Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment.

Purpose: Oxidative phosphorylation (OXPHOS) is an aerobic metabolic mechanism, and its dysfunction plays an important role in the pathological changes of ischemic diseases. However, systematic studies on the occurrence of retinal detachment (RD) are lacking.

Methods: Single-cell RNA sequencing (scRNA-seq) of the human retina was performed to detect the metabolic changes of various retinal cells after RD.

NEWS, SIRS and qSOFA criteria for predicting sepsis and sepsis with high risk of death in emergency room: A comparison study and improved predictive models based on local data from CETAT and MIMIC-IV databases.

Early identification of sepsis in emergency department patients is critical for initiating timely interventions, highlighting the need for effective predictive scoring systems. A retrospective observational study was conducted using data from the CETAT database collected between December 2019 and October 2021. The study evaluated how well the systemic inflammatory response syndrome (SIRS), quick Sepsis-related Organ Failure Assessment (qSOFA), and National Early Warning Score (NEWS) scoring systems, along with logistic regression models, predict sepsis, and high-risk sepsis in emergency department patients.

The causal effect of oxidative stress on the risk of glaucoma.

Glaucoma is a complex multifactorial disease. Oxidative stress has been implicated in its pathogenesis. However, establishing a causal relationship between oxidative stress and glaucoma is challenging due to confounding and reverse causality.

Effect of the gut microbiome in glaucoma risk from the causal perspective.

Objective: Evidence from observational studies has reported possible associations between the gut microbiome (GM) and glaucoma. However, the causal effect of GM on glaucoma risk remains to be determined.

Methods And Analysis: We conducted two-sample bidirectional Mendelian randomisation (MR) analyses to explore the causal association between GM and glaucoma.

Quantum digital signature with unidimensional continuous-variable against the measurement angular error.

The continuous-variable quantum digital signature (CV-QDS) scheme relies on the components of quantum key generation protocol (KGP) to negotiate classical signature, which is more compatible with optical fibers. Nevertheless, the measurement angular error of heterodyne detection or homodyne detection will cause security issues when performing KGP in the distribution stage. For that, we propose to utilize unidimensional modulation in KGP components, which only requires to modulate single quadrature and without the process of basis choice.

Single-cell profiling reveals Müller glia coordinate retinal intercellular communication during light/dark adaptation via thyroid hormone signaling.

Light adaptation enables the vertebrate visual system to operate over a wide range of ambient illumination. Regulation of phototransduction in photoreceptors is considered a major mechanism underlying light adaptation. However, various types of neurons and glial cells exist in the retina, and whether and how all retinal cells interact to adapt to light/dark conditions at the cellular and molecular levels requires systematic investigation.

TLR2-hif1α-mediated glycolysis contributes to pyroptosis and oxidative stress in allergic airway inflammation.

As a pattern recognition receptor which activates innate immune system, toll-like receptor 2 (TLR2) has been reportedly mediates allergic airway inflammation (AAI), yet the underlying mechanism remains elusive. Here, in a murine AAI model, TLR2 mice showed decreased airway inflammation, pyroptosis and oxidative stress. RNA-sequencing revealed that allergen-induced hif1 signaling pathway and glycolysis were significantly downregulated when TLR2 was deficient, which were confirmed by lung protein immunoblots.

Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress.

Succinate dehydrogenase (SDH) is a heterotetrameric enzyme complex belonging to the mitochondrial respiratory chain and uniquely links the tricarboxylic acid (TCA) cycle with oxidative phosphorylation. Cancer-related SDH mutations promote succinate accumulation, which is regarded as an oncometabolite. Post-translational modifications of SDH complex components are known to regulate SDH activity, although the contribution of SUMOylation remains unclear.

The single-atom iron nanozyme mimicking peroxidase remodels energy metabolism and tumor immune landscape for synergistic chemodynamic therapy and photothermal therapy of triple-negative breast cancer.

Chemotherapy, as one main strategy to relieve tumor progression, has a weak effect on triple-negative breast cancer (TNBC) chest wall metastasis. The development of near-infrared (NIR) light-responsive nanomaterials for chemodynamic therapy (CDT) and photothermal therapy (PTT) is a promising platform but still challenging in biomedicine. This study reports a peroxidase mimicking nanozyme (Fe-N-C SAzyme) against TNBC by CDT and PTT.

Bioinformatics analysis reveals potential biomarkers associated with the occurrence of intracranial aneurysms.

To better understand the molecular mechanisms of intracranial aneurysm (IA) pathogenesis, we used gene coexpression networks to identify hub genes and functional pathways associated with IA onset. Two Gene Expression Omnibus (GEO) datasets encompassing intracranial aneurysm tissue samples and cerebral artery control samples were included. To discover functional pathways and potential biomarkers, weighted gene coexpression network analysis was employed.

LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis.

It is known that the long noncoding RNAs (lncRNA) MALAT1 is associated with tumorigenesis and progression in various cancers; however, its functions and mechanisms in prostate cancer (PCa) initiation and progression are still unknown. In the present study, our findings revealed that MALAT1 plays a critical part in regulating PCa proliferation and glucose metabolism. Knockdown of MALAT1 affects the protein and mRNA levels of MYBL2.

Optimized Super-Wideband MIMO Antenna with High Isolation for IoT Applications.

A compact, low profile, multiple-input-multiple-output (MIMO) diversity antenna with super-wideband (SWB) characteristics has been proposed. The proposed antenna comprises four symmetric monopole-radiating elements printed on low-cost FR4 substrate with the slotted ground plane. The single antenna of a monopole structure and a quad-port MIMO antenna, with the dimensions of 30 × 20 mm and 60 × 55 mm, respectively, are ideal for IoT and high-speed data applications.

Prevents Periodontitis Induced by in Rats by Regulating -Defensins.

Objective: To study the preventive effect of () on periodontitis induced by () in rats.

Methods: Eighteen 8-week-old female rats were randomly divided into three groups: Sham group, Trehalose group, and SBT2171 (LH2171) group. We measured the distance of the cementoenamel junction-alveolar bone crest (CEJ-ABC) to evaluate alveolar bone resorption.

The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis.

Non-covalent complexes of glycolytic enzymes, called metabolons, were postulated in the 1970s, but the concept has been controversial. Here we show that a c-Myc-responsive long noncoding RNA (lncRNA) that we call glycoLINC (gLINC) acts as a backbone for metabolon formation between all four glycolytic payoff phase enzymes (PGK1, PGAM1, ENO1, and PKM2) along with lactate dehydrogenase A (LDHA). The gLINC metabolon enhances glycolytic flux, increases ATP production, and enables cell survival under serine deprivation.

Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism.

The NAD-dependent deacetylase Sirt1 has been implicated in the prevention of many age-related diseases, including cancer, type 2 diabetes, and cardiovascular disease. Resveratrol, a plant polyphenol, exhibits antiaging, antitumor, and vascular protection effects by activating Sirt1. However, the molecular mechanism of Sirt1 activation as induced by resveratrol remains unclear.

Performance Analysis and Optimization of a Cooperative Transmission Protocol in NOMA-Assisted Cognitive Radio Networks with Discrete Energy Harvesting.

In this paper, we propose a spectrum-sharing protocol for a cooperative cognitive radio network based on non-orthogonal multiple access technology, where the base station (BS) transmits the superimposed signal to the primary user and secondary user with/without the assistance of a relay station (RS) by adopting the decode-and-forward technique. RS performs discrete-time energy harvesting for opportunistically cooperative transmission. If the RS harvests sufficient energy, the system performs cooperative transmission; otherwise, the system performs direct transmission.

Potent Molecular Feature-based Neutralizing Monoclonal Antibodies as Promising Therapeutics Against SARS-CoV-2 Infection.

The 2019-2020 winter was marked by the emergence of a new coronavirus (SARS-CoV-2) related disease (COVID-19), which started in Wuhan, China. Its high human-to-human transmission ability led to a worldwide spread within few weeks and has caused substantial human loss. Mechanical antiviral control approach, drug repositioning, and use of COVID-19 convalescent plasmas (CPs) were the first line strategies utilized to mitigate the viral spread, yet insufficient.

DDIT3 Directs a Dual Mechanism to Balance Glycolysis and Oxidative Phosphorylation during Glutamine Deprivation.

Extracellular glutamine represents an important energy source for many cancer cells and its metabolism is intimately involved in maintaining redox homeostasis. The heightened metabolic activity within tumor tissues can result in glutamine deficiency, necessitating metabolic reprogramming responses. Here, dual mechanisms involving the stress-responsive transcription factor DDIT3 (DNA damage induced transcript 3) that establishes an interrelationship between glycolysis and mitochondrial respiration are revealed.

A Hybridization of Dragonfly Algorithm Optimization and Angle Modulation Mechanism for 0-1 Knapsack Problems.

The dragonfly algorithm (DA) is a new intelligent algorithm based on the theory of dragonfly foraging and evading predators. DA exhibits excellent performance in solving multimodal continuous functions and engineering problems. To make this algorithm work in the binary space, this paper introduces an angle modulation mechanism on DA (called AMDA) to generate bit strings, that is, to give alternative solutions to binary problems, and uses DA to optimize the coefficients of the trigonometric function.

Potency, Safety, and Pharmacokinetic Profiles of Potential Inhibitors Targeting SARS-CoV-2 Main Protease.

Effective, safe, and pharmacokinetically suitable drugs are urgently needed to curb the ongoing COVID-19 pandemic. The main protease or 3C-like protease (M or 3CL) of SARS-CoV-2 is considered an important target to formulate potent drugs corresponding to its crucial role in virus replication and maturation in addition to its relatively conserved active site. Promising baseline data on the potency and safety of drugs targeting SARS-CoV-2 M are currently available.

BAF Complex in Embryonic Stem Cells and Early Embryonic Development.

Embryonic stem cells (ESCs) can self-renew indefinitely and maintain their pluripotency status. The pluripotency gene regulatory network is critical in controlling these properties and particularly chromatin remodeling complexes. In this review, we summarize the research progresses of the functional and mechanistic studies of BAF complex in mouse ESCs and early embryonic development.

An Approach to Cryptography Based on Continuous-Variable Quantum Neural Network.

An efficient cryptography scheme is proposed based on continuous-variable quantum neural network (CV-QNN), in which a specified CV-QNN model is introduced for designing the quantum cryptography algorithm. It indicates an approach to design a quantum neural cryptosystem which contains the processes of key generation, encryption and decryption. Security analysis demonstrates that our scheme is security.

A Metamaterial-Based Compact Planar Monopole Antenna for Wi-Fi and UWB Applications.

Ultrawideband (UWB) antennas are widely used as core devices in high-speed wireless communication. A novel compact UWB monopole antenna with an additional narrow band for Wi-Fi applications comprising a metamaterial (MTM) is proposed in this paper. The antenna has a compact size of 27 × 33 mm and consists of a V-shaped slot with two rectangular slots in the radiation patch.

Practical Security Analysis of Reference Pulses for Continuous-Variable Quantum Key Distribution.

By manipulating the reference pulses amplitude, a security vulnerability is caused by self-reference continuous-variable quantum key distribution. In this paper, we formalize an attack strategy for reference pulses, showing that the proposed attack can compromise the practical security of CVQKD protocol. In this scheme, before the beam splitter attack, Eve intercepts the reference pulses emitted by Alice, using Bayesian algorithm to estimate phase shifts.

Structural and antioxidant analysis of Tartary buckwheat (Fagopyrum tartaricum Gaertn.) 13S globulin.

Background: The main component of buckwheat seed storage proteins is 13S globulin. In this study, Tartary buckwheat 13S globulin was separated and its structural features were investigated using Edman sequencing and matrix-assisted laser desorption / ionization time of flight mass spectrometry (MALDI-TOF-MS). The protective effect of its enzymatic hydrolysates against oxidative stress induced by H O was also evaluated to elucidate the antioxidant mechanism.