Combined effects of carbon ion radiation and PARP inhibitor on non-small cell lung carcinoma cells: Insights into DNA repair pathways and cell death mechanisms.

The utilization of high linear energy transfer (LET) carbon ion (C-ion) in radiotherapy has witnessed a notable rise in managing highly metastatic, recurrent, and chemo/radio-resistant human cancers. Non-small cell lung cancer (NSCLC) presents a formidable challenge due to its chemo-resistance and aggressive nature, resulting in poor prognosis and survival rates. In a previous study, we demonstrated that the combination of C-ion with the poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) olaparib significantly mitigated metastasis in A549 cells.

Quantification of the effects of conservation practices on surface runoff and soil erosion in croplands and their trade-off: A meta-analysis.

Soil erosion coupled with high runoff poses a significant threat to the topsoil fertility, declining its productivity and raising major environmental and socio-economic issues such as land degradation, desertification, food scarcity, and hunger globally. Several conservation methods have been widely adopted in order to reduce runoff and protect the soil from erosion. The effectiveness of such conservation practices are controlled by many factors (i.