Serum and peritoneal fluid concentrations of soluble human leukocyte antigen, tumor necrosis factor alpha and interleukin 10 in patients with selected ovarian pathologies.

Background: Although immune system plays a key role in the pathogenesis of both endometriosis and ovarian cancer, its function is different. Therefore, we hypothesized, that selected immune parameters can serve as diagnostic markers of these two conditions. The aim of this study was to compare serum and peritoneal fluid concentrations of sHLA-G, IL-10 and TNF-alpha in women with selected ovarian pathologies: benign serous cysts, endometrioma and malignant tumors.

Ocular manifestations in a newborn from a pregnancy complicated by an antiphospholipid syndrome--a case report.

The paper presents a case of ophthalmologic manifestations, episcleritis and retinal branch vein thrombosis, in a neonate born to a mother with antiphospholipid syndrome (APS) in the course of systemic lupus erythematosus. Female neonate (birth weight 1150 g, Apgar scores 6, 7 and 7) was born with respiratory distress syndrome, moderate anemia and grades I and II intraventricular hemorrhage. Ophthalmic examination revealed an enormous pre-retinal hemorrhage with accompanying thrombotic changes typical of retinal vein in the fundus of the left eye.

Changes in the concentration of sHLA-I and selected cytokines in pregnancy complicated by antiphospholipid syndrome.

Objectives: To compare the serum concentrations of the selected cytokines from subsequent trimesters of antiphospholipid syndrome complicated pregnancies.

Material And Methods: This study included 43 pregnant women (23 patients diagnosed with antiphospholipid syndrome and 20 controls). IL-2R, IL-4, IL-10, INF-gamma, TNF-alpha, and class I sHLA concentrations were analyzed by ELISA in the 1st, 2nd and 3rd trimester

Results: INF-gamma levels were below the method detection threshold and therefore were not included in the final analysis.

Personality traits assessed by the NEO Five-Factor Inventory (NEO-FFI) as part of the perinatal depression screening program.

Background: As pre- and postnatal depression is a multifactorial disorder, the screening programmes which are currently in use in obstetric clinics remain problematic due to their inadequate standardization and limited efficacy. The evaluation of core risk factors for perinatal depression in the screening process, in addition to routine questionnaire-based tools such as the Edinburgh Postnatal Depression Scale (EPDS), might improve the diagnosis and early treatment of women affected by depression. This study was undertaken to analyze the relationship between personality traits and the risk of perinatal depression in pregnant and postpartum women.

[Estimation of diagnostic value of the middle cerebral artery peak systolic velocity in prediction of fetal anemia in pregnancies complicated by alloimmunisation].

Unlabelled: The use of the middle cerebral artery peak systolic velocity (PSV) for the noninvasive diagnosis of fetal anemia in pregnancies complicated by alloimmunisation has the potential to reduce the number of invasive procedures.

Objectives: The study was undertaken to determine the detection of fetal anemia by fetal middle cerebral artery peak systolic velocity (MCA PSV).

Material And Methods: 31 fetuses with red cell alloimmunisation were evaluated with Doppler ultrasongraphy.

Successful outcome of pregnancy complicated by Werner's syndrome.

Werner's syndrome is an extremely rare genetic disorder of the autosomal recessive type, characterized by features suggesting premature aging in young adulthood. Because of the concomitant hypogonadism, pregnancy among patients with Werner's syndrome occurs extremely rarely. We present a case of a successful outcome of pregnancy complicated by Werner's syndrome in a 34-year-old primigravida.

[Birth status and twin birth weight discordance].

Objectives: The aim of the research was to estimate the influence of birth weight discordance on birth status of twins.

Material And Methods: Material of the research consisted of 560 foetuses derived from successful twin pregnancies. In the analysis the following factors were taken into consideration: birth status, gasometry, and birth weight discordance.

[Personality profiles of pregnant and postpartum women with symptoms of perinatal depression: the differences of self image in the sphere of psychological needs].

Objectives: The aim of the following study was to assess personality profiles of pregnant and postpartum women with symptoms of perinatal depression and to estimate the differences in their real and ideal self image in the sphere of psychological needs.

Material And Methods: 50 pregnant (between 32-40 weeks of gestation) and 26 postpartum women (2-5 days after the delivery) were recruited for the study. Edinburgh Postnatal Depression Scale (EPDS) was used as a screening test for symptoms of pre- and postnatal depression.

[Cohabitation as a strong predicting factor of perinatal depression].

Objectives: The aim of this study was to assess if the marital status, especially cohabitation, of pregnant and postpartum women, has any influence on the incidence of perinatal depression symptoms.

Material And Methods: 117 pregnant women (at 32-40 weeks of gestation) and 105 postpartum patients (2-5 days after the delivery) were included in the study. The Edinburgh Postnatal Depression Scale (EPDS) was used as a screening test for symptoms of pre- and postnatal depression.

[Ways of coping in stressful situations and anxiety-state or anxiety-trait among women with symptoms of perinatal depression].

Objectives: The aim of the following study was to establish whether there is any connection between an elevation of anxiety experienced by women during pregnancy or postpartum and their styles of coping with stressful situations, as well as to assess if those factors influence higher risk of incidence of perinatal depressive symptoms.

Material And Methods: A total of 229 patients admitted to the Department of Foeto-Maternal Medicine, Pomeranian Medical University, Szczecin in 2006-2007, were recruited for the study. By means of the Edinburgh Postnatal Depression Scale (EPDS), a study group of 76 pregnant and postpartum women with high risk of perinatal depression was assigned, as well as a control group of 153 patients without such risk.

[HLA-G alleles and risk of early pregnancy loss].

Introduction: To investigate whether HLA-G gene polymorphism is associated with adverse pregnancy outcome, we screened exons 2, 3, 4 of HLA-G gene in 59 women with reproductive failure and 36 fertile women. The HLA-G 10108 allele was more common in the group of examined women than in women from the control group (OR = 5,9; p = 0,09), but this difference was not statistically significant.

Results: We conclude that the HLA-G 10108 allele might influence pregnancy outcome in the Polish population, but further studies are needed in this regard.

[Intrapartum amnioinfusion in patients with meconium-stained amniotic fluid].

Objectives: The aim of the study was to evaluate the effect of intrapartum amnioinfusion in the presence of meconium stained amniotic fluid.

Material And Methods: 93 women with meconium-stained amniotic fluid were assigned to receive amnioinfusion or no amnioinfusion (128 women). The trials were evaluated for fetal distress syndrome, route of delivery, fetal acidemia, Apgar score at 1 and 5 min.

The analysis of the correlation between extracellular fetal DNA concentration in maternal circulation and severity of preeclampsia.

Introduction: Increased fetal DNA in maternal plasma has been reported in pregnancies complicated by preeclampsia. Fetal DNA may by liberated from fetal or placental cells during apoptosis. The aim of the study is the estimation of the correlation between clinical and biochemical characteristics of preeclampsia and the concentration of fetal DNA in maternal circulation.

Antigens HLA-G, sHLA- G and sHLA- class I in reproductive failure.

It can be supposed that relation between HLA-G polymorphism and sHLA-G protein expression are associated with successful embryo implantation and pregnancy maintenance. The aim of the study was the estimation specific differences in expression of sHLA-G and sHLA- class I antigens in women with reproductive failure in comparison with fertile women. The study sample enrolled 80 women, divided into 2 groups.

[Association between HLA-DQA1, HLA-DQB1 alleles and risk of early pregnancy loss].

Aim: The aim of the study is to identify HLA-DQA1, HLA-DQB1 allele and to assess the risk of early pregnancy loss of women, couples with reproductive failure in the first trimester of pregnancy in comparison with fertile women, couples. The study group (B) enrolled 61 couples with reproductive failure and the control group (C) enrolled 20 fertile couples with at least 2 children.

Method: HLA-DQA1 gene typing was performed using PCR-sequence-specific primer (SSP) on the high resolution level according to established procedure of labeling and using the detection kit (FASTYPE DQASSP Typing, FASTYPE DQA "High Resolution" Typing Sheet) purchased from Bio-Synthesis (USA).

[Anomalies of the tongue in the fetus and neonate].

This work reviews the literature on the development of the tongue and its function during fetal life. Research on fetal behavior in general and functioning of structures of the skull, face and neck during fetal life in particular was very difficult, not to say impossible, until the present era of ultrasonography with flow (color Doppler and power Doppler), as well as 3D and 4D imaging. The results of measurements of the tongue, its perimeter, length, and area in normal fetuses and in fetuses with chromosomal aberrations are discussed.

[The prediction of the condition of newborns on the basis of antepartum CTG monitoring and antepartum doppler flow velocity in umbilical arteries in women delivered by caesarean section].

Unlabelled: The aim of the study was the estimation of the condition of newborns delivered by caesarean section depending on antepartum umbilical Doppler flow velocity and CTG monitoring.

Material And Methods: In 213 pregnant women delivered by caesarean section (from preventive and urgent indications before beginning the labor) fetal monitoring included antepartum CTG and Doppler flow velocity up to 7 days before delivery. The CTG recordings before labour were interpreted using a Fischer's method.

[Concentration of procalcitonin in maternal blood, amniotic fluid and in umbilical cord blood as an indicator of neonatal infection].

Unlabelled: THE AIM of this study was to evaluate the usefulness of determining the concentration of procalcitonin (PCT) in the blood of pregnant women, in amniotic fluid and in umbilical blood as a predictor of intrauterine or infant infection.

Material And Methods: the study was conducted on the following material: pregnant women s blood, amniotic fluid and umbilical blood taken during delivery from 60 women and 60 infants. In this group there were 30 vaginal deliveries and 30 deliveries by caesarean section.

[Concentration of the soluble molecule ICAM-1 (sICAM-1) in the amniotic fluid as the marker of the intrauterine infection at pregnant women and at newborns].

Unlabelled: THE AIM of this study was to evaluate the usefulness of determining concentrations of sICAM-1 in amniotic fluid as an indicator of intrauterine infection in pregnant women and infants.

Material And Methods: the study was conducted on a group of 60 pregnant women by taking samples of amniotic fluid during delivery. Thirty of the women in the group had normal delivery and 30 had Caesarean section.

Maternal adipose tissue, maternal and cord blood essential fatty acids and their long-chain polyunsaturated derivatives composition after elective caesarean section.

Background: The essential fatty acids and their long-chain polyunsaturated derivatives (LC PUFAs) are important for the growth and maturation of the fetal organism.

Objective: The aim of a study was to assess the profile of the essential fatty acids and their LC PUFAs in the blood and adipose tissue of pregnant women and in the cord blood after elective caesarean section.

Design: The study group comprised 36 women and 38 their full-term babies born after elective caesarean section.

[Monoamnotic twin pregnancy. Multicenter study].

Objective: The purpose of this study was to evaluate of perinatal mortality and morbidity of monoamniotic twins.

Study Design: This was a multicenter retrospective analysis of 26 monoamniotic twin gestations identified between 1985 and 2004 in a 3 perinatal departments. Of these 26 pregnancies, 11 women were admitted electively for inpatient fetal monitoring.

[Comparison of fetal ECG recordings using STAN S21 analyser and external ECG of newborns, in relation to enzymatic ischaemic markers and acid-base parameters in umbilical blood].

Design: Neonatal hypoxia is often responsible for myocardial ischaemia. To evaluate cardiac involvement in neonates, fetal and neonatal ECG recordings have been performed and parameters indicating heart dysfunction have been analysed.

Objectives: Our interest has been focused on analysis of fetal electrocardiogram recordings using STAN S21 analyser during labour, compared to newborns ECG recordings in the first 12 hours of life, in relation to enzymatic ischaemic markers and acid-base parameters in umbilical blood.

[Caesarean section in preterm labour].

The aim of this study was to estimate complications of pregnancy, indications to caesarean section, complications after caesarean operation and perinatal mortality of newborns who were delivered before the 37th week of gestation by caesarean section. The retrospective analysis of the total of 2693 deliveries (years 1991-2000) by caesarean section in the Department of Pregnancy and Labour Pathology in Pomeranian Academy of Medicine has been carried out. 590 women whose delivered before the 37th week of pregnancy have been chosen for subsequent examination.