Risk distribution of human infections with avian influenza A (H5N1, H5N6, H9N2 and H7N9) viruses in China.

Background: This study aimed to investigate epidemiologic characteristics of major human infection with avian influenza and explore the factors underlying the spatial distributions, particularly H5N6 and H9N2, as H9N2 could directly infect mankind and contribute partial or even whole internal genes to generate novel human-lethal reassortants such as H5N6. They pose potential threats to public health and agriculture.

Methods: This study collected cases of H5N1, H5N6, H9N2, and H7N9 in China, along with data on ecoclimatic, environmental, social and demographic factors at the provincial level.

Integrating Contrastive Learning and Cycle Generative Adversarial Networks for Non-invasive Fetal ECG Extraction.

Fetal electrocardiogram (FECG) contains crucial information about the fetus during pregnancy, making the extraction of FECG signal essential for monitoring fetal health. However, extracting FECG signal from abdominal electrocardiogram (AECG) poses several challenges: (1) FECG signal is often contaminated by noise, and (2) FECG signal is frequently overshadowed by high-amplitude maternal electrocardiogram (MECG). To address these issues and enhance the accuracy of signal extraction, this paper proposes an improved Cycle Generative Adversarial Networks (CycleGAN) with integrated contrastive learning for FECG signal extraction.

Function and molecular mechanism analysis of CaLasSDE460 effector involved in the pathogenesis of "Candidatus Liberibacter asiaticus" in citrus.

Citrus Huanglongbing (HLB), caused by Candidatus Liberibacter asiaticus (CaLas), is the most serious disease worldwide. CaLasSDE460 was previously characterized as a potential virulence factor of CaLas. However, the function and mechanism of CaLasSDE460 involved in CaLas against citrus is still elusive.

Short-term ozone exposure and serum neural damage biomarkers in healthy elderly adults: Evidence from a panel study.

Background: Although converging lines of research have pointed to the adverse neural effects of air pollution, evidence linking ozone (O) and neural damage remains limited.

Objectives: To investigate the subclinical neural effects of short-term ozone (O) exposure in elderly adults.

Methods: A panel of healthy elderly individuals was recruited, and five repeated measurements were conducted from December 2018 to April 2019 in Xinxiang, China.

Acute effects of ambient nitrogen dioxide exposure on serum biomarkers of nervous system damage in healthy older adults.

Ambient nitrogen dioxide (NO)-induced adverse health effects have been studied, but documented evidence on neural systems is limited. This study aimed to determine the acute effect of NO exposure on nervous system damage biomarker levels in healthy older adults. Five rounds of follow-up among 34 healthy retired people were scheduled from December 2018 to April 2019 in Xinxiang, China.

Microglial Activation and Oxidative Stress in PM-Induced Neurodegenerative Disorders.

Fine particulate matter (PM) pollution remains a prominent environmental problem worldwide, posing great threats to human health. The adverse effects of PM on the respiratory and cardiovascular systems have been extensively studied, while its detrimental effects on the central nervous system (CNS), specifically neurodegenerative disorders, are less investigated. Neurodegenerative disorders are characterized by reduced neurogenesis, activated microglia, and neuroinflammation.

Subclinical cardiovascular outcomes of acute exposure to fine particulate matter and its constituents: A glutathione S-transferase polymorphism-based longitudinal study.

To explore the acute subclinical cardiovascular effects of fine particulate matter (PM) and its constituents, a longitudinal study with 61 healthy young volunteers was conducted in Xinxiang, China. Linear mixed-effect models were used to analyze the association of PM and its constituents with cardiovascular outcomes, respectively, including blood pressure (BP), heart rate (HR), serum levels of high-sensitivity C-reactive protein (hs-CRP), 8-hydroxy-2'-deoxyguanosine (8-OHdG), tissue-type plasminogen activator (t-PA), and platelet-monocyte aggregation (PMA). Additionally, the modifying effects of glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1) polymorphisms were examined.

Overexpression of a " Liberibacter Asiaticus" Effector Gene Contributes to Early Colonization in .

Huanglongbing (HLB), caused by " liberibacter asiaticus" (Las), is one of the most devastating diseases in citrus but its pathogenesis remains poorly understood. Here, we reported the role of the LasSDE115 (CLIBASIA_05115) effector, encoded by Las, during pathogen-host interactions. Bioinformatics analyses showed that LasSDE115 was 100% conserved in all reported Las strains but had sequence differences compared with orthologs from other " liberibacter.

Associations of Short-Term Exposure to Fine Particulate Matter with Neural Damage Biomarkers: A Panel Study of Healthy Retired Adults.

Exposure to fine particulate matter (PM) is associated with various adverse health effects, such as respiratory and cardiovascular diseases. This study aimed to evaluate the association of PM with neural damage biomarkers. A total of 34 healthy retirees were recruited from Xinxiang Medical University from December 2018 to April 2019.