Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine.

New daily persistent headache is a continuous, unremitting headache, notorious for its unresponsiveness to aggressive medical interventions. The underlying pathophysiology of new daily persistent headache is poorly understood resulting in unending, chronic pain. However, a prior study identified elevated tumor necrosis factor alpha within the cerebral spinal fluid of new daily persistent headache patients.

Ethanol modifies zebrafish responses to abrupt changes in light intensity.

Zebrafish exhibit a preference for dark areas and this behavior has been used to characterize anxiety. Their responses to light may also be modified by ethanol. Using high-speed video recordings, we demonstrated that untreated animals were relatively more active immediately after a bright-dim transition compared to animals exposed to low dose ethanol (2%).