HSPB8-BAG3 chaperone complex modulates cell invasion in intrahepatic cholangiocarcinoma by regulating CASA-mediated Filamin A degradation.

The incidence of intrahepatic cholangiocarcinoma (ICC) is steadily rising, and it is associated with a high mortality rate. Clinical samples were collected to detect the expression of HSPB8 and BAG3 in ICC tissues. ICC cells were cultured and transfected with plasmids that overexpressed or silenced specific genes to investigate the impact of gene expression alterations on cell function.

Ecotoxicological risk assessment of 14 pesticides and corresponding metabolites to groundwater and soil organisms using China-PEARL model and RQ approach.

Global use of pesticides brings uncertain risks to human and nontarget species via environmental matrix. Currently, various models for exposure risk assessment are developed and widely used to forecast the impact of pesticides on environmental organisms. In this study, five commonly used insecticides, seven herbicides and three fungicides were chosen to analyze the subsequent risks in groundwater in simulated scenarios using China-PEARL (Pesticide Emission Assessment at Regional and Local Scales) model.

Molecular Mechanisms of in Prevention and Treatment of Non-Small-Cell Lung Cancer.

Objective: Lung cancer represents the leading cause of cancer death on a global scale. (), a traditional medicinal material with a high medicinal and health value, has recently been reported for its anticancer activity. However, the pharmacological mechanism of in non-small-cell lung cancer (NSCLC) remains to be elucidated.

Toxicity and risk assessment of nine pesticides on nontarget natural predator Harmonia axyridis (Coleoptera: Coccinellidae).

Background: Harmonia axyridis (Coleoptera: Coccinellidae) is a beneficial predatory arthropod in the agricultural ecosystem. For the success and development of integrated pest management strategies, it is essential to assess the toxicity risks of commonly used pesticides to nontarget arthropods.

Results: The glass tube residue method was used to determine the risk of nine pesticides to H.

Comparative sensitivity of Neoseiulus cucumeris and its prey Tetranychus cinnabarinus, after exposed to nineteen pesticides.

The toxicity tests of nineteen commonly used pesticides were carried out to compare the sensitivity differences between predatory mite Neoseiulus cucumeris and its prey Tetranychus cinnabarinus by a "leaf spray method" in laboratory microcosms. For two avermectins, emamectin benzoate and abamectin, exhibited high bioactivity against T. cinnabarinusf with LR values of 0.

Function Analysis of P450 and GST Genes to Imidacloprid in (Koch).

(Koch) is an economically important pest that affects legumes in worldwide. Chemical control is still the primary efficient method for management. However, the mechanism underlying insecticide resistance in has not been elucidated.

Sublethal and transgenerational effects of acetamiprid and imidacloprid on the predatory bug Orius sauteri (Poppius) (Hemiptera: Anthocoridae).

The predatory bug Orius sauteri (Poppius) is currently one of the most important beneficial arthropods in Northeast Asia and used as a biological control agent of several small pest arthropods including Frankliniella occidentalis (Pergande). Two neonicotinoid chemical insecticides, acetamiprid and imidacloprid, mainly used in China as chemical control on F. occidentalis, although applied at sublethal concentrations in the field or greenhouse to protect beneficial arthropods, still may affect the predator O.

Efficient Degradation of Phenoxyalkanoic Acid Herbicides by the Alkali-Tolerant Strain X32.

Phenoxyalkanoic acid (PAA) herbicides are mainly metabolized by microorganisms in soils, but the degraders that perform well under alkaline environments are rarely considered. Herein, we report strain X32, which showed encouraging PAA-degradation abilities, PAA tolerance, and alkali tolerance. In liquid media, without the addition of exogenous carbon sources, X32 could completely remove 500 mg/L 2,4-dichlorophenoxyacetic acid (2,4-D) or 4-chloro-2-methylphenoxyacetic acid within 3 days, faster than that with the model degrader JMP134.

Effects of toxic β-glucosides on carbohydrate metabolism in cotton bollworm, Helicoverpa armigera (Hübner).

The purpose of this study was to evaluate the effects of three toxic β-glucosides, phlorizin, santonin, and amygdalin, on carbohydrate metabolism in the cotton bollworm, Helicoverpa armigera (Hübner), when diets mixed with β-glucosides were fed to third-instar larvae. The growth of the larvae was significantly inhibited by exposure to santonin after 96 hr but not obviously affected by phlorizin and amygdalin. The midgut trehalase activities were only 51.

Overexpression of forkhead box M1 is associated poor survival in patients with nonsmall cell lung cancer.

Aims: The association between forkhead box M1 (FOXM1) and survival of nonsmall cell lung cancer (NSCLC) has been extensively investigated. However, the results were conflicted and inconclusive. Therefore, we performed this meta-analysis to precisely estimate the association between FOXM1 and survival of NSCLC.

Comparative susceptibility of thirteen selected pesticides to three different insect egg parasitoid Trichogramma species.

The parasitoid Trichogramma species are indispensable natural enemies of many lepidopterans and it plays an important role in integrated pest management (IPM) programs throughout the world. Laboratory studies were conducted to compare the susceptibility of three Trichogramma egg parasitoid species to ten common insecticides and three herbicides. The adults of Trichogramma dendrolimi, T.

Effects of acetamiprid on life cycle development of predatory mite Amblyseius cucumeris (Acari: Phytoseiidae) after contact exposure.

Amblyseius cucumeris (Oudemans) is a beneficial non-target arthropod (NTA) and a key predator of pest mites in integrated pest management (IPM) programs across china. The toxic effects of insecticides have been extensively reported on predatory mites, but few studies devoted to the toxicity of compounds to A. cucumeris.

Toxicity of six insecticides to predatory mite Amblyseius cucumeris (Oudemans) (Acari: Phytoseiidae) in- and off-field.

Amblyseius cucumeris (Oudemans) is a beneficial non-target arthropod (NTA) and a key predator of tetranychid mites in integrated pest management (IPM) programs across China. Evaluating the toxic effects of insecticides on such predatory mites is essential for the success and development of IPM. We tested six insecticides to determine the risk of neonicotinoid insecticide toxicity to predatory mites, using the 'open glass plate method' and adult female A.

Comparison of Two Acute Toxicity Test Methods for the Silkworm (Lepidoptera: Bombycidae).

Silkworm (Bombyx mori) is an economically important insect and an ideal nontarget organism to study the environmental assessment of pesticides. Two acute toxicity test methods, leaf-dipping and quantitative spraying, with five insecticides, were compared for pesticide risk assessment. Based on LC50 values of these insecticides by both methods, the order of toxicity levels of five insecticides tested against silkworm was as follows: emamectin benzoate>lambda-cyhalothrin>imidacloprid>chlorpyrifos>dimethoate.

Impact of imidacloprid on life-cycle development of Coccinella septempunctata in laboratory microcosms.

Long-term effects of a single application of imidacloprid on ladybird beetle, Coccinella septempunctata L., were studied in indoor laboratory microcosms, starting with the 2nd instar larvae of C. septempunctata but covering the full life cycle.

Toxic effects of hexaflumuron on the development of Coccinella septempunctata.

Studying the toxic risk of pesticide exposure to ladybird beetles is important from an agronomical and ecological perspective since larval and adult ladybirds are dominant predators of herbivorous pest insects (e.g., aphids) in various crops in China.

Effects of the fungicide metiram in outdoor freshwater microcosms: responses of invertebrates, primary producers and microbes.

The ecological impact of the dithiocarbamate fungicide metiram was studied in outdoor freshwater microcosms, consisting of 14 enclosures placed in an experimental ditch. The microcosms were treated three times (interval 7 days) with the formulated product BAS 222 28F (Polyram®). Intended metiram concentrations in the overlying water were 0, 4, 12, 36, 108 and 324 μg a.

Acute toxicity of the pesticide methomyl on the topmouth gudgeon (Pseudorasbora parva): mortality and effects on four biomarkers.

In this study, the acute toxicity of the pesticide methomyl on the topmouth gudgeon (Pseudorasbora parva) was evaluated using mortality and the activity of the enzymes acetylcholinesterase (AChE), glutathione S-transferases (GSTs), glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) as endpoints. LC50 values were 1.228, 0.