Liquid Bridge Cutting Valves for Microfluidic Passive Distribution and Sequential Reaction.

In bioanalysis, precisely isolating liquid reactions in distinct systems or at different temporal sequences is vital for ensuring accurate results devoid of crosstalk. However, passive liquid isolation is unattainable through existing microfluidic valves. Here, liquid bridge cutting valves (LBCVs) are introduced to automatically segregate liquids by establishing airlocks, offering an innovative microfluidic structure for liquid distribution.

Implantable wireless suture sensor for in situ tendon and ligament strain monitoring.

Tendon and ligament ruptures are prevalent, and severe sports injuries require surgical repair. In clinical practice, monitoring of tissue strain is critical to alert severe postoperative complications such as graft reinjury and loosening. Here, we present a sensor system that integrates a strain sensor and communication coil onto surgical silk sutures, enabling in situ monitoring and wireless readout of tissue strains via surgical implantation.

Printable Strain Sensors with Viscosity-Adjustable Ionic Liquids for Motion Monitoring.

Flexible strain sensors with ionic liquids have broad application prospects in various fields such as human-machine interaction, motion monitoring, and soft robots due to their conformability. The manufacture of strain sensors based on ionic liquids mainly relies on traditional molding methods and embedded 3D printing methods. However, these methods are complicated and involve lots of manual operations because of the strong fluidity of ionic liquids.

Nano Foldaway Skin-like E-interface for Detecting Human Bioelectrical Signals.

Flexible electrodes applied to different positions of the human body to detect bioelectrical signals need to be conductive with respect to both the skin and the external circuit. However, electrodes fabricated with micromachining can only be made conductive on one side, which requires inserting connection wires, thus affecting skin adhesion and leading to a more fragile circuit on the soft substrate. This paper proposes an e-interface designed with an innovative folding transfer process, which can fold nanometer thick electrodes in a macroscopic way.

Introducing Temperature-Controlled Phase Transition Elastin-like Polypeptides to Transient Electronics: Realization of Proactive Biotriggered Electronics with Local Transience.

Transient electronics have dramatically changed inner-body therapy in health care. They stand out because of their harmless dissolution in the human body with no lingering electronic trash. However, high-precision biomedical implants require programmable and serial remedy operations, and controlling the whole-device destruction is not proactive and precise.

Low melting point metal-based flexible 3D biomedical microelectrode array by phase transition method.

In this study, we present a dimension-controllable 3D biomedical microelectrode based on low melting point metals (Bi/In/Sn/Zn alloy) applied using the phase transition method. We have established a process, in which the liquid metal is pumped through a syringe needle of the dispensing system to form a needle shape after cooling at room temperature. PDMS (polydimethylsiloxane) was chosen as the substrate of the electrode as it is amenable to micro-molding and has excellent flexibility.

An interferometric imaging biosensor using weighted spectrum analysis to confirm DNA monolayer films with attogram sensitivity.

Interferometric imaging biosensors are powerful and convenient tools for confirming the existence of DNA monolayer films on silicon microarray platforms. However, their accuracy and sensitivity need further improvement because DNA molecules contribute to an inconspicuous interferometric signal both in thickness and size. Such weaknesses result in poor performance of these biosensors for low DNA content analyses and point mutation tests.