Publications by authors named "Rongguang Peng"
Significance of Thyroid Stimulating Immunoglobulin and Thyrotropin Receptor Antibody in Graves' Disease.
J Clin Endocrinol Metab
December 2024
Article Synopsis
- TSI and TRAb are important biomarkers for diagnosing Graves' disease (GD), but their clinical impact needs further exploration.
- A study analyzed medical records to understand the relationship between these antibodies, thyroid function, and relapse rates in GD patients.
- Results showed a strong correlation between TSI and TRAb, and patients with positive TSI levels had a higher risk of relapse after stopping antithyroid drugs, suggesting that negative levels of both antibodies indicate better outcomes.
Background: Germline DICER1 mutations cause familial multinodular goiter (MNG). However, the prevalence of somatic DICER1 mutations in non-MNG benign thyroid nodules and their characteristics remain unknown.
Methods: Adult-onset thyroid nodules with a pathological diagnosis were genotyped via targeted sequencing.
Context: Supplemental methotrexate (MTX) may affect the clinical course of Graves' disease (GD).
Objective: Evaluate efficacy of add-on MTX on medical treatment in GD.
Design: Prospective, open-label, randomized supplementation controlled trial.