Publications by authors named "Rongfang Tu"
Article Synopsis
- The study investigates how p-Cresol sulfate (PCS) affects primary biliary cholangitis (PBC) by analyzing serum samples from PBC patients compared to healthy individuals, focusing on amino acid levels and inflammatory markers.
- It utilizes gas chromatography-mass spectrometry (GC-MS) for detecting differences and conducts in vivo experiments with mice to explore the impact of PCS on liver inflammation and Kupffer cell behavior.
- Results indicate that while tyrosine and phenylalanine levels increase, PCS levels drop in PBC, but PCS can still reduce inflammation in damaged bile duct cells, suggesting dietary interventions could be a potential treatment for PBC.
Influences of Two FEV Reference Equations (GLI-2012 and GIRH-2017) on Airflow Limitation Classification Among COPD Patients.
Int J Chron Obstruct Pulmon Dis
September 2022
Objective: To explore the clinical effects of different forced expiratory volume in 1s (FEV) reference equations on chronic obstructive pulmonary disease (COPD) airflow limitation (AFL) classification.
Methods: We conducted a COPD screening program for residents over 40 years old from 2019 to 2021. All residents received the COPD screening questionnaire (COPD-SQ) and spirometry.
In recent years, immune checkpoint inhibitors were successfully introduced to various of cancer therapy. Pembrolizumab, an antibody to programmed cell death-1 (PD-1), which is was approved for treatment of any adult or pediatric, unresectable or metastatic solid tumor. However, just as chemotherapeutics, immune checkpoint inhibitors have many side effects, which are named as immune-related adverse events.
View Article and Find Full Text PDF[Effects of simvastatin on pulmonary fibrosis and endothelial - mesenchymal transition in the pulmonary fibrosis tissue of rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
September 2021
Article Synopsis
- The study aimed to evaluate the impact of simvastatin on pulmonary fibrosis in rats, specifically looking at markers of fibrosis and vascular integrity (VE-cadherin, vimentin, and alpha-SMA).
- A total of 60 male rats were divided into four groups: one control group, one fibrosis group (bleomycin treated), and two simvastatin treatment groups (5 mg and 10 mg).
- Results showed that simvastatin significantly reduced fibrosis markers and increased VE-cadherin levels compared to the fibrosis group, particularly at the highest dose (10 mg) after 28 days of treatment.
[The expression of 5-HTR2B、E-cad、α-SMA in the pulmonary fibrosis in rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
April 2016
Objective: To observe the expression of 5-Hydroxytryptamine 2B receptor (5-HTR2B)、E-cadherin (E-cad)、alpha-smooth muscle actin(α-SMA) in the bleomycin -induced pulmonary fibrosis tissue of rats.
Methods: Forty-five healthy male SD rats were randomly di-vided into control group,bleomycin group and bleomycin+prednisone group(=15). Five rats in each group randomly sacrificed at the 7、the 14 and the 28 day after eastablishing models.