Publications by authors named "Roni Kohen"
Article Synopsis
- Major complications of diabetes, such as inflammation, oxidative stress, and delayed wound healing, increase the need for early detection of at-risk tissue to improve management and reduce associated healthcare costs.
- The study compared the wound healing processes in diabetic rats and non-diabetic controls using imaging techniques, revealing that diabetic wounds healed more slowly and showed differing levels of blood components like oxyhaemoglobin and deoxyhaemoglobin.
- Increased levels of inducible nitric oxide synthase (iNOS) in diabetic wounds were linked to heightened inflammation, which correlated with impaired wound healing, highlighting the potential of Spatial Frequency Domain Imaging (SFDI) as a non-invasive tool for assessing wound healing in diabetes.
Nitroxide radicals protect cultured rat embryos and yolk sacs from diabetic-induced damage.
Birth Defects Res A Clin Mol Teratol
August 2007
Background: Diabetic teratogenicity relates, partly, to embryonic oxidative stress and the extent of the embryonic damage can apparently be reduced by antioxidants. We investigated the effects of superoxide dismutase-mimics nitroxides, 2,2,6,6-tetramethyl piperidine-N-oxyl (TPL) as an effective antioxidant, on diabetes-induced embryopathy.
Methods: Embryos (10.
The literature evidencing the role of iron in promoting a range of neoplasms in humans and animals prompted us to search for a possible association between chemically induced hemosiderosis and hemangiosarcomas in the liver of mice in selected studies conducted by the National Toxicology Program (NTP). Its historical control database was examined for studies in which treatment-related liver hemangiosarcoma was noted; 130 consecutive NTP studies in B6C3F1 mice from Technical Report (TR)-340 to TR-493 were evaluated. Three compounds (2-butoxyethanol, p-nitroaniline, and para-chloroaniline) were associated with a relatively high incidence of Kupffer cell pigmentation consisting of hemosiderin in both sexes; only the male mice developed a relatively low incidence of treatment-related hemangiosarcoma.
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