Multifunctional modified polylactic acid nanofibrous scaffold incorporating sodium alginate microspheres decorated with strontium and black phosphorus for bone tissue engineering.

Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies. However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the biomineralization. Furthermore, effective anti-inflammatory activity for the scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.

Biomimetic mineralization of nanocrystalline hydroxyapatites on aminated modified polylactic acid microspheres to develop a novel drug delivery system for alendronate.

EPLA/nHAp composite microsphere, a novel drug delivery system potentially useful for the local delivery of alendronate (AL) to bone tissue was developed via the biomimetic mineralized deposition of nano-hydroxyapatite (nHAp) crystals on the surface of aminated modified polylactic acid (EPLA) microspheres. Scanning electron microscopy (SEM) observation showed that this system consisted of a polymer core with nanofiber network structure and inorganic coating composed of countless rod-like nanocrystalline particles, Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction analysis (XRD) confirmed that these particles were nHAp crystals. An efficient AL-loading can be realized by facile impregnation-adsorption method under suitable conditions due to the high adsorption capacity of EPLA/nHAp composite microspheres.

Fabrication and characterization of poly (ethylenimine) modified poly (l-lactic acid) nanofibrous scaffolds.

Bone tissue engineering aims to construct biological substitutes for repairing bone defects. Nanofibrous (NF) scaffolds are commonly utilized to mimic the extracellular matrix (ECM) environment and promote tissue regeneration in tissue engineering process. Poly (lactic acid) (PLA) has attracted much attention in the field of tissue engineering because of its biocompatibility, biodegradability and so on.