Publications by authors named "Ronghua Zhang"

Bone homeostasis encompasses two interrelated aspects: bone remodeling and cartilage metabolism. Disruption of bone homeostasis can lead to the development of metabolic bone diseases such as osteoporosis and osteoarthritis. The maintenance of bone homeostasis is a complex process that does not solely rely on the functions of the bone tissue itself.

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Background: Maternal obstetric characteristics have a key role in determining the occurrence of pregnancy-related disorders and subsequent neonatal outcomes. We aimed to investigate the mediating impact of gestational diabetes mellitus (GDM) and hypertensive disorder of pregnancy (HDP) on the relationship between maternal advanced age, previous caesarean section, and the risk of either large for gestational age (LGA) or small for gestational age (SGA) infants.

Methods: We used data from a prospective multicentre cohort study conducted through China's National Maternal Near-miss Surveillance System from January 2012 to December 2021.

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Objective: To improve the accuracy of food intelligent recognition and weight estimation technology, establish a large-scale food image dataset.

Methods: Building large-scale food image and ingredient datasets based on web crawler technology, professional manual collection, and regular user uploads.

Results: A big dataset was constructed containing over 1.

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Purpose: This study aims to design an auxiliary segmentation model for thyroid nodules to increase diagnostic accuracy and efficiency, thereby reducing the workload of medical personnel.

Methods: This study proposes a Dual-Path Attention Mechanism (DPAM)-UNet++ model, which can automatically segment thyroid nodules in ultrasound images. Specifically, the model incorporates dual-path attention modules into the skip connections of the UNet++ network to capture global contextual information in feature maps.

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Postmenopausal osteoporosis, primarily driven by estrogen deficiency, is predominantly mediated through estrogen receptors such as ERα. However, the underlying mechanisms necessitate further investigation. In this study, we established an ERα-deficient model in rBMSCs to elucidate the role of ERα in osteogenic differentiation and miRNA expression profiles.

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Drynariae Rhizoma (DR) has been commonly used as a preventive and therapeutic agent for bone diseases. However, its pharmacological mechanisms have not been fully elucidated. Here, we aimed to investigate the effects of DR in a bilateral ovariectomized (OVX) rat model and explore the correlation with the gut microbiome.

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The development and progression of chronic lymphocytic leukemia (CLL) depend on genetic abnormalities and on the immunosuppressive microenvironment. We have explored the possibility that genetic drivers might be responsible for the immune cell dysregulation that shapes the protumor microenvironment. We performed a transcriptome analysis of coding and non-coding RNAs (ncRNAs) during leukemia progression in the Rag2γ MEC1-based xenotransplantation model.

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Article Synopsis
  • Pancreatic cancer has an immunosuppressive tumor microenvironment (TME) that aids in its progression, with recent focus on migrasomes—cell structures involved in signaling.
  • This study found that pancreatic cancer cells produce migrasomes (PCDMs) that significantly differ in their chemokine and protein content compared to the cancer cells themselves, highlighting their role in promoting cancer.
  • The research also showed that PCDMs can be taken up by macrophages, triggering them to secrete factors that suppress T cell activity and further enhance tumor growth, suggesting migrasomes as potential targets for new immunotherapy strategies.
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  • Bie Jia Jian pill (BJJP), a traditional Chinese medicine, is commonly used to treat chronic liver disease, but its specific mechanism for addressing hepatic fibrosis (HF) is not fully understood.
  • This study aims to investigate how BJJP interacts with HF by examining its effects on the intestinal microbiota and utilizing advanced techniques like 16S rRNA sequencing and network pharmacology.
  • Findings reveal that BJJP improves liver damage and fibrosis in rat models of HF by regulating gut microbiota and inhibiting the PI3K/AKT signaling pathway influenced by trimethylamine N-oxide (TMAO).
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  • This study focuses on improving photocatalytic performance to benefit the ecosystem by using advanced strategies like optimizing electronic structures and controlling crystallographic aspects.
  • A novel self-assembled bimetallic Fe/Mn-MOF with a SnS Z-scheme heterojunction photocatalyst was developed through a simple solvothermal method, achieving 91.4% degradation of tetracyclines in 80 minutes.
  • The research highlights the roles of interfacial heterojunctions, oxygen-active species, and degradation mechanisms, providing insights for designing efficient solar energy-converting photocatalysts.
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  • - The study analyzed the changes in dietary iodine intake in Zhejiang, highlighting a decrease in both the iodine concentration in salt and the proportion of households using iodized salt between 2010 and 2022.
  • - Median dietary iodine intake among residents dropped significantly, with a notable increase in those consuming below the estimated average requirement, indicating a potential public health concern.
  • - Despite salt still being the primary source of dietary iodine, its contribution to overall iodine intake has declined markedly, emphasizing the need for strategies to improve iodized salt consumption in the region.
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Background: Children's lives are increasingly mediated by digital technologies, yet evidence regarding the associations between internet use and depression is far from comprehensive and remains unclear.

Objective: This study aimed to investigate the dose-response association between internet use, including use time and addiction behaviors, and depressive symptoms among children and adolescents in Zhejiang Province.

Methods: Data were collected from a school-based health survey China Common Disease and Risk Factor Surveillance Among Students, encompassing 21,336 students in Zhejiang Province.

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  • Iodine deficiency is a known cause of goiter, but this study investigates how lifestyle factors may also contribute to its prevalence among children and adolescents in Zhejiang Province, China.
  • A survey of 2261 participants aged 6-17 found that 10.8% had goiter, with high urinary iodine concentration linked to lower goiter risk, while poor lifestyle habits like excessive screen time increased the risk.
  • The findings highlight the importance of maintaining adequate iodine levels and promoting healthy lifestyle habits to prevent goiter, suggesting that public health efforts should focus on both nutrition and lifestyle changes.
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Introduction And Objective: His bundle pacing (HBP) could replace failed biventricular pacing (BVP) in guidelines (IIa Indication), but the high capture thresholds and backup lead pacing requirements limit its development. We assessed the efficacy and safety of HBP combined with atrioventricular node ablation (AVNA) for atrial fibrillation (AF) and compared with BVP and left bundle branch pacing (LBBP).

Methods: We reviewed PubMed, Embase, Web of Science, and Cochrane Library databases on left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) score, QRS duration (QRSd), and pacing threshold.

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  • * The research revealed that 43.39% of outbreaks were linked to wild mushroom toxins, which also resulted in the highest rates of hospitalization and death, while bacterial infections made up 16.23% of cases.
  • * Various etiological factors were identified across 11 prefectures, with differences in the types of outbreaks; improper food handling and storage were common causes, emphasizing the need for targeted prevention strategies.
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This paper proposes an optimization scheme for the layout of irregular warehouse spaces based on a class-based storage strategy. Firstly, we transform the irregular warehouse space into several regular rectangular areas. Next, through the class-based storage strategy, we develop an algorithm that converts the non-linear clustering problem of homogeneous shelves into a linear selection problem of different sized regular shelf areas.

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  • * Results showed that in individuals with sufficient vitamin A, higher AIP was linked to increased total triiodothyronine (TT3), while those severely deficient in vitamin A had different responses in hormone levels and a heightened risk of subclinical hypothyroidism with elevated AIP.
  • * The risk linked to vitamin A deficiency and AIP was significantly greater in women and older adults, indicating a demographic difference in vulnerability to these health issues.
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  • This study investigates how psychological resilience (PR), perceived social support (PSS), and psychological distress affect sleep quality among healthcare professionals, emphasizing the importance of sleep for both their well-being and patient outcomes.
  • A survey of 454 medical staff revealed that PR positively influences sleep quality, while psychological distress negatively impacts it, acting as a key mediator in this relationship.
  • Interestingly, PSS did not directly mediate the PR-sleep quality link but instead worked alongside psychological distress to affect sleep quality, suggesting ways to improve sleep among medical staff through targeted support and resilience-building strategies.
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Objective: To explore the relationship between dietary quality and metabolic syndrome(MS) in the population aged 45 to 59 in Zhejiang Province.

Methods: Selecting the 45-59 year old population as the research object from the 2022 nutrition and health monitoring data of residents in Zhejiang Province. Dietary data was obtained by the 24-hour dietary review method on 3 consecutive days and the weighing method of household cooking oil and condiments, and dietary quality was evaluated using the China health diet index(CHDI), which was categorized into four groups according to quartiles of CHDI scores.

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Aims: This study aimed to explore the correlation between homeostasis model assessment of insulin resistance(HOMA-IR)and cardiometabolic risk index(CMRI) among different metabolic adults to evaluate the value of HOMA-IR in predicting cardiometabolic risk.

Methods: This cross-sectional study was conducted over 18 months (from August 1, 2020 to February 18, 2022) and included 1550 participants divided into non-metabolic syndrome (non-MetS) group (n = 628) and metabolic syndrome (MetS) group (n = 922) in three centers of China. Logistic regression analysis was employed to investigate the correlation between HOMA-IR, body fat percentage, BMI (body mass index), visceral fat index, waist-to-hip ratio, vitamin D, and CMRI.

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  • Childhood hypertension is becoming a worldwide health issue, and this study analyzed its prevalence and related factors in 2,373 Chinese children aged 8-14 from Pinghu, Zhejiang province.
  • The study found that 5.0% of the children had hypertension, with abnormal weight and obesity significantly increasing the risk, especially among those with central obesity.
  • Results suggest that managing weight and obesity is crucial for preventing childhood hypertension, highlighting the need for public health strategies focused on healthy weight among children.
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Dental invagination is an abnormality of the crown or root development induced during tooth germ development when the enamel-forming apparatus or epithelial root sheath overpopulates and folds into the papilla. In severe cases, the invaginated channels are connected to the pulp and periodontal tissues, often causing endodontic and periapical diseases. The complex anatomical pattern of this disease adds difficulty in its preoperative diagnosis and clinical operation.

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We aimed to assess dietary iodine intake and sources in Zhejiang Province a decade after a reduction in iodine concentration in iodized salt. Three-day 24 h dietary recall and household weighing were used, complemented by "Chinese Food Composition" data. Household water and salt samples were collected from 5890 residents and analyzed.

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