Publications by authors named "Ronni Mikkelsen"

In this Neuro-Interventional Video, we demonstrate a novel Augmented Reality (AR) platform for visualising vascular imaging data during interventional procedures. The platform allows clinicians to interact with 3D patient data through head-mounted displays while remaining sterile. Our workflow converts rotational angiography data to 3D models in real-time, and enables intuitive hand-tracked manipulation of patient data, including tools for cropping, size measurement, and C-arm projection assessment.

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Article Synopsis
  • Pediatric idiopathic intracranial hypertension (IIH) is a rare condition with unknown causes, and this study investigated whether increased systemic or cerebral venous pressure might play a role in its development.
  • The study involved 11 prepubertal children who underwent various tests, including MRI and pressure monitoring, showing all had elevated venous pressures, but only one had specific venous stenosis while others had normal anatomy.
  • The findings suggest that increased systemic venous pressure could be linked to prepubertal IIH, highlighting a need for pediatric-specific diagnostic criteria and further research to understand and treat this condition better.
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Article Synopsis
  • - The TENSION trial evaluated the long-term safety and effectiveness of endovascular thrombectomy for patients with ischemic stroke and large infarcts, demonstrating favorable outcomes at 90 days, with a follow-up extending to 12 months.
  • - Conducted across various hospitals in Europe and Canada, the trial involved patients aged 18 and older with acute ischemic strokes caused by large vessel occlusions, comparing results between those receiving thrombectomy plus medical care versus medical care alone.
  • - Out of 253 enrolled patients, results indicated significant insights into functional outcomes, quality of life, and mental health aspects like anxiety and depression, although the trial concluded early due to promising efficacy in the treatment group.
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Introduction: Here, we describe a rare case of a spinal arteriovenous fistula in a patient with known hereditary hemorrhagic telangiectasia (HHT) and spontaneous intraspinal hemorrhage. Furthermore, we provide a brief review of the literature on the formation of spinal arteriovenous malformations (AVM) in relation to this disease.

Case Presentation: The case involves a 54-year-old male with known HHT.

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Background: Recent evidence suggests a beneficial effect of endovascular thrombectomy in acute ischaemic stroke with large infarct; however, previous trials have relied on multimodal brain imaging, whereas non-contrast CT is mostly used in clinical practice.

Methods: In a prospective multicentre, open-label, randomised trial, patients with acute ischaemic stroke due to large vessel occlusion in the anterior circulation and a large established infarct indicated by an Alberta Stroke Program Early Computed Tomographic Score (ASPECTS) of 3-5 were randomly assigned using a central, web-based system (using a 1:1 ratio) to receive either endovascular thrombectomy with medical treatment or medical treatment (ie, standard of care) alone up to 12 h from stroke onset. The study was conducted in 40 hospitals in Europe and one site in Canada.

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Purpose: Cadaver dissections and X-ray based 3D angiography are considered gold standards for studying neurovascular anatomy. We sought to develop a model that utilize the combination of both these techniques to improve current tools for anatomical research, teaching and preoperative surgical planning, particularly addressing the venous system of the brain.

Materials And Methods: Seven ethanol-fixed human cadaveric heads and one arm were injected with a latex-barium mixture into the internal jugular veins and the brachial artery.

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Background: We present a case illustrating evolution of symptoms and brain magnetic resonance imaging in cortical superficial siderosis.

Case Presentation: A 74-year-old man with no prior medical history presented with transient focal neurological episodes with subtle imaging changes. There was no evidence of cortical superficial siderosis.

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Idiopathic intracranial hypertension (IIH) is characterised by intractable headache, papilloedema, visual symptoms, pulsatile tinnitus and elevated intracranial pressure (ICP). The incidence has increased, most likely due to the simultaneous increase in obesity. This review finds that imaging is centered on ruling out structural causes of elevated ICP as well as visualising classical signs of IIH.

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In this case report, a nine-year-old girl was seen in the emergency department due to neck pain following a trampoline accident ten days ago. She had experienced paraesthesia in her left arm immediately after the accident, but these symptoms disappeared during the first day. A CT scan of the cervical spine was found to be normal.

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Introduction: This study sought to expand the very limited data on Scandinavian paediatric poly-trauma patients by charactering patients from this population admitted to a Danish level-1 trauma centre.

Methods: This retrospective cohort study included all patients 15 years or younger who were admitted to the trauma centre at Aarhus University Hospital, Denmark from January 2000 to May 2014. Injury severity was calculated using the Injury Severity Score (ISS).

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Background And Purpose: Reducing radiation exposure to the temporal lobes could be beneficial to preserve cognitive function in paediatric brain tumour patients. The distribution of doses to brain substructures associated with cognition (BSCs) both within and outside of the temporal lobe have not been reported. The aim of this study was therefore to investigate temporal lobe sparing photon vs.

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Background: The ability to achieve hemostasis after spontaneous subarachnoid hemorrhage (SAH) plays a pivotal role in outcome. Changes in coagulation in the early hours after SAH have been only sparsely investigated.

Objective: To investigate changes in coagulation after SAH and illuminate underlying mechanisms.

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Several brain substructures associated with cognition (BSCs) are located close to typical pediatric brain tumors. Pediatric patients therefore have considerable risks of neurocognitive impairment after brain radiotherapy. In this study, we investigated the radiation doses received by BSCs for three common locations of pediatric brain tumor entities.

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Considering the changes in moral principles, human behavior and behavioral values through the ages, in Egill Skallagrimsson's Saga, Egill presents us with altered mental status. This is in terms of what at present is considered symptoms of an anti-social personality, and bipolar affective disorder. Egill Skallagrimsson is considered one of the most famous Vikings in the Icelandic Sagas.

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Purpose Repeat imaging in patients with non-aneurysmal subarachnoid hemorrhage (NASAH) remains controversial. We aim to report our experience with NASAH with different hemorrhage patterns, and to investigate the need for further diagnostic workup to determine the underlying cause of hemorrhage. Method We conducted a retrospective analysis of all spontaneous SAH with an initial negative computed tomography (CT) with angiography (CTA) and/or digital subtraction angiography (DSA) from October 2011 through May 2017.

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BACKGROUND Chronic subdural hematoma (CSDH) is a common neurosurgical condition that is treated using a cranial burr hole evacuation procedure, but recurrence is common. The use of anticoagulant therapy can increase the risk of developing a recurrent subdural hematoma. We present a challenging case of a patient on long-term anticoagulant therapy following previous aortic and aortic valve surgery who had CSDH with multiple recurrences and was ultimately treated with tranexamic acid as an adjunct to surgery.

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Objective: To study if the public is able to recognise and understand the International Liaison Committee on Resuscitation (ILCOR) sign for automated external defibrillators (AEDs), and to explore how national resuscitation councils have adopted the sign.

Methods: A survey was conducted among travellers in an international airport serving 21 million passengers annually. Participants were asked to state the meaning of six international safety signs, one of which was the ILCOR AED sign.

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Background: Vertebral artery (VA) dissection (VAD) has been described following neck injury and can be associated with stroke, but the causal association with cervical spine manipulation therapy (cSMT) is controversial. The standard treatment for VAD is antithrombotic medical therapy. To highlight the considerations of an endovascular approach to VAD, we present a critical case of bilateral VAD causing embolic occlusion of the basilar artery (BA) in a patient with symptom debut following cSMT.

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Introduction: Knowledge of trauma patients is often based on US studies. However, these may not be representative of the Scandinavian population. Knowing which trauma patients are at risk of dying might help us target and optimise their treatment.

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