How is helping behavior regulated in the brain?

In humans and other animals, individuals can actively respond to the specific needs of others. However, the neural circuits supporting helping behaviors are underspecified. In recent work, Zhang, Wu, and colleagues identified a new role for the anterior cingulate cortex (ACC) in the encoding and regulation of targeted helping behavior (allolicking) in mice.

Mapping brain circuits for murine maternal behavior triggered by pup calls.

How sensory cues are integrated at the level of neural circuits to drive maternal behaviors remains incompletely understood. In a recent study, Valtcheva, Issa, and colleagues identified a previously unknown role for the posterior intralaminar (PIL) nucleus of the thalamus within the neural networks that mediate maternal behavior in mice induced by pup calls.

Neural control of affiliative touch in prosocial interaction.

The ability to help and care for others fosters social cohesiveness and is vital to the physical and emotional well-being of social species, including humans. Affiliative social touch, such as allogrooming (grooming behaviour directed towards another individual), is a major type of prosocial behaviour that provides comfort to others. Affiliative touch serves to establish and strengthen social bonds between animals and can help to console distressed conspecifics.

An amygdala-to-hypothalamus circuit for social reward.

Social interactions and relationships are often rewarding, but the neural mechanisms through which social interaction drives positive experience remain poorly understood. In this study, we developed an automated operant conditioning system to measure social reward in mice and found that adult mice of both sexes display robust reinforcement of social interaction. Through cell-type-specific manipulations, we identified a crucial role for GABAergic neurons in the medial amygdala (MeA) in promoting the positive reinforcement of social interaction.

Cortical Representations of Conspecific Sex Shape Social Behavior.

A central question related to virtually all social decisions is how animals integrate sex-specific cues from conspecifics. Using microendoscopic calcium imaging in mice, we find that sex information is represented in the dorsal medial prefrontal cortex (dmPFC) across excitatory and inhibitory neurons. These cells form a distributed code that differentiates the sex of conspecifics and is strengthened with social experience.

Sexually Dimorphic Control of Parenting Behavior by the Medial Amygdala.

Social behaviors, including behaviors directed toward young offspring, exhibit striking sex differences. Understanding how these sexually dimorphic behaviors are regulated at the level of circuits and transcriptomes will provide insights into neural mechanisms of sex-specific behaviors. Here, we uncover a sexually dimorphic role of the medial amygdala (MeA) in governing parental and infanticidal behaviors.