Discovery of HyT-Based Degraders of CDK9-Cyclin T1 Complex.

Direct modulation of the non-kinase functions of cyclin and CDK-cyclin complexes poses challenges. We utilize hydrophobic tag (HyT) based small-molecule degraders induced degradation of cyclin T1 and its corresponding kinase partner CDK9. LL-CDK9-12 demonstrated the most potent and selective degradation ability, with DC values of 0.

Discovery of : A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex.

The CDK8-cyclin C complex is an important anti-tumor target, but unlike CDK8, cyclin C remains undruggable. Modulators regulating cyclin C activity directly are still under development. Here, a series of hydrophobic tagging-based degraders of the CDK8-cyclin C complex were designed, synthesized, and evaluated to identify the first dual degrader, , which induced selective and synchronous degradation of CDK8 and cyclin C.

Laser-induced acoustic desorption coupled with electrospray ionization mass spectrometry for rapid qualitative and quantitative analysis of glucocorticoids illegally added in creams.

We present a strategy for the coupling of laser-induced acoustic desorption (LIAD) with electrospray ionization (ESI) mass spectrometry. Different from desorption electrospray ionization (DESI) or paper spray ionization (PSI), the technique decouples the desorption of analytes from the subsequent ionization. The desorption is initiated by a shock wave induced in 10 μm titanium (Ti) foil coated with the sample, irradiated from the rear side by a laser beam, and then the desorbed neutral analytes are post-ionized by ESI and finally characterized by quadrupole/time-of-flight (Q-TOF) mass spectrometry (MS).

Raman study of the photoinduced behavior of dye molecules on TiO() single crystal surfaces.

In dye-sensitized solar cells (DSSCs), the TiO/dye interface significantly affects photovoltaic performance. However, the adsorption and photoinduced behavior of dye molecules on the TiO substrate remains unclear. Herein, shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) was used to study the adsorption and photoinduced behavior of dye (N719) molecules on different TiO() surfaces.

Metal Probe Microextraction Coupled to Dielectric Barrier Discharge Ionization-Mass Spectrometry for Detecting Drug Residues in Organisms.

In this study, a novel method for the direct coupling of metal probe microextraction (MPME) and a dielectric barrier discharge ionization (DBDI) source with mass spectrometry (MS) is reported. Analytes adsorbed on a tungsten needle were directly transferred to the DBDI source via rapid thermal desorption, which resulted in a limit of detection as low as 8 pg/mL. This is in part due to the "active capillary" configuration of the plasma ion source, where the efficiency of ion transfer to the MS is ∼100%.

Gold-catalyzed intermolecular oxidation of o-alkynylbiaryls: an easy and practical access to functionalized fluorenes.

A novel gold-catalyzed intermolecular oxidation of o-alkynylbiaryls has been developed. A variety of functionalized fluorenes are readily accessed by utilizing this non-diazo approach, thus providing a viable alternative to synthetically useful fluorenes.