Harnessing ZIKV NS2A RNA for alleviating acute hepatitis and cytokine release storm by targeting translation machinery.

Background And Aims: Hyperactivated inflammatory responses induced by cytokine release syndrome are the primary causes of tissue damage and even death. The translation process is precisely regulated to control the production of proinflammatory cytokines. However, it is largely unknown whether targeting translation can effectively limit the hyperactivated inflammatory responses during acute hepatitis and graft-versus-host disease.

Climate suitability division of solar greenhouse in Inner Mongolia Autonomous Region, China.

To resolve the issue of scientific planning and rational layout of different vegetable greenhouses in Inner Mongolia Autonomous Region, we selected the days of low temperature in winter, sunshine hours, overcast days, extreme minimum temperature, days of monsoon disaster, days of snow cover in production season of greenhouse as the climate zoning indicators, based on ground-based observation data from 119 meteorological stations (1991 to 2020) and the growing demand of leafy and fruity vegetables in greenhouse, combined with the analysis of key meteorological factors in production season and the study of meteorological disaster indicators such as low temperature and cold damage, wind disaster, snow disaster. We analyzed the indices, classification and division of comprehensive climate suitability zoning of leafy and fruity vegetables at various slopes (35°, 40°) of solar greenhouse by the weighted sum method. The results showed that the climatic suitability zoning grades of leafy and fruity vegetables at 35° and 40° slope of greenhouse was highly consistent, and that the greenhouse climate suitability of leafy vegetables was higher than that of fruity vegetables in the same region.

STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.

γ-interferon-inducible protein-16 (IFI16), a key DNA sensor, triggers downstream STING-dependent type I interferon (IFN-I) production and antiviral immunity. However, it is still unclear how to negatively regulate IFI16 to avoid excessive IFN-I production and autoimmunity. Here, we find that STING directly interacts with IFI16 and facilitates IFI16 degradation via the ubiquitin-proteasome pathway by recruiting the E3 ligase TRIM21.

[Light and temperature indices during the seeding stage of spring maize in Hetao irrigation district, Inner Mongolia, China].

We collected the experimental dataset of a spring-maize in Hetao irrigation district (Bayannaoer, Inner Mongolia) during 2012 and 2013, as well as the crop data observed in related agrometeorological stations to investigate the impacts of light and temperature variation on maize development during the seedling stage to derive adequate light and temperature indices for different suitability. Furthermore, polynomial fitting was applied to interpolate the temperature indices for each day of the whole seedling period to draw the dynamics of the temperature indices and to better characterize its influence on maize development during the seedling stage. The results suggested that the emergence and development rates increased by 11% and 12%, respectively when the average temperature increased 1 °C during the sowing-emergence period and emergence-jointing period, and the biological lowest temperature was 7.