Non-recurrent right laryngeal nerve identified during endoscopic thyroidectomy via areolar approach: a case report.

Background: Nonrecurrent laryngeal nerve (NRLN) is a rare but significant anatomical variation in thyroid surgery, and lack of awareness of NRLN may lead to intraoperative injury. Here, we report a clinical case of NRLN discovered during endoscopic thyroid surgery via total areola approach in a 23-year-old female patient.

Case Presentation: A 23-year-old female patient presented with bilateral thyroid nodules for three years.

TOETVA: a single surgeon's learning curve and a case report of CASTLE thyroid tumor.

Background: Owing to the lack of visible scars, the transoral endoscopic thyroidectomy vestibular approach (TOETVA) offers superior aesthetic outcomes compared to conventional thyroidectomy. Carcinoma showing thymus-like differentiation (CASTLE) represents a rare thyroid gland neoplasm. This study aimed to explore the TOETVA learning curve and present a case report of CASTLE.

Screening of novel biomarkers for breast cancer based on WGCNA and multiple machine learning algorithms.

Background: Breast cancer (BC) ranks first in incidence among women, with approximately 2 million new cases per year. Therefore, it is essential to investigate emerging targets for BC patients' diagnosis and prognosis.

Methods: We analyzed gene expression data from 99 normal and 1,081 BC tissues in The Cancer Genome Atlas (TCGA) database.

First-principles determination of the crystallography of the low-temperature phase for NbRu and TaRu shape memory alloys.

The crystallography of the low-temperature phases (β'') for shape memory alloys (NbRu and TaRu) has been debated for decades. Though a 2/ monoclinic structure has been proposed for the β'' phase, the proposed structure is not able to completely represent the measured diffraction data. In this work, the crystallography of the β'' phase was investigated by first-principles calculations.

Co-Ni Basic Carbonate Nanowire/Carbon Nanotube Network With High Electrochemical Capacitive Performance via Electrochemical Conversion.

In this work, the Co-Ni basic carbonate nanowires were grown on carbon nanotube (CNT) network through a facile chemical bath deposition method, which could be further converted into active hydroxide via cyclic voltammetry strategy. A series of carbonate nanowire/nanotube with different Co/Ni ratio revealed the different growth status of the nanowires on CNT network. The nanostructures of the as-synthesized samples were examined via powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) techniques.

SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane.

Background: HER2-positive breast cancer is usually associated to the more aggressive progression and the worse prognosis, but the mechanism underlying the innate resistance to HER2-targeted therapy remains elusive. The scaffold protein SH3-domain-binding glutamic acid-rich protein-like protein (SH3BGRL) is indicated as a tumor suppressor in some cancers, but it is highly expressed in breast cancers. Here we characterized the tumorigenic function of SH3BGRL in HER2-expressing breast cancer cells and the subsequent effect in HER2-targeted therapies.

PCBP1 depletion promotes tumorigenesis through attenuation of p27 mRNA stability and translation.

Background: Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlying mechanism in tumorigenesis remains elusive.

Methods: We performed a transcriptome-wide screen to identify novel bounding mRNA of PCBP1.

Clinical significance and prognostic value of Nek2 protein expression in colon cancer.

Objective: To determine the expression of NIMA-related kinase NEK2 and evaluate its clinical value in colon cancer.

Method: Sixty specimens of colon cancer, 30 specimens of paracancerous colon tissues and 10 specimens of normal colon tissues conventionally resected in surgery at the Second Affiliated Hospital of Nantong University from February 2006 to February 2014 were collected. These tissues were detected for the expression of Nek2 using Western Blot and immunohistochemical staining.

Enhancing the oxygen permeation rate of Zr(0.84)Y(0.16)O(1.92)-La(0.8)Sr(0.2)Cr(0.5)Fe(0.5)O(3-δ) dual-phase hollow fiber membrane by coating with Ce(0.8)Sm(0.2)O(1.9) nanoparticles.

Zr0.84Y0.16O1.

Preparation and characterization of polar polymeric adsorbents with high surface area for the removal of phenol from water.

Preparation of methyl methacrylate (MMA)/divinylbenzene (DVB) and ethylene glycol dimethacrylate (EGDMA)/DVB copolymers via suspension polymerization yielded precursors which possess residual vinyl groups. Post-crosslinking of appropriate dichloroethane swollen precursors without external crosslinking agent in the presence of anhydrous ferric chloride (FeCl(3)) yielded post-crosslinked resins with high surface area and suitable polarity. FT-IR spectrum indicated that increasing the proportion of MMA or EGDMA in monomer mixtures notably reduces the amount of the pendant vinyl groups onto the matrix of the precursors.

LCAT-null mice develop improved hepatic insulin sensitivity through altered regulation of transcription factors and suppressors of cytokine signaling.

We previously reported that LCAT-deficient mice develop not only low HDL-cholesterol but also hypertriglyceridemia, hepatic triglyceride (TG) overproduction, and, unexpectedly, improved hepatic insulin sensitivity and reduced hepatic TG content. Here, we examined the mechanistic links underlying this apparent paradox. The LDL receptor-deficient (Ldlr)(-/-)xLcat(-/-) mouse model and age- and sex-matched Ldlr(-/-)xLcat(+/+) littermates, both in C57Bl/6 background, were employed.