Publications by authors named "Ronit Friling"
Article Synopsis
- The study focuses on infants with isolated congenital sixth nerve palsy (ICSNP), detailing a case series and proposing a management algorithm based on their findings.
- Researchers reviewed the records of six patients diagnosed with ICSNP from January 2020 to November 2022, noting their birth details, symptoms, and outcomes.
- Results suggested that ICSNP typically resolves within 1 to 3 months without significant underlying issues, supporting the idea of a straightforward initial assessment with follow-ups if necessary.
Background: This study aims to examine the rare entity of unilateral macular lesions in the pediatric population and describe the distinct diagnoses and characterizations related to these findings.
Methods: A retrospective cohort design. The database of the ophthalmology clinic in a tertiary medical center was reviewed to identify all children with incidental unilateral macular findings, examined during 2016 through 2021.
Risk factors for the development of macular edema in children with uveitis.
Front Ophthalmol (Lausanne)
June 2023
Aim: To determine the risk factors for macular edema (ME) in children with uveitis.
Methods: A retrospective study was conducted of 150 pediatric patients (264 eyes) with uveitis attending 2 tertiary medical centers. Data were collected from the medical files on demographics, type of uveitis, etiology, clinical findings, treatment, and time to development of ME.
Article Synopsis
- The study investigates how the COVID-19 lockdown in Israel impacted the number and nature of ophthalmic consultations in a pediatric emergency department (PED) from March to April 2020, comparing it with the same period in 2019.
- Findings revealed a 52% decrease in PED visits during the lockdown, with a shift towards younger patients (ages 1-5) and later visit times, and notable changes in trauma patterns, including more sharp injuries occurring at home.
- The authors recommend that parents be educated on injury prevention and treatment, and suggest increasing the use of telemedicine and senior physician consultations in pediatric ophthalmic care during crises like pandemics.
Functional and Structural Findings in Infants Treated for Retinopathy of Prematurity Using Optical Coherence Tomography Angiography.
Ophthalmic Surg Lasers Imaging Retina
April 2022
Article Synopsis
- The study aimed to evaluate the foveal microvascular structure in children who had retinopathy of prematurity (ROP) and were treated with diode laser photocoagulation, utilizing optical coherence tomography angiography (OCTA).
- The research involved 17 children with a history of ROP and compared their OCTA results to those of 12 healthy controls, finding significant differences in several parameters.
- Key findings included a smaller foveal avascular zone and lower vascular density in the ROP group, indicating that OCTA can reveal important long-term changes in macular structures for these patients.
: To report cases of uveitis induced by biological therapy given for cancer.: Retrospective review of medical charts of patients.: Included were six patients aged 14-81 years.
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- Acute acquired comitant esotropia (AACE) is a rare form of eye misalignment in children, which may suggest underlying neurological issues, although the actual risk is unclear, especially when other symptoms aren't present.
- The study examined 20 children with AACE, ages 4 and up, ensuring they had no additional neurological or eye problems; the majority (95%) showed normal brain imaging results.
- The findings indicate that AACE in otherwise healthy children is likely not linked to severe brain issues, suggesting that neuroimaging may be unnecessary in cases without accompanying concerns, while monitoring preferences of caregivers should also be considered.
Article Synopsis
- The study aimed to investigate how reduced contrast sensitivity impacts three common color vision tests, which could have implications for clinical practices.
- Researchers tested color vision using the Ishihara and Hardy-Rand-Rittler (H-R-R) plates and the Farnsworth D-15 arrangement test under varying levels of contrast sensitivity.
- Findings indicate that while the tests perform similarly at high contrast levels, the H-R-R and Farnsworth D-15 tests show significantly higher error rates compared to the Ishihara test when contrast sensitivity is lower.
Purpose: To investigate the clinical course and visual outcome of macular edema (ME) in pediatric patients with chronic noninfectious uveitis.
Design: Retrospective case series.
Methods: The databases of the uveitis clinics of 4 tertiary medical centers in Israel and the UK were searched for all children treated for uveitic ME in the years 2005-2015.
Article Synopsis
- The study aimed to compare how ocular motility deviation in strabismus patients changed using cycloplegic eye drops versus a prism adaptation test.
- Data was collected from 43 patients who had strabismus surgery, focusing on 33 with exotropia, measuring motility deviation at various times during the tests.
- Results showed that prism adaptation was statistically more effective than cycloplegic drops at assessing motility both during the tests and shortly after, making it the preferred method for pre-surgical evaluation.
The effect of anti-tumor necrosis factor alpha agents on the outcome in pediatric uveitis of diverse etiologies.
Graefes Arch Clin Exp Ophthalmol
April 2018
Article Synopsis
- This study evaluated the outcomes of children with uveitis treated with anti-TNF-α agents (infliximab and adalimumab) after failing standard immunosuppressive therapy.
- The cohort consisted of 24 patients, with a common diagnosis of juvenile idiopathic arthritis-related uveitis, and the study tracked their visual acuity and ocular complications over time.
- Results showed a trend of improvement in visual acuity post-treatment and significant corticosteroid-sparing effects, suggesting the need for further research into using anti-TNF-α agents as a first-line treatment for pediatric uveitis.
Article Synopsis
- The study investigates the incidence of horizontal misalignment that requires surgery in children with congenital Brown syndrome, based on medical records from a specific medical center over 18 years.
- Among the 16 patients studied, most (88%) underwent surgery to correct compensatory head positions, with a notable portion also having primary position horizontal deviations.
- Post-surgery results showed a significant reduction in horizontal deviation, highlighting the need for addressing this issue during surgical intervention for congenital Brown syndrome.
Purpose: To determine the risk factors for the development of cataract in children with uveitis of any etiology.
Design: Cohort study.
Methods: Two hundred forty-seven eyes of 140 children with uveitis were evaluated for the development of vision-affecting cataract.
Uveitic Glaucoma: Long-term Clinical Outcome and Risk Factors for Progression.
Ocul Immunol Inflamm
December 2017
Purpose: To study the long-term clinical outcomes of uveitic glaucoma and to identify risk factors for progression.
Methods: Retrospective study of uveitic glaucoma patients in two tertiary medical centers in 2003-2015. Patient- and disease-related data was retrieved.
Medical And Surgical Management Of Orbital Cellulitis In Children.
Folia Med (Plovdiv)
December 2015
Objective: The purpose of this study was to identify features of orbital cellulitis that predict response to conservative treatment without surgical intervention and factors associated with a decision for surgery.
Patients And Methods: The medical files of patients diagnosed with orbital cellulitis at a tertiary medical center in central Israel between 1995 and 2010 were reviewed for clinical data, diagnosis, complications, and type of treatment. Comparison was made between patients treated with antibiotics and patients treated with antibiotics and surgery.
Article Synopsis
- Retinopathy of prematurity (ROP) is a condition in premature babies that can cause severe vision loss due to abnormal eye blood vessel development.
- A study used B-scan ocular ultrasonography to assess the superior ophthalmic vein (SOV) in premature infants, comparing those diagnosed with ROP to those without it.
- The findings revealed that 95.4% of eyes with ROP showed dilation of the SOV, whereas only 15.6% of eyes without ROP exhibited this dilation, indicating a potential link between ROP and changes in the SOV.
Dexamethasone intravitreal implant (Ozurdex®) for pediatric uveitis.
Graefes Arch Clin Exp Ophthalmol
October 2015
Purpose: The purpose of this study was to investigate the safety and effectiveness of an intravitreally injected dexamethasone-containing implant (Ozurdex(®)) in the treatment of uveitis in children.
Methods: The study group included ten patients (14 eyes) aged 6.5-15 years (mean age 12 years) with intermediate or posterior uveitis who were treated with the Ozurdex implant at two tertiary medical centers between 2009 and 2014, following an insufficient response to standard uveitis therapy.
Anti-TNF-α agents for refractory cystoid macular edema associated with noninfectious uveitis.
Graefes Arch Clin Exp Ophthalmol
April 2014
Background: The use of anti-tumor necrosis factor (TNF)-α agents for uveitis has been increasing since the first efficacy studies in 2004. However, information on their specific role in cystic macular edema remains sparse. The aim of this study was to evaluate the efficacy of anti-TNF-α agents for the treatment of uveitis-related refractory cystoid macular edema.
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- The study aimed to see if the time it takes to normalize increased intracranial pressure (ICP) due to intraventricular hemorrhage (IVH) affects treatment for retinopathy of prematurity (ROP) in premature infants.
- Researchers reviewed medical records of premature infants (≤ 35 weeks gestation or ≤ 1500g birth weight) who had both ROP and IVH, comparing those treated for only ICP versus those treated for both conditions.
- Results showed that infants treated for both ROP and ICP took longer to normalize ICP (100 days) compared to those treated for ICP alone (45 days), suggesting that quicker management of ICP might lessen the need for ROP treatment.
Article Synopsis
- The study examines the effectiveness of intravitreal bevacizumab as either a main or additional treatment for severe retinopathy of prematurity in infants.
- Nine infants with severe cases were analyzed; they had varying levels of gestational age and birth weight, and required treatment due to progression despite laser therapies.
- Results showed that bevacizumab successfully reduced active blood vessel growth in all treated eyes, with favorable anatomical outcomes and no significant complications reported.
Article Synopsis
- The study aimed to assess how effective a sub-Tenon's block with ropivacaine is in reducing post-operative pain after strabismus surgery, a procedure that can cause significant discomfort.
- Conducted on 79 patients aged 1 to 65, half received the anesthetic at the end of surgery, and pain levels were measured using a visual analog scale at various times after the procedure.
- Results showed that patients who received the ropivacaine block experienced significantly less pain 12-16 hours post-surgery, required fewer additional painkillers, and reported higher satisfaction compared to those who did not receive the block.
Article Synopsis
- The study aimed to identify when the oculocephalic reflex is suppressed in infants and how it relates to clinical factors like age and weight.
- Conducted on 325 healthy babies, the reflex was tested by moving their heads and observing eye movements, determining that 75% had the reflex suppressed by 11.5 weeks.
- Results indicated that postpartum age was the most significant factor influencing the suppression, and the reflex’s disappearance is a normal part of visual system maturation.*
Article Synopsis
- * In a review of 28 patients (average age 13.4), half had previously undergone surgery, with an overall success rate of 60.7%, which showed no significant difference based on the type of strabismus (esotropia vs. exotropia) or prior treatment.
- * The findings suggest that the effectiveness of combined surgery is consistent regardless of the specific type of horizontal deviation or previous surgical history.
Purpose: To evaluate the efficacy of topical lomefloxacin 0.3% versus chloramphenicol 0.2% with polymyxin B 2500 U/ml in the treatment of patients after strabismus surgery.
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