Dysthyroid optic neuropathy treated with tocilizumab.

Summary: Dysthyroid optic neuropathy (DON) is the most serious complication associated with Graves' orbitopathy (GO). The primary treatment approach for DON is high-dose intravenous methylprednisolone infusion and decompression surgery. However, not all patients are suitable candidates for or can tolerate these two treatment options.

A comprehensive epigenetic network can influence the occurrence of thyroid-associated ophthalmopathy by affecting immune and inflammatory response.

The primary objective of this study is to understand the regulatory role of epigenetics in thyroid-associated ophthalmopathy (TAO) using multi-omics sequencing data. We utilized tRFs sequencing data, DNA methylation sequencing data, and lncRNA/circRNA/mRNA sequencing data, as well as several RNA methylation target prediction websites, to analyze the regulatory effect of DNA methylation, non-coding RNA, and RNA methylation on TAO-associated genes. Through differential expression analysis, we identified 1019 differentially expressed genes, 985 differentially methylated genes, and 2601 non-coding RNA.

Short night-time sleep duration is associated with thyroid nodules: A community-based survey from Guangzhou, China.

Background: Sleep plays a critical role in maintaining human health. This study aimed to explore the association between sleep status and thyroid nodules.

Methods: A total of 2414 individuals aged 18 or older with euthyroidism were enrolled in this community-based survey.

Hydrolyzed low-molecular-weight polysaccharide from Enteromorpha prolifera exhibits high anti-inflammatory activity and promotes wound healing.

Increased anti-inflammatory activity is key to accelerating wound healing. In this study, we prepared three types of water-soluble polysaccharides from Enteromorpha prolifera (PEPs) with different molecular weights by hydrochloric acid hydrolysis and evaluated their anti-inflammatory activity and wound-healing effects. The results showed that, under in vitro conditions, the low molecular-weight polysaccharide (LPEP) exhibited high anti-inflammatory activity and suppressed the production of nitric oxide (NO), tumour necrosis factor α (TNF-α), and interleukins (IL-1β, and IL-6) from macrophage RAW 264.

Chitin-hydroxyapatite-collagen composite scaffolds for bone regeneration.

Bone defect is usually difficult to recover quickly, and bone scaffold transplantation is considered to be an effective method. Biomaterials have a wide range of application prospects in bone tissue repair, and the two key problems are the selection of materials and cells. The object of this study was to discuss the structural characteristics of bone scaffold materials and their effects on bone repair in vivo.

Preparation of sustainable non-combustion filler substrate from waterworks sludge/aluminum slag/gypsum/silica/maifan stone for phosphorus immobilization in constructed wetlands.

In this study, an artificial wetland filler matrix capable of effectively fixing phosphorus was prepared using a non-combustion process to save energy. To evaluate the adsorption performance of this filler, adsorption experiments were performed and the phosphorus adsorption mechanism characterization was studied. An alkaline environment was found to be conducive to the increase of adsorption capacity, but excessive alkalinity was not conducive to adsorption.