Publications by authors named "Rongzhou He"
Background: Developing a molecular signature associated with CD4 + T cell infiltration is essential for identifying biomarkers in abdominal aortic aneurysms (AAA). Establishing such a signature is vital for improving diagnostic accuracy and therapeutic strategies for AAA. This study focuses on CD4 + T cells, which are pivotal in the immune microenvironment of AAA, to pinpoint key targets.
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- - Arteriosclerosis obliterans (ASO) is a serious vascular condition linked to large vessel atherosclerosis, where uncontrolled proliferation of vascular smooth muscle cells (VSMCs) is a key problem, but the exact cause is not well understood.
- - Recent research indicates that long non-coding RNAs (lncRNAs) play a crucial role in ASO progression by promoting VSMC growth through a mechanism dependent on the endogenous competitive RNA (ceRNA) hypothesis, though a full regulatory map is still needed.
- - The study identified three specific lncRNAs that significantly influenced VSMC proliferation and immune interactions, with one lncRNA being notably down-regulated in ASO arteries, suggesting its importance for potential
Integrative analysis prioritizes the relevant genes and risk factors for chronic venous disease.
J Vasc Surg Venous Lymphat Disord
May 2022
Objective: Chronic venous disease (CVD) refers to a range of symptoms resulting from long-term morphological and functional abnormalities of the venous system. However, the mechanism of CVD development remains largely unknown. Here, we aim to provide more information on CVD pathogenesis, prevention strategies, and therapy development through the integrative analysis of large-scale genetic data.
View Article and Find Full Text PDFBackground: The optimal anticoagulant scheme during catheter-directed thrombolysis (CDT) for deep venous thrombosis (DVT) remains unknown. This study was performed to evaluate the feasibility of anticoagulation therapy using low molecular-weight heparin (LMWH) during CDT for DVT.
Methods: The clinical data of DVT patients who underwent CDT during the past six years was retrospectively collected and reviewed.
Increasing evidence suggests that T‑cell immunoglobulin and mucin domain 3 (TIM‑3) displays anti‑atherosclerotic effects, but its role in vascular smooth muscle cells (VSMCs) has not been reported. The present study aimed to investigate the function of TIM‑3 and its roles in human artery VSMCs (HASMCs). A protein array was used to investigate the TIM‑3 protein expression profile, which indicated that TIM‑3 expression was increased in the serum of patients with lower extremity arteriosclerosis obliterans disease (LEAOD) compared with healthy individuals.
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- The study investigates different endovascular treatments for femoropopliteal arterial diseases, focusing on drug eluting stents (DES), covered stents (CS), drug coated balloons (DCB), bare metal stents (BMS), and angioplasty (PTA) to see which is most effective in preventing restenosis.
- A comprehensive network meta-analysis of 28 trials involving 4728 patients found DES to be the most effective for maintaining primary patency, particularly in short lesions, but showed no significant difference compared to CS, DCB, and BMS overall.
- The analysis concluded that while DES is effective for mid-term patency in short lesions, DCB appears to be the best option for preventing target lesion