Enhancement of HPV therapeutic peptide-based vaccine efficacy through combination therapies and improved delivery strategies: A review.

Human papillomavirus (HPV) has been linked to the development of various cancers, including head and neck, cervical, vaginal, penile, and anal cancers. The development of therapeutic vaccines against HPV-positive tumors is crucial for protecting individuals already infected with HPV, preventing tumor progression, and effectively treating the disease. The HPV therapeutic peptide-based vaccines demonstrate specificity and safety advantages by targeting specific epitopes while minimizing the risk of allergic or autoimmune reactions.

Increased cysteinyl-tRNA synthetase drives neuroinflammation in Alzheimer's disease.

Background: Microglia-mediated neuroinflammation in Alzheimer's disease (AD) is not only a response to pathophysiological events, but also plays a causative role in neurodegeneration. Cytoplasmic cysteinyl-tRNA synthetase (CARS) is considered to be a stimulant for immune responses to diseases; however, it remains unknown whether CARS is involved in the pathogenesis of AD.

Methods: Postmortem human temporal cortical tissues at different Braak stages and AD patient-derived serum samples were used to investigate the changes of CARS levels in AD by immunocytochemical staining, real-time PCR, western blotting and ELISA.

Second harmonic generation in an anisotropic lithium niobate metasurface governed by quasi-BICs.

Resonant metasurfaces can greatly trap the light fields, so that they are widely used to enhance light-matter interactions at the nanoscale, such as promoting nonlinear effects of materials. Lithium niobate (LN) is an excellent nonlinear optical material and is often employed to generate harmonic signals. In this Letter, we numerically study the second harmonic generation (SHG) characteristics of the LN metasurface based on the quasi-bound states in the continuum (QBIC).

Morphological and phylogenetic analyses reveal two new species and a new record of (Amphisphaeriales, Apiosporaceae) in China.

The genus includes endophytes, pathogens and saprobes, with a wide host range and geographic distribution. In this paper, six strains isolated from diseased and healthy tissues of bamboo leaves from Hainan and Shandong provinces in China were classified using a multi-locus phylogeny based on a combined dataset of ITS, LSU, and , in conjunction with morphological characters, host association and ecological distribution. Two new species, and , and a new record of in China, are described based on their distinct phylogenetic relationships and morphological analyses.

Environmental Friendly Modification of the Superhydrophobic Surface for Iron-Based Amorphous Alloy Films and Their Magnetic Surface Effect.

It is challenging to convert the superhydrophobic surfaces of iron-based amorphous films into hydrophilic surfaces through surface treatment. In this study, a novel, environmentally friendly method is used to change the superhydrophobic surfaces of FeSiB amorphous alloy films, which include their rougher and smoother surfaces. The boron element in the films reacted with the flavonoids and anthocyanins in the solution to create organic conversion membranes and organic boronizing naphthoquinone derivatives on the surfaces of the films when they were dipped in tea polyphenol aqueous solution at 80 °C for 60 min.

Positive clinical outcomes following therapy with programmed cell death protein 1/programmed cell death ligand 1 inhibitors in neuroendocrine carcinoma of the cervix.

Neuroendocrine carcinoma of the cervix (NECC) is a highly aggressive and rare gynecological malignancy with a poor prognosis. Despite aggressive local and systemic treatments, there are high rates of locoregional recurrence and distant metastases. Therefore, more potent treatments are required to manage NECC.

The diagnostic value of Hsp90α in monitoring treatment responses in lung cancer.

Background: Heat shock protein 90α (Hsp90α) is considered a tumor biomarker in many human malignancies. This study investigated the diagnostic value of Hsp90α combined with other traditional lung cancer biomarkers (CEA, CYFRA21-1, and NSE) and its role in monitoring the treatment response of lung cancer patients.

Methods: A total of 205 patients with lung cancer and 186 patients with lung benign disease who were admitted to our hospital were enrolled from 2018 to 2020.

Morphological and Phylogenetic Analyses Reveal Four New Species of () in China.

During our ongoing survey of dematiaceous hyphomycetes associated with dead branches in tropical forests, eight isolates were collected from Hainan, China. Morphology from the cultures and phylogeny based on partial small subunit (SSU), entire internal transcribed spacer regions with intervening 5.8S (ITS), partial large subunit (LSU) of rRNA gene, partial beta-tubulin (tub2), and partial RNA polymerase II second largest subunit (rpb2) genes were employed to identify these isolates.

Morphological and Phylogenetic Analyses Reveal Four New Species of (, ) from China.

The fungal genus (, ) has been reported all around the world and isolated from multiple plant hosts. Based on multilocus phylogenies from a combined dataset of internal transcribed spacer (ITS) region, the ribosomal RNA gene cluster, and partial regions of translation elongation factor 1 alpha () and partial beta-tubulin (), in conjunction with morphological characteristics, we describe and illustrate herein four new species, including sp. Nov.

Associations between comorbidities and annual incidence plus frequency of asthma exacerbation hospitalisation during the past year: data from CARN study.

Purpose: While asthma comorbidities are associated with higher health care utilisation, lower quality of life and poorer asthma control, the impact of asthma comorbidities on hospitalisation for asthma exacerbation (H-AX) remains less recognised. We aim to analyse the impact of asthma comorbidities on H-AX.

Methods: Based on a national survey on asthma control and disease perception (CARN 2015 study), we analysed the impact of comorbidities on annual incidence and frequency of H-AX in China.

The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review.

Medicinal plants are considered to be a critical source of novel compounds and pharmacophores. The genus Ardisia, consisting of approximately 500 species, is the largest genus in the Myrsinaceae family. Ardisia species are widely distributed throughout tropical and subtropical regions of the world and have been used for the treatment of cancer, hypertension, irregular menstruation, gonorrhea, diarrhea and postnatal syndromes, among others.

Morphological and phylogenetic analyses reveal two new species of Sporocadaceae from Hainan, China.

Species of Sporocadaceae have often been reported as plant pathogens, endophytes or saprophytes and are commonly isolated from a wide range of plant hosts. The isolated fungi were studied through a complete examination, based on multilocus phylogenies from combined datasets of ITS//, in conjunction with morphological characteristics. Nine strains were isolated from , and in China which represented four species, , , , and .

Asthma Management Using the Mobile Asthma Evaluation and Management System in China.

Purpose: As stated in the Global Initiative for Asthma, there are still some asthmatic patients who have not achieved asthma control. Mobile is a useful tool for asthma management. We aimed to compare the advantages of mobile management with traditional management in improving adherence and control of asthma.

Morphological and molecular phylogenetic analyses reveal three species of in Shandong province, China.

has numerous host range and distribution. Its species are important plant pathogens, endophytes and saprobes. can cause regular or irregular depressions and necrotic lesions in the epidermal tissues of plants.

Morphological and phylogenetic analyses reveal a new genus and two new species of Tubakiaceae from China.

Species of Tubakiaceae have often been reported as plant pathogens or endophytes, commonly isolated from a wide range of plant hosts. The isolated fungi were studied through a complete examination, based on multilocus phylogenies from combined datasets of ITS/LSU/ and ITS//, in conjunction with morphological characteristics. Five strains isolated from and in China represented a new genus of Tubakiaceae, and three species, viz.

Bevacizumab biosimilar LY01008 compared with bevacizumab (Avastin) as first-line treatment for Chinese patients with unresectable, metastatic, or recurrent non-squamous non-small-cell lung cancer: A multicenter, randomized, double-blinded, phase III trial.

Background: Previous studies have demonstrated the preclinical pharmacological and toxicological consistency, and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab (Avastin). This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC).

Methods: Stage IIIB-IV NSCLC patients with evaluable lesions, good physical status, and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin (combined treatment) for 4-6 cycles, followed by maintenance monotherapy with LY01008 until disease progression, intolerable toxicity, or death.

Purification, characterization, and in vitro antitumor activity of a novel glucan from the purple sweet potato Ipomoea Batatas (L.) Lam.

A novel glucan PSPP-1 (18.3 kDa) was purified from the foot tuber of purple sweet potato Ipomoea Batatas (L.) Lam.

TLR2 favors OVA-induced allergic airway inflammation in mice through JNK signaling pathway with activation of autophagy.

Aims: Numerous studies indicate that toll-like receptor 2 (TLR2) led to divergent effects in asthma. The occurrence of autophagy in asthma pathogenesis is still incompletely understood. Here, we aimed to investigate the role of TLR2 and the underlying mechanisms in allergic airway inflammation and autophagy activation.