Publications by authors named "Ronnie Gonen"
J Biol Chem
February 2007
Article Synopsis
- PLC-gamma1 activation in T cells requires a protein complex including LAT, Gads, and SLP-76, especially after T cell receptor stimulation.
- The recruitment of PLC-gamma1 to lipid rafts, or GEMs, depends on SLP-76, particularly its Gads-binding domain, although SLP-76's N-terminal sites are not needed for this recruitment.
- SLP-76 also plays a crucial role in facilitating PLC-gamma1 phosphorylation at Tyr(783) through its interactions with other signaling proteins like Vav and ITK, highlighting its importance in T cell signaling.
Article Synopsis
- * The study reveals a paradox where the essential P-I region of SLP-76, though critical for TCR-induced activation of PLC-gamma1, does not require any specific part for full functionality.
- * Mutant forms of SLP-76 show that interaction with SH3(PLC) is not necessary for activating PLC-gamma1, indicating that the P-I region has a structural role rather than one strictly based on binding interactions.
