Molecular and clinical characterization of atypical central neurocytomas: implications for diagnosis and treatment strategies.

Objectives: This study aimed to investigate the histological and molecular characteristics of atypical central neurocytomas (CNs) and evaluate their clinical treatment outcomes, with the aim of identifying reliable biomarkers for differentiation and optimal treatment strategies.

Methods: We conducted a retrospective study including 61 patients diagnosed with CNs. Clinical data, neuroimaging, and pathological findings were analyzed.

Effect of Nutritional Intervention on Energy Intake in Head and Neck Cancer Patients After Radiotherapy.

Objective: This study aimed to analyze the impact of nutritional intervention during radiotherapy for head and neck tumors and its effects on energy intake, consumption, and nutritional status.

Methods: A comparative or observational study was conducted, and a total of 103 head and neck tumor patients undergoing radiotherapy were selected for this study and divided into two groups. The control group (n = 51) received routine nursing intervention, while the observation group (n = 52) received additional nutritional intervention.

Construction of a Diagnostic Model for Small Cell Lung Cancer Combining Metabolomics and Integrated Machine Learning.

Background: To date, no study has systematically explored the potential role of serum metabolites and lipids in the diagnosis of small cell lung cancer (SCLC). Therefore, we aimed to conduct a case-cohort study that included 191 cases of SCLC, 91 patients with lung adenocarcinoma, 82 patients with squamous cell carcinoma, and 97 healthy controls.

Methods: Metabolomics and lipidomics were applied to analyze different metabolites and lipids in the serum of these patients.

Boosting immunotherapy of triple negative breast cancer through the synergy of mild PTT and Fe-loaded organosilica nanoparticles.

Triple negative breast cancer (TNBC) is associated with drug resistance, metastasis, and poor immune response. The development of novel strategies to evoke a robust immune response against TNBC is necessary. In this study, we propose a TNBC tumor immunotherapy modality by synergizing nanocatalytic medicine with mild photothermal therapy.

Metastases of basal-like breast invasive ductal carcinoma to the endometrium: A case report and review of the literature.

We present a case of single endometrial metastasis from breast invasive ductal cancer. This case was unique because the immunohistochemical staining was negative for human epidermal growth factor receptor 2/neu and estrogen and progesterone receptors, and positive for cytokeratin 5/6 and epidermal growth factor receptor in the primary and metastatic tumor cells. No gross evidence of tumor was observed in other sites.

Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies.

Traumatic brain injury (TBI) is a major health and socioeconomic problem throughout the world. It is a complicated pathological process that consists of primary insults and a secondary insult characterized by a set of biochemical cascades. The imbalance between a higher energy demand for repair of cell damage and decreased energy production led by mitochondrial dysfunction aggravates cell damage.

The selective ablation of inflammation in an acute stage of ischemic stroke may be a new strategy to promote neurogenesis.

Ischemic stroke is one of the most common diseases in the world. Pre-clinical studies have proved that stem cell therapy is effective in treating ischemic stroke. But there is a "time window" for stem cell therapy that is only limited in acute/subacute stage after stroke.