Publications by authors named "Rongling Li"

Article Synopsis
  • * A study examined genetic parameters of semen and conformation traits in Holstein bulls, revealing heritabilities ranging from low (0.06) to moderate (0.69) across various traits.
  • * Strong genetic correlations among semen traits suggest that improving semen quality through selective breeding is possible, with SC serving as a valuable trait for indirect selection in breeding programs.
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  • Clostridioides difficile infection (CDI) is a major cause of diarrhea in hospitals across North America and Europe, leading to significant health risks.
  • Previous risk factors don't fully explain why some people get CDI while others don't, suggesting a genetic component to susceptibility.
  • A study involving nearly 20,000 participants found that variations in the DRB locus of the MHC (HLA) II region may increase the likelihood of developing CDI, indicating that genetic factors could influence how the body responds to this infection.
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Objectives: This study was performed in the frame of a more extensive study dedicated to the integrated analysis of the single-cell transcriptome and chromatin accessibility datasets of peripheral blood mononuclear cells (PBMCs) with a large-scale GWAS of 45 complex traits in Chinese Holstein cattle. Lipopolysaccharide (LPS) is a crucial mediator of chronic inflammation to modulate immune responses. PBMCs include primary T and B cells, natural killer (NK) cells, monocytes (Mono), and dendritic cells (DC).

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Introduction: Clinical mastitis (CM) is one of the most common diseases of dairy cows globally, has a complex aetiology and recurs easily. is a frequently isolated pathogen responsible for bovine mastitis and remains difficult to eradicate.

Material And Methods: To characterise the transcriptional profiles of dairy cows infected by , we performed an RNA-seq analysis of peripheral blood leukocytes in lactating Chinese Holstein dairy cows with CM and did the same with healthy cows' samples as controls.

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Background: Gram-negative bacteria are important pathogens in cattle, causing severe infectious diseases, including mastitis. Lipopolysaccharides (LPS) are components of the outer membrane of Gram-negative bacteria and crucial mediators of chronic inflammation in cattle. LPS modulations of bovine immune responses have been studied before.

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Genomic medicine aims to improve health using the individual genomic data of people to inform care. While clinical utility of genomic medicine in many monogenic, Mendelian disorders is amply demonstrated, clinical utility is less evident in polygenic traits, e.g.

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Background: Unbiased estimates of penetrance are challenging but critically important to make informed choices about strategies for risk management through increased surveillance and risk-reducing interventions.

Methods: We studied the penetrance and clinical outcomes of 7 breast cancer susceptibility genes (, , , , , , and ) in almost 13 458 participants unselected for personal or family history of breast cancer. We identified 242 female participants with pathogenic or likely pathogenic variants in 1 of the 7 genes for penetrance analyses, and 147 women did not previously know their genetic results.

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  • Current knowledge of donkey evolution is incomplete, but researchers have created a chromosome-level reference genome for the Dezhou donkey and analyzed genomes from 126 domestic donkeys and 7 wild asses to gain insights.
  • Population genetic studies show that donkeys were domesticated in Africa, revealing reduced Y chromosome variability and differences in paternal and maternal ancestries due to reproductive management practices.
  • The research also identifies a genetic cause for coat color differences, demonstrating that a single base pair deletion near the TBX3 gene leads to the black or chestnut coat colors in domestic donkeys, diverging from the diluted gray pigmentation seen in wild asses.
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The random regression test-day model has become the most commonly adopted model for routine genetic evaluations in dairy populations, which allows accurately accounting for genetic and environmental effects over lactation. The objective of this study was to explore appropriate random regression test-day models for genetic evaluation of milk yield in a Holstein population with a relatively small size, which is the common situation in regional or independent breeding companies to preform genetic evaluation. Data included 419,567 test-day records from 54,417 cows from the first lactation.

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Carotid artery atherosclerotic disease (CAAD) is a risk factor for stroke. We used a genome-wide association (GWAS) approach to discover genetic variants associated with CAAD in participants in the electronic Medical Records and Genomics (eMERGE) Network. We identified adult CAAD cases with unilateral or bilateral carotid artery stenosis and controls without evidence of stenosis from electronic health records at eight eMERGE sites.

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Controllers employing optimal control strategies will path the way to enable flexible operations in future power grids. As buildings will increasingly act as prosumers in future power grids, optimal control of buildings' energy consumption will play a major role in providing flexible operations. Optimal controllers such as model predictive controller are able to manage buildings' operations and to optimise their energy consumption.

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Thermal comfort modeling has been of interest in built environment research for decades. Mostly the modeling approaches focused on an average response of a large group of building occupants. Recently, the focus has been shifted towards personal comfort models that predict individuals' thermal comfort responses.

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Background: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with a genetically heterogeneous background that can be accompanied by considerable morbidity and attendant health care costs. The pathogenesis and progression of NAFLD is complex with many unanswered questions. We conducted genome-wide association studies (GWASs) using both adult and pediatric participants from the Electronic Medical Records and Genomics (eMERGE) Network to identify novel genetic contributors to this condition.

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Background: Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) and their target binding sites affect miRNA function and are involved in biological processes and diseases, including bovine mastitis, a frequent inflammatory disease. Our previous study has shown that bta-miR-2899 is significantly upregulated in the mammary gland tissue of mastitis-infected cow than that of healthy cows.

Results: In the present study, we used a customized miRNAQTLsnp software and identified 5252 SNPs in 691 bovine pre-miRNAs, which are also located within the quantitative trait loci (QTLs) that are associated with mastitis and udder conformation-related traits.

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Objective: We describe a stratified sampling design that combines electronic health records (EHRs) and United States Census (USC) data to construct the sampling frame and an algorithm to enrich the sample with individuals belonging to rarer strata.

Materials And Methods: This design was developed for a multi-site survey that sought to examine patient concerns about and barriers to participating in research studies, especially among under-studied populations (eg, minorities, low educational attainment). We defined sampling strata by cross-tabulating several socio-demographic variables obtained from EHR and augmented with census-block-level USC data.

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The Electronic Medical Records and Genomics (eMERGE) network is a network of medical centers with electronic medical records linked to existing biorepository samples for genomic discovery and genomic medicine research. The network sought to unify the genetic results from 78 Illumina and Affymetrix genotype array batches from 12 contributing medical centers for joint association analysis of 83,717 human participants. In this report, we describe the imputation of eMERGE results and methods to create the unified imputed merged set of genome-wide variant genotype data.

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Background: The factors influencing parents' willingness to enroll their children in biobanks are poorly understood. This study sought to assess parents' willingness to enroll their children, and their perceived benefits, concerns, and information needs under different consent and data-sharing scenarios, and to identify factors associated with willingness.

Methods: This large, experimental survey of patients at the 11 eMERGE Network sites used a disproportionate stratified sampling scheme to enrich the sample with historically underrepresented groups.

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Neutrophil cytosolic factor 4 (NCF4) is a member of the nicotinamide adenine dinucleotide phosphate oxidase subunit. This protein functions as an essential factor in the host defense against the progression of bacterial infection. To explore the variability of the NCF4 gene and the susceptibility of cows to mastitis, NCF4 functional single nucleotide polymorphism (SNP) of the 3' untranslated region (3'UTR) and its targeted microRNA (miRNA) were identified.

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We examined the Institutional Review Board (IRB) process at 9 academic institutions in the electronic Medical Records and Genomics (eMERGE) Network, for proposed electronic health record-based genomic medicine studies, to identify common questions and concerns. Sequencing of 109 disease related genes and genotyping of 14 actionable variants is being performed in ~28,100 participants from the 9 sites. Pathogenic/likely pathogenic variants in actionable genes are being returned to study participants.

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Skin temperature is a challenging parameter to predict due to the complex interaction of physical and physiological variations. Previous studies concerning the correlation of regional physiological characteristics and body composition showed that obese people have higher hand skin temperature compared to the normal weight people. To predict hand skin temperature in a different environment, a two-node hand thermophysiological model was developed and validated with published experimental data.

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Article Synopsis
  • Most genetic studies on body mass index (BMI) have focused on European populations, leading to gaps in understanding how these genetic loci affect BMI in other racial and ethnic groups.
  • This research aimed to assess the applicability of 170 established BMI genetic variants across diverse US populations and fine-map 36 BMI loci with a large sample from multiple ancestries.
  • Findings indicated that about 25% of previously identified BMI SNPs showed consistent effects across different ethnic groups, highlighting the significance of using multiethnic genomic data to better understand genetic contributions to BMI.
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Background: African Americans (AA) are disproportionately affected by hypertension-related health disparities. Apolipoprotein L1 (APOL1) risk variants are associated with kidney disease in hypertensive AAs.

Objectives: This study assessed the APOL1 risk alleles' association with blood pressure traits in AAs.

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Resistant hypertension is defined as high blood pressure that remains above treatment goals in spite of the concurrent use of three antihypertensive agents from different classes. Despite the important health consequences of resistant hypertension, few studies of resistant hypertension have been conducted. To perform a genome-wide association study for resistant hypertension, we defined and identified cases of resistant hypertension and hypertensives with treated, controlled hypertension among >47,500 adults residing in the US linked to electronic health records (EHRs) and genotyped as part of the electronic MEdical Records & GEnomics (eMERGE) Network.

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