Publications by authors named "Rongru Zhu"
MicroRNAs play essential roles in biological processes by regulating gene expression at the post-transcriptional level. Our previous studies suggested the role of miR-26a in porcine fat accumulation. Here, through gain- and loss-of-function analyses, we first showed that miR-26a increased the proliferation of porcine preadipocytes by promoting cell division and that miR-26a inhibited the preadipocyte differentiation.
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- Alternative polyadenylation (APA) is highlighted as a key regulatory mechanism for gene expression in pig muscles, similar to alternative splicing (AS), contributing to the complexity of the transcriptome and proteome.
- Through long-read isoform sequencing, novel transcripts were discovered at various developmental stages, revealing extensive transcript diversity and identifying significant genes related to muscle growth and development.
- The study uncovers that changes in alternative splicing and polyadenylation site usage are linked to ageing, emphasizing the role of APA and AS in regulating muscle gene expression and enhancing transcriptional variety.
Adipose tissue is conventionally recognized as a metabolic organ responsible for storing energy. However, a proportion of adipose tissue also functions as a thermogenic organ, contributing to the inhibition of weight gain and prevention of metabolic diseases. In recent years, there has been significant progress in the study of thermogenic fats, particularly brown adipose tissue (BAT).
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