Publications by authors named "Ronnie Shapira-Fromer"
Adoptive cell transfer (ACT) using autologous tumor infiltrating lymphocytes (TILs) was previously shown to yield clinical response in metastatic melanoma patients as an advanced line. Unfortunately, there is no reliable marker for predicting who will benefit from the treatment. We analyzed TIL samples from the infusion bags used for treatment of 57 metastatic melanoma patients and compared their microRNA profiles.
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- - The study reveals that the RNA editing protein ADAR1 is down-regulated during the metastatic transition of melanoma, which increases melanoma cell growth and tumor characteristics.
- - Knockdown of ADAR1 in melanoma cells leads to resistance against tumor infiltrating lymphocytes, indicating a significant role for ADAR1 in melanoma immune resistance through its effect on miR-222 and ICAM1 expression.
- - Higher levels of miR-222 in melanoma tissues correlate with poor clinical response to the drug ipilimumab, suggesting miR-222 could serve as a biomarker to predict treatment outcomes and inform personalized therapy.