Simultaneous determination of 13 paralytic shellfish toxins and tetrodotoxin in marine shellfish by porous graphitic carbon solid-phase extraction and hydrophilic interaction chromatography-tandem mass spectrometry.

The lethal neurotoxins, paralytic shellfish toxins (PSTs), and tetrodotoxin (TTX) have recently been found in marine shellfish from many coastal states. Herein, we applied a sensitive and reliable ultra-performance hydrophilic interaction chromatography (HILIC)-tandem mass spectrometry (MS) method to determine 13 PSTs and TTX in marine shellfish using a porous carbon solid-phase extraction (SPE). This in-house validation study required the development of a novel chromatographic separation using a HILIC-Z column, which was necessary to retain highly polar compounds.

Immunotoxicity of pentachlorophenol to a marine bivalve species and potential toxification mechanisms underpinning.

The ubiquitous presence of pentachlorophenol (PCP) in ocean environments threatens marine organisms. However, its effects on immunity of marine invertebrates at environmentally realistic levels are still largely unknown. In this study, the immunotoxicity of PCP to a representative bivalve species was evaluated.

Pollution level and health risk assessment of the total petroleum hydrocarbon in marine environment and aquatic products: a case of China.

To evaluate the pollution level and health risk of total petroleum hydrocarbon (TPH), seawater, sediments, and aquatic organisms were sampled from the southern sea area of Zhejiang Province (Yangtze River Delta, China) between 2017 and 2019. TPH was widely present in the aquatic environment and products, and its concentration was highly variable. The average value of pollution index (PI) exceeded 1 from 2017 to 2018, and 45.

Spirulina phycocyanin induces differential protein expression and apoptosis in SKOV-3 cells.

The present study was designed to determine the effects of phycocyanin (PC) on Human ovarian cancer SKOV-3 cells and the underlying molecular mechanisms of action. The inhibitory effects of PC on the cell proliferation were detected by MTT assay. The IC50 values of PC were 182.