The "limbic network," comprising orbitofrontal and anterior temporal cortex, is part of an extended default network: Evidence from multi-echo fMRI.

Resting-state functional magnetic resonance imaging (fMRI) investigations have provided a view of the default network (DN) as composed of a specific set of frontal, parietal, and temporal cortical regions. This spatial topography is typically defined with reference to an influential network parcellation scheme that designated the DN as one of seven large-scale networks (Yeo et al., 2011).

What is autonoetic consciousness? Examining what underlies subjective experience in memory and future thinking.

Autonoetic consciousness is the awareness that an event we remember is one that we ourselves experienced. It is a defining feature of our subjective experience of remembering and imagining future events. Given its subjective nature, there is ongoing debate about how to measure it.

Widespread Autonomic Physiological Coupling Across the Brain-Body Axis.

The brain is closely attuned to visceral signals from the body's internal environment, as evidenced by the numerous associations between neural, hemodynamic, and peripheral physiological signals. We show that these brain-body co-fluctuations can be captured by a single spatiotemporal pattern. Across several independent samples, as well as single-echo and multi-echo fMRI data acquisition sequences, we identify widespread co-fluctuations in the low-frequency range (0.

Lifespan differences in hippocampal subregion connectivity patterns during movie watching.

Age-related episodic memory decline is attributed to functional alternations in the hippocampus. Less clear is how aging affects the functional connections of the hippocampus to the rest of the brain during episodic memory processing. We examined fMRI data from the CamCAN dataset, in which a large cohort of participants watched a movie (N = 643; 18-88 years), a proxy for naturalistic episodic memory encoding.

Peering into the future: Eye movements predict neural repetition effects during episodic simulation.

Imagining future scenarios involves recombining different elements of past experiences into a coherent event, a process broadly supported by the brain's default network. Prior work suggests that distinct brain regions may contribute to the inclusion of different simulation features. Here we examine how activity in these brain regions relates to the vividness of future simulations.

Structure-Function Interactions in the Hippocampus and Prefrontal Cortex Are Associated with Episodic Memory in Healthy Aging.

Aging comes with declines in episodic memory. Memory decline is accompanied by structural and functional alterations within key brain regions, including the hippocampus and lateral prefrontal cortex, as well as their affiliated default and frontoparietal control networks. Most studies have examined how structural or functional differences relate to memory independently.

Creativity at rest: Exploring functional network connectivity of creative experts.

The neuroscience of creativity seeks to disentangle the complex brain processes that underpin the generation of novel ideas. Neuroimaging studies of functional connectivity, particularly functional magnetic resonance imaging (fMRI), have revealed individual differences in brain network organization associated with creative ability; however, much of the extant research is limited to laboratory-based divergent thinking measures. To overcome these limitations, we compare functional brain connectivity in a cohort of creative experts ( = 27) and controls ( = 26) and examine links with creative behavior.

Differences in the content and coherence of autobiographical memories between younger and older adults: Insights from text analysis.

Several studies have shown that older adults generate autobiographical memories with fewer specific details than younger adults, a pattern typically attributed to age-relate declines in episodic memory. A relatively unexplored question is how aging affects the content used to represent and recall these memories. We recently proposed that older adults may predominately represent and recall autobiographical memories at the gist level.

Taking stock of the past: A psychometric evaluation of the Autobiographical Interview.

Autobiographical memory (AM) involves a rich phenomenological re-experiencing of a spatio-temporal event from the past, which is challenging to objectively quantify. The Autobiographical Interview (AI; Levine et al. Psychology and Aging, 17(4), 677-689, 2002) is a manualized performance-based assessment designed to quantify episodic (internal) and semantic (external) features of recalled and verbally conveyed prior experiences.

Neurocognitive aging data release with behavioral, structural and multi-echo functional MRI measures.

Central to understanding human behavior is a comprehensive mapping of brain-behavior relations within the context of lifespan development. Reproducible discoveries depend upon well-powered samples of reliable data. We provide to the scientific community two, 10-minute, multi-echo functional MRI (ME-fMRI) runs, and structural MRI (T1-MPRAGE), from 181 healthy younger (ages 18-34 y) and 120 older adults (ages 60-89 y).

Temporal pole volume is associated with episodic autobiographical memory in healthy older adults.

Recollection of personal past events differs across the lifespan. Older individuals recall fewer episodic details and convey more semantic information than young. Here we examine how gray matter volumes in temporal lobe regions integral to episodic and semantic memory (hippocampus and temporal poles, respectively) are related to age differences in autobiographical recollection.

Age differences in the functional architecture of the human brain.

The intrinsic functional organization of the brain changes into older adulthood. Age differences are observed at multiple spatial scales, from global reductions in modularity and segregation of distributed brain systems, to network-specific patterns of dedifferentiation. Whether dedifferentiation reflects an inevitable, global shift in brain function with age, circumscribed, experience-dependent changes, or both, is uncertain.

White matter lesion load is associated with lower within- and greater between- network connectivity across older age.

White matter hyperintensities (WMH) are among the most prominent structural changes observed in older adulthood. These changes coincide with functional changes to the intrinsic network organization of the aging brain. Yet little is known about how WMH are associated with changes to the whole-brain functional connectome in normal aging.

Age differences in intuitive moral decision-making: Associations with inter-network neural connectivity.

Positions of power involving moral decision-making are often held by older adults (OAs). However, little is known about age differences in moral decision-making and the intrinsic organization of the aging brain. In this study, younger adults (YAs; = 117, = 22.

Troubled past: A critical psychometric assessment of the self-report Survey of Autobiographical Memory (SAM).

The Survey of Autobiographical Memory (SAM) was designed as an easy-to-administer measure of self-perceived autobiographical memory (AM) recollection capacity. We provide a comprehensive psychometric evaluation of the SAM in younger and older adults. First, we evaluated the reliability of the SAM as a measure of self-perceived recollective capacity.

Inter-regional BOLD signal variability is an organizational feature of functional brain networks.

Neuronal variability patterns promote the formation and organization of neural circuits. Macroscale similarities in regional variability patterns may therefore be linked to the strength and topography of inter-regional functional connections. To assess this relationship, we used multi-echo resting-state fMRI and investigated macroscale connectivity-variability associations in 154 adult humans (86 women; mean age = 22yrs).

Mind the gap: Congruence between present and future motivational states shapes prospective decisions.

Poor estimation of one's future actions has been associated with the influence of reward over executive control processes during prospection. However, the neural mechanisms underlying this reward-control trade-off remain poorly understood. In the present study, we take advantage of projection bias, underestimating how motivations will change in the future, to examine brain and behavior changes during prospection about future decisions.

Semanticized autobiographical memory and the default - executive coupling hypothesis of aging.

As we age, the architecture of cognition undergoes a fundamental transition. Fluid intellectual abilities decline while crystalized abilities remain stable or increase. This shift has a profound impact across myriad cognitive and functional domains, yet the neural mechanisms remain under-specified.

Financial Exploitation Is Associated With Structural and Functional Brain Differences in Healthy Older Adults.

Background: Age-related brain changes leading to altered socioemotional functioning may increase vulnerability to financial exploitation. If confirmed, this would suggest a novel mechanism leading to heightened financial exploitation risk in older adults. Development of predictive neural markers could facilitate increased vigilance and prevention.

An Overview of Judgment and Decision Making Research Through the Lens of Fuzzy Trace Theory.

We present the basic tenets of fuzzy trace theory, a comprehensive theory of memory, judgment, and decision making that is grounded in research on how information is stored as knowledge, mentally represented, retrieved from storage, and processed. In doing so, we highlight how it is distinguished from traditional models of decision making in that gist reasoning plays a central role. The theory also distinguishes advanced intuition from primitive impulsivity.

Genetic mapping and exome sequencing identify variants associated with five novel diseases.

The Clinic for Special Children (CSC) has integrated biochemical and molecular methods into a rural pediatric practice serving Old Order Amish and Mennonite (Plain) children. Among the Plain people, we have used single nucleotide polymorphism (SNP) microarrays to genetically map recessive disorders to large autozygous haplotype blocks (mean = 4.4 Mb) that contain many genes (mean = 79).