Predicting the clinical subcutaneous absorption rate constant of monoclonal antibodies using only the primary sequence: a machine learning approach.

Subcutaneous injections are an increasingly prevalent route of administration for delivering biological therapies including monoclonal antibodies (mAbs). Compared with intravenous delivery, subcutaneous injections reduce administration costs, shorten the administration time, and are strongly preferred from a patient experience point of view. An understanding of the absorption process of a mAb from the injection site to the systemic circulation is critical to the process of subcutaneous mAb formulation development.

Surface Curvature and Aminated Side-Chain Partitioning Affect Structure of Poly(oxonorbornenes) Attached to Planar Surfaces and Nanoparticles of Gold.

Cationic amphiphilic polymers are often used to coat nanoparticles as they increase chemical stability in solution and exhibit membrane disruption activities. Among these, poly(oxonorbornenes) (PONs) are tunable membrane disruptors. They can be constructed with either one amine-terminated side chain and one hydrophobic alkyl side chain (PON-50) or two amine-terminated side chains (PON-100) on each repeat unit and can then be conjugated to gold nanoparticles using O-(2-carboxyethyl)-O'-(2-mercaptoethyl) heptaethylene glycol (HEG) spacers.

Antioxidant migration resistance of SiO layer in SiO/PLA coated film.

As novel materials for food contact packaging, inorganic silicon oxide (SiO) films are high barrier property materials that have been developed rapidly and have attracted the attention of many manufacturers. For the safe use of SiO films for food packaging it is vital to study the interaction between SiO layers and food contaminants, as well as the function of a SiO barrier layer in antioxidant migration resistance. In this study, we deposited a SiO layer on polylactic acid (PLA)-based films to prepare SiO/PLA coated films by plasma-enhanced chemical vapour deposition.