mutagenicity experiments. However, a statistically significant or non-significant test result without incorporating the biological relevance cannot be a valid scientific criterion for concluding a positive or negative effect of the underlying compound (Hauschke et al., 1997).
View Article and Find Full Text PDF