Chemopreventive potential of goniothalamin in diethylnitrosamine-induced hepatocellular carcinoma through the suppression of P13K/AKT signalling pathway.

Liver cancer is the most lethal form of cancer and carries a high risk of death around the world. Goniothalamin (GTN) is a styryl-lactone that possesses antiproliferative and apoptotic activity. The molecular action of GTN is not yet fully evaluated.

Molasses-based in situ bio-sequestration of Cr(VI) in groundwater under flow condition.

The in situ biosequestration of Cr(VI) in groundwater with molasses as the carbon source was studied based on column experiments and model simulation in this study. Compared with biological reduction, molasses-based chemical reduction did not cause significant Cr(VI) removal at molasses concentration as high as 1.14 g L.

Microbial interaction patterns and nitrogen cycling regularities in lake sediments under different trophic conditions.

Exploring how nitrogen (N) cycling microbes interact in eutrophic lake sediments and how biogenic elements influence the nitrogen cycle is crucial for understanding biogeochemical cycles and nitrogen accumulation mechanisms. In this study, sediment samples were collected from various areas of Taihu Lake with different trophic conditions in all four seasons from 2015 to 2017. Using high-throughput sequencing and molecular ecological network analysis, we investigated the microbial interaction patterns and the role of nitrogen cycling in sediments from lakes with different trophic conditions.

Investigation and prediction of the biotoxicity of Cu to Chlorella vulgaris: modification of the biotic ligand model.

The increased copper ion (Cu) concentrations in aquatic ecosystem significantly influence the environmental quality and ecosystem safety, while information on the Cu biotoxicity to aquatic microorganisms and the models for biotoxicity prediction are still unclear. In this study, the toxicities of Cu to Chlorella vulgaris under different environmental conditions (e.g.

Association of weight-adjusted-waist index with asthma prevalence and the age of first asthma onset in United States adults.

Objective: The objective of this study was to assess whether the weight-adjusted-waist index(WWI) is associated with the prevalence of asthma and age when first asthma onset appears in US adults.

Methods: For analysis we selected participants from the National Health and Nutrition Examination Survey(NHANES)database between 2001 and 2018. A dose-response curve was calculated using logistic regression,subgroup analysis,and a dose-response curve.

Spatiotemporal distribution, partitioning behavior and flux of per- and polyfluoroalkyl substances in surface water and sediment from Poyang Lake, China.

Thirty-five legacy and emerging per- and polyfluoroalkyl substances (PFAS) were analyzed in surface water and sediments collected from Poyang Lake, the largest freshwater lake in China. The ƩPFAS concentrations ranged from 23 to 1000 ng/L in water dissolved phase, 1.3-9.

Metagenomics-based antibiotic resistance genes diversity and prevalence risk revealed by pathogenic bacterial host in Taihu Lake, China.

In recent decades, antibiotics and antibiotic resistance genes (ARGs) have been regarded as emerging pollutants. In Taihu Lake, as a typical representative of freshwater system in China, the ARGs occurrence and abundance was of great importance for ecological risk control and public health protection. In this research, high-throughput sequencing and metagenomics technique were used to investigate the seasonal ARGs profile in overlying water and sediment at typical area of Taihu Lake.

Characterization and biological evaluation of a novel silver nanoparticle-loaded collagen-chitosan dressing.

Effective coverage and protection is a priority in wound treatment. Collagen and chitosan have been widely used for wound dressings due to their excellent biological activity and biocompatibility. Silver nanoparticles (AgNPs) have a powerful antibacterial effect.

[Principles of "ecological living water" to purify sewage and its application in black and smelly water treatment of Yangzhou].

To explore the fundamental way of black and odorous water treatment, based on the study of the purification function of natural water body and the analysis of root cause and direct cause of black and odorous water body, we elaborated the scientific connotation and ecological function of "ecological living water", and fully revealed the scientific principle and technical advantages of "ecological living water" for sewage treatment. "Ecological living water" was the original ecological water control in situ. Through the rapid water reaeration, the micro-ecosystem of living water was created.

Effect of wheat-maize straw return on the fate of nitrate in groundwater in the Huaihe River Basin, China.

Straw return is becoming a routine practice in disposing of crop residues worldwide. However, the potential effect of such operation on the chemistry of local groundwater is not well documented. Here, shallow groundwater in an area where wheat-maize straw return is practiced was analyzed, and the seasonal changes in the nitrate concentration and the isotope compositions of NO and HO were determined along two flow paths.

Illumina sequencing-based analysis of sediment bacteria community in different trophic status freshwater lakes.

Sediment bacterial community is the main driving force for nutrient cycling and energy transfer in aquatic ecosystem. A thorough understanding of the community's spatiotemporal variation is critical for us to understand the mechanisms of cycling and transfer. Here, we investigated the sediment bacterial community structures and their relations with environmental factors, using Lake Taihu as a model system to explore the dependence of biodiversity upon trophic level and seasonality.

Bone marrow-derived mesenchymal stem cell transplantation ameliorates oxidative stress and restores intestinal mucosal permeability in chemically induced colitis in mice.

Background: Ulcerative colitis (UC) can be viewed as an autoimmune disease. Bone marrow-derived mesenchymal stem cells (MSCs) with its regenerative, cellular multi-lineage and immunomodulatory abilities can influence the repair of damaged tissues in UC. This study investigated the effects of MSCs transplantation on the mice intestinal barrier in response to oxidative stress injury.

[Study of the Raman spectrum of CCl4 Fermi resonance].

Fermi resonance is a very common phenomenon in molecule vibration spectra, especially in polyatomic molecule with complex structure. Fermi resonance appears when a fundamental vibration frequency lies closely to an overtone or combination frequencies. One can observe two peaks coming from Fermi resonance and the energy transfer also occurs between the two peaks.

Poly(allylamine)-encapsulated water-soluble CdSe nanocrystals.

Water-soluble CdSe nanocrystal/poly(allylamine) clusters with sizes ranging between 50 and 200 nm were prepared using 3-amino-1-propanol as a compatibilizing agent. Photoluminescence (PL) quantum yields (QY) up to 20% were achieved in water without the need to clad these CdSe nanocrystals (NCs) with higher band gap inorganic layers. The polymer-to-nanocrystal ratio plays an important role in the internal structure and stability of these polymer/NC clusters, as determined by static and dynamic light scattering in conjunction with PL studies.

Redox-assisted asymmetric ostwald ripening of CdSe dots to rods.

The redox-assisted asymmetric Ostwald ripening of dots to rods was observed upon annealing a concentrated dispersion of CdSe nanocrystals (NCs) containing 0.1 M CdCl2 in 3-amino-1-propanol (APOL)/H2O (v/v = 9/1) at 135 degrees C. Transmission electron microscopic investigation, along with UV-vis and photoluminescence results, revealed that, while the length of these NCs increased upon annealing, their diameter remained constant.

Amine-assisted facetted etching of CdSe nanocrystals.

The treatment of CdSe nanocrystals (NCs) in a 3-amino-1-propanol (APOL)/water (v/v = 10:1) mixture at 80 degrees C in the presence of O(2) causes them to undergo a slow chemical etching process, as evidenced by spectroscopic and structural investigations. Instead of the continuous blue shift expected from a gradual decrease in NC dimensions, a bottleneck behavior was observed with distinct plateaus in the peak position of photoluminescence (PL) and corresponding maxima in PL quantum yield (i.e.

[Advance of Research on Treatment of Donor Lymphocyte Infusions in Relapse of Hematologic Malignancies after Allogeneic Bone Marrow Transplantation].

The applications of allogeneic bone marrow transplantation (allo-BMT) are limited by the high risk of relapse with primary malignancy. The newly adaptive immunotherapy with donor lymphocyte infusions (DLI) can induce an effective graft-versus-leukemia (GVL) reaction leading to molecular remission and prolonged disease free survival in the majority of patients with relapse of CML and some other hematologic malignancies. Little is known about the mechanisms and the kinetics of GVL, however, increasing evidences show that in the case of existence of chimerism the mature donor T lymphocytes are activated by the specific leukocyte artigen presented in the surface of host antigen presenting cells (APC), resulting in exclusively elimination of leukocyte.

[The distribution feature of TCR Vbeta repertoire in peripheral blood T cells from patients with Ph(+) and Ph(-) CML].

To investigate the T cell distribution characters of TCR Vbeta repertoire in Ph(+) and Ph(-) CML. The 24 subfamilies of the TCR Vbeta genes were amplified in peripheral blood T cells from 13 patients with CML (Ph+ b3a2, 5 cases; Ph+ b2a2, 5 cases; Ph(-), 3 cases) by RT-PCR, to analyze the usage of Vbeta subfamilies in different CML patients. The results showed that the expression pattern of Vbeta repertoire was different in normal individuals and in patients with CML which only have part of Vbeta subfamily T cells.

[Study on clonal proliferation of TCR Vbeta subfamily T cells induced by AML-M(2a) cells in vivo and in vitro].

To observe the expression and clonal expansion of TCR Vbeta subfamily T cells induced by AML-M(2a) cells in vivo and in vitro, complementary determining region 3 (CDR3) of TCR beta with variable region genes was amplified by using RT-PCR in both peripheral blood mononuclear cells (PBMNC) and T cells from mixed lymphocyte and tumor culture (MLTC) from four AML-M(2a) patients. The positive products were further analyzed to identify the clonality of T cells by genescan. The results showed that the similarity distribution of TCR Vbeta subfamily T cells was found Vbeta in PBMNC and MLTC.

Clonal expansion T cells identified in acute monoblastic leukemia by CDR3 size analysis of TCR V beta repertoire using RT-PCR and genescan.

Objective: To investigate the distribution and clonality of T cell receptor (TCR) V beta repertoire in patients with acute monoblastic leukemia (AML-M5).

Methods: Expression of the TCR V beta repertoire was analyzed using reverse transcription-polymerase chain reaction (RT-PCR), which amplified the complementarity determining region 3 of 24 TCR V beta genes in peripheral blood from 9 cases with acute myclogenous leukemia subtype 5 or acute monoblastic leukemia (AML-M5). PCR products were further studied by genescan analysis to identify T cell clonality.