Publications by authors named "Ronghui Li"

Immune encephalitis (IE) is an immune-mediated adverse events (irAEs) linked to nivolumab therapy, and its clinical characteristics remain unclear. This study aimed to analyze the clinical patterns of nivolumab-induced IE to inform diagnosis, treatment, and prevention strategies. We conducted a retrospective analysis of nivolumab-induced IE by reviewing case reports from the database until October 31, 2024.

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Tumor cells possess sophisticated strategies to circumvent immune detection, including the modulation of endogenous immune checkpoints, particularly those within the B7 family. Elucidating the mechanisms that govern the induction of B7 family molecules is crucial for the advancement of immunotherapy. Lysine lactylation (Kla), a newly identified epigenetic modification, is suggested may play a role in reshaping the tumor microenvironment and facilitating immune evasion.

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Background: Inflammatory bowel disease (IBD) is a rare adverse effect linked to secukinumab, with limited clinical data available. This study aimed to analyze the clinical features of secukinumab-induced IBD and to offer recommendations for the careful administration of secukinumab.

Methods: We conducted a retrospective analysis by gathering case reports and case series of secukinumab-induced IBD through a database search, with data collected until September 30, 2024.

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This study evaluates the clinical impact of comprehensive nursing care on senior patients suffering from postherpetic neuralgia (PHN), a chronic neuropathic pain condition resulting from the reactivation of the varicella-zoster virus. A total of 102 elderly patients diagnosed with PHN and treated at our hospital were divided into two groups: the control group, which received conventional nursing care, and the intervention group, which received comprehensive nursing care. Comparative analyses were conducted on pain levels, sleep quality, symptoms of depression and anxiety before and after the intervention.

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Article Synopsis
  • A circuit-based gene therapy has effectively reversed key symptoms of Parkinson's disease in animal models, including mice and primates.
  • This approach targets dopamine receptor D-expressing neurons through a combination of adeno-associated virus (AAV) delivery and chemogenetic techniques.
  • The research includes a step-by-step guide for AAV injection, creating PD models in primates, and evaluating the therapy's impact on motor symptoms.
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Background: Patient and Family-Centered Care (PFCC) interventions are increasingly recognized as a viable approach to address various mental health issues among patients in Intensive Care Units (ICUs). Therefore, this review aims to estimate the effect of Patient and Family-Centered Care Interventions on specific outcomes in adult patients admitted to Intensive Care Units (ICUs).

Methods: We systematically searched four major databases for parallel arm Randomized Controlled Trials (RCTs).

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Multifunctional nitrogen-doped carbon dots (N-CDs) were synthesized, and the morphology, composition, and spectral properties of N-CDs were characterized by multiple characterization techniques. The inhibition of β-amyloid (Aβ) peptide aggregation and the destruction of the Aβ fibril structure by N-CDs were also studied. The conformational transition and morphology of Aβ in the presence of N-CDs were monitored by far-UV circular dichroism (CD) spectroscopy and transmission electron microscopy (TEM).

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In recent years, the integration of immunotherapy in the treatment of lung cancer has marked a significant evolution in the field. This is evidenced by the surge in the volume of scientific publications, reflecting rapid advances over time. This paper presents a bibliometric analysis of lung cancer and immunotherapy research from January 2012 to December 2022, drawing on the Web of Science literature database and using the citexs data analysis platform to examine the shifts in topic hotspots over the decade.

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Contemporary research on ichthyological behavior predominantly investigates underwater environments. However, the intricate nature of aquatic ecosystems often hampers subaqueous observations of fish behavior due to interference. Transitioning the observational perspective from subaqueous to supra-aquatic enables a more direct assessment of fish physiology and habitat conditions.

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Intraoperative surgical margin assessment remains a challenge during breast-conserving surgery. Here, we report a combined strategy of immuno-positron emission tomography (PET) for preoperative detection of breast cancer and guided assessment of margins in breast-conserving surgery through second near-infrared (NIR-II) fluorescence imaging of trophoblastic cell surface antigen 2 (TROP2). We demonstrated that the intensity of PET signals in the tumors was nearly five times higher than in normal breast tissue with a zirconium-89 tracer conjugated to sacituzumab govitecan (SG) in a mouse spontaneous breast cancer model, enabling the identification of tumors.

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Understanding the risks of planktonic algal proliferation and its environmental causes is crucial for protecting water quality and controlling ecological risks. Reservoirs, due to the characteristics of slow flow rates and long hydraulic retention times, are more prone to eutrophication and algal proliferation. Chlorophyll-a (Chl-a) serves as an indicator of planktonic algal biomass.

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Article Synopsis
  • - Recent studies suggest that sodium-glucose cotransporter-2 inhibitors (SGLT-2i) may be linked to acute pancreatitis (AP), but details on the clinical characteristics of this association were not well-defined.
  • - This research reviewed case reports and clinical studies up to December 2023, including 21 patients with a median age of 50.5, finding common symptoms like abdominal pain and notable lab results indicating elevated lipase and amylase levels.
  • - The study concluded that SGLT-2i can cause AP, highlighting the need for doctors to consider these medications as a potential cause of pancreatitis when diagnosing patients.
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  • Soil acidification is a major challenge for sustainable tea industry development, prompting a review of 63 research articles on soil amendments.
  • A meta-analysis showed lime significantly raises soil pH by 18%, while rapeseed cake has a minimal effect of 2%.
  • The effectiveness of biochar varies with soil conditions, particularly showing an 11% increase in acidic soils, and specific types produced from animal waste can raise pH by 9-12%, highlighting potential strategies for improving tea plantation soil health.
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Multifunctional N, Fe-doped carbon dots (N, Fe-CDs) were synthesized by the one-step hydrothermal method using ferric ammonium citrate and dicyandiamide as raw materials. The N, Fe-CDs exhibited peroxidase-like (POD) activity by catalyzing the oxidization of 3,3',5,5'-tetramethylbenzidine (TMB) to the green oxidation state ox-TMB in the presence of hydrogen peroxide (HO). Subsequently, based on the POD activity of N, Fe-CDs, an efficient and sensitive colorimetric method for the detection of HO and ascorbic acid (AA) was established with a limit of detection of 0.

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Background: Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Multiple identified mutations in nexilin (NEXN) have been suggested to be linked with severe DCM. However, the exact association between multiple mutations of Nexn and DCM remains unclear.

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  • The article explores the JAK2/STAT3 pathway's involvement in various cardiovascular diseases, including conditions like myocardial fibrosis and atherosclerosis.
  • It discusses how natural compounds, especially from traditional Chinese medicine, can influence this pathway to potentially treat these diseases.
  • The JAK2 pathway displays dual roles in these diseases, indicating the need for further research to understand how different natural ingredients can regulate JAK2 for future clinical applications.
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Formation and extinction of thermal stratifications impact the reservoir ecosystems and have been closely influenced by meteorological and hydrological factors. However, quantifying the relative importance of these crucial environmental factors and mechanisms in reservoir regions characterized by various depths remain comparatively uninvestigated. Tianbao Reservoir is a typical monomictic warm and drinking water source reservoir in Southwest China.

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  • * A study identified 23 candidate genes related to this gene family in a particular plant's genome, analyzing their distribution across chromosomes, phylogenetic relationships, and expressions in different plant tissues.
  • * Key genes (7, 9, and 12) were found to be highly expressed in swollen tubers, confirmed to be present on the cell membrane, suggesting their involvement in tuber formation and offering insights for future research and molecular breeding.
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To investigate the mechanism of doxorubicin (DOX)-induced immunogenic cell death (ICD) and to improve immunotherapy efficacy. In this study, hybrid vesicles containing DOX (HV-DOX) were prepared by thin-film hydration with extrusion, and the formulated nanoparticles were characterized physically. Furthermore, experiments and animal models were used to investigate the efficacy and new mechanisms of chemotherapy combined with immunotherapy.

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Purpose: To explore the potential role of signal transducer and activator of transcription 5A (STAT5A) in the metastasis of breast cancer, and its mechanism of regulation underlying.

Methods And Results: TCGA datasets were used to evaluate the expression of STAT5A in normal and different cancerous tissues through TIMER2.0, indicating that STAT5A level was decreased in breast cancer tissues compared with normal ones.

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Biogas production causes vast amounts of biogas slurry (BS). Application of BS to croplands can substitute chemical fertilizers while result in higher ammonia emissions. Tremendous variation of ammonium concentration in different BSs induces imprecise substitution, while concentrated BS holds higher and more stable ammonium.

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The fungal Gβ-like protein has been reported to be involved in a variety of biological processes, such as mycelial growth, differentiation, conidiation, stress responses and infection. However, molecular mechanisms of the Gβ-like protein in regulating fungal development and pathogenicity are largely unknown. Here, we show that the Gβ-like protein gene Bcgbl1 in the gray mold fungus Botrytis cinerea plays a pivotal role in development and pathogenicity by regulating the mitogen-activated protein (MAP) kinases signaling pathways.

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Blackwater occurs every winter in reservoirs with Eucalyptus plantations. The complexation reaction between ferric iron (Fe) and Eucalyptus leachate tannic acid from logging residues (especially leaves) is the vital cause of water blackness. However, the effect of Eucalyptus leaf leaching on the dynamic of iron in sediments and its contribution to reservoir blackwater remain unclear.

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