A Rab10-ACAP1-Arf6 GTPases cascade modulates M4 muscarinic acetylcholine receptor trafficking and signaling.

Membrane trafficking processes regulate the G protein-coupled receptor activity. The muscarinic acetylcholine receptors (mAChRs) are highly pursued drug targets for neurological diseases, but the cellular machineries that control the trafficking of these receptors remain largely elusive. Here, we revealed the role of the small GTPase Rab10 as a negative regulator for the post-activation trafficking of M4 mAChR and the underlying mechanism.

Functional exercise in combination with auricular plaster therapy is more conducive to rehabilitation of menopausal women patients with anxiety disorder.

Objective: Observe the effect of functional exercise in combination with auricular plaster therapy on menopausal women patients with anxiety disorder.

Method: Select 45 menopausal women patients with anxiety disorder and then adopt random digital table to divide them into a functional exercise group, an auricular plaster therapy group and a combination group. Each group consists of 15 patients.

Conspicuous effect on treatment of mild-to-moderate COPD by combining deep-breathing exercise with oxygen inhalation.

Chronic obstructive pulmonary disease (COPD) can lead to respiratory failure, but current pharmacological treatments focus on symptom relief or slowing disease progression. Here, the effectiveness of an alternative therapy combining deep-breathing exercises and oxygen inhalation therapy was assessed in mild-to-moderate COPD patients. Forty-two male mild-to-moderate COPD patients were randomly divided into a deep-breathing training group, an oxygen inhalation group, and a combination group (n=14 in each).

Dance combined with magnetic pulse stimulates the ability of walk and balance in elder people.

Objective: Observe the treatment effect on elderly people's waling and balance ability under the stimulation and intervention of waving dance combined with magnetic pulse.

Method: 96 elderly people are Involved in the research and the random number table method is divided into observation group and control group; there are 48 people in each group. The control group on the basis of routine daily activities increase waving dance for training treatment; the observation group take training treatment together with the control group, plus magnetic pulse for stimulation treatment.

Effect of Tai Chi exercise in combination with auricular plaster on patients with lumbar muscle strain.

Objective: observe the effect of Tai Chi exercise on the patients with the chronic lumbar muscle strain under the intervention treatment of auricular plaster.

Methods: 74 middle-aged and elderly patients, suffering from the chronic lumbar muscle strain, are randomly and equally divided into an observation group and a control group, with 37 patients in each group. The patients in the control group do Tai Chi exercise, while those in the observation group are treated by the auricular plaster therapy in addition to Tai Chi exercise.

Glutamine supplementation and immune function during heavy load training.

Athletes with heavy training loads are prone to infectious illnesses, suggesting that their training may suppress immune function. This study sought to determine whether supplementation with the amino acid glutamine, which supports immune health, alters immune function in athletes during heavy load training. 24 athletes were randomly assigned to either an experimental group (n = 12) or a control group (n = 12).

Treatment effect of the method of Tai Chi exercise in combination with inhalation of air negative oxygen ions on hyperlipidemia.

Objective: To observe the improvement effect of the treatment method of Tai Chi exercise in combination with inhalation of the air negative oxygen ions on the blood lipid indicator of the patient suffering from the hyperlipidemia.

Methods: 56 patients, who are diagnosed with hyperlipidemia, are the study objects and divided into an observation group and a control group by the random number method. Each group consists of 28 patients.

Combined effects of astragalus soup and persistent Taiji boxing on improving the immunity of elderly women.

Objective: To observe the combined effects of astragalus soup and persistent Taiji boxing on improving the immunity of women of advanced years.

Design: 120 elderly women lacking daily exercise were chosen as the study subjects. By using the table of random numbers, they were then divided into the control group and the experiment group, consisting of 60 each.

Effect of Tai-chi exercise on lower limb muscle strength, bone mineral density and balance function of elderly women.

Unlabelled: To study the effect of Tai-chi exercise on lower limb muscle strength, bone mineral density and balance function of elderly female, 105 urban elderly women, who do insufficient exercise in daily life, are selected as the subject and randomly divided into an observation group (Tai Chi Group), a control group I (Dance Group) and a control group II (Walking Group). Each group is consists of 35 women. Among them, the women in the observation group do Tai-chi exercise once a day, while the women in the control group I dance once a day and in the control group II stick to brisk walking once a day.

Effect of Tai Chi exercise on the physical and mental health of the elder patients suffered from anxiety disorder.

Objective: Observe the effect of Tai Chi exercise on the rehabilitation of elder patients suffered from the anxiety disorder.

Methods: 32 elder patients suffered from the anxiety disorder are randomly divided into the experimental group and the control group and each of them consists of 16 patients. The control group only receives the drug therapy, while the experimental group is treated with Tai Chi exercise in addition to the drug therapy.

Therapeutic effect of transplanting bone mesenchymal stem cells on the hind limbs' motor function of rats with acute spinal cord injury.

Purpose: To research the therapeutic effect of the allograft of bone mesenchymal stem cells (BMSCs) on hind limbs' motor function of rats that underwent acute injury to their spinal nerve.

Design: 40 Wistar rat samples with the acute injury to the spinal cord were established and divided into the transplantation group and the control group, 20 for each group; One week after injury, BMSCs were slowly injected into the center of the injured spinal cord of the rats, and the physiological saline was injected into the control group.

Main Outcome Measures: The rehabilitation of the motor function of the rats' hind limbs was observed; furthermore, eight weeks after the injury, the protein disparity of the nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) between the two groups of rats was noted.

Relaxation training during chemotherapy for breast cancer improves mental health and lessens adverse events.

Objective: Mental health issues like anxiety and depression and other adverse events often accompany chemotherapy for breast cancer and can result in reduced quality of life for patients. The present study was aimed to determine whether relaxation training intervention reduces anxiety and other adverse reactions during chemotherapy in patients with breast cancer.

Methods: Using a prospective, randomized study design, patients with breast cancer were divided into a control group (n=50) and an experimental group (n=50).

Association study of dimethylarginine dimethylaminohydrolase 2 gene polymorphisms and coronary heart disease.

While a number of genetic and environmental risk factors for coronary heart disease (CHD) have been identified, the list of potential risk factors remains long. One candidate is dimethylarginine dimethylaminohydrolase (DDAH2), which is known to be polymorphic in humans. The gene product indirectly increases the endogenous production of nitric oxide, an anti-atherogenic molecule.

Correlation of von Willebrand factor gene polymorphism and coronary heart disease.

To characterize von Willebrand factor (vWF) gene polymorphisms at site A1381T and the correlation of plasma vWF levels with coronary heart disease, the vWF genotypes at site A1381T were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in patients diagnosed with coronary heart disease and normal controls (n=110 per group), and plasma vWF levels were measured by enzyme‑linked immunosorbent assay. The results showed that the plasma vWF levels were higher in the experimental group than in the control group and had no association with gender (t=11.69, p<0.