Publications by authors named "Rongji Xu"
Article Synopsis
- Exosomes are important for cell communication and can be used as biomarkers in diagnosing and treating diseases, particularly cancer, but studying their nucleic acids has challenges.
- Researchers created ExMdb, a detailed database that includes information on exosomal nucleic acids, gene-disease links, and a wide range of associated biomarkers, pulling from existing research and datasets.
- The database comprises extensive experimental data and high-throughput datasets to analyze variations in exosomal molecules, aiding the understanding of complex diseases and enhancing the discovery of new diagnostic and therapeutic approaches.
Background: Patients with epithelial ovarian carcinoma (EOC) are usually diagnosed at an advanced stage with tumour cell invasion. However, identifying the underlying molecular mechanisms and biomarkers of EOC proliferation and invasion remains challenging.
Results: Herein, we explored the relationship between tumour microenvironment (TME) reprogramming and tissue invasion based on single-cell RNA sequencing (scRNA-seq) datasets.
ENCD (http://www.bio-server.cn/ENCD/) is a manually curated database that provides comprehensive experimentally supported associations among endocrine system diseases (ESDs) and long non-coding ribonucleic acid (lncRNAs).
View Article and Find Full Text PDFDuring the complex process of tumour development, the unique destiny of cells is driven by the fine-tuning of multilevel features such as gene expression, network regulation and pathway activation. The dynamic formation of the tumour microenvironment influences the therapeutic response and clinical outcome. Thus, characterizing the developmental landscape and identifying driver features at multiple levels will help us understand the pathological development of disease in individual cell populations and further contribute to precision medicine.
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