Identification of key genes affecting ventilator-induced diaphragmatic dysfunction in diabetic mice.

Background: Mechanical ventilation (MV) is often required in critically ill patients. However, prolonged mechanical ventilation can lead to Ventilator-induced diaphragmatic dysfunction (VIDD), resulting in difficulty in extubation after tracheal intubation, prolonged ICU stay, and increased mortality. At present, the incidence of diabetes is high in the world, and the prognosis of diabetic patients with mechanical ventilation is generally poor.

Trifluoperazine reduces apoptosis and inflammatory responses in traumatic brain injury by preventing the accumulation of Aquaporin4 on the surface of brain cells.

Currently, no specific and standard treatment for traumatic brain injury (TBI) has been developed. Therefore, studies on new therapeutic drugs for TBI treatment are urgently needed. Trifluoperazine (TFP) is a therapeutic agent for the treatment of psychiatric disorders that reduces edema of the central nervous system.

A comparative study on postoperative mortality prediction of SFLI scoring system and Child-Pugh classification in patients with hepatocellular carcinoma.

Purpose: In our previous study, we have established the clinical significance of the SFLI (scoring formula of liver injury), the purpose of this study was to compare the SFLI system and the Child-Pugh grading system in the prediction of postoperative mortality in patients with hepatocellular carcinoma (HCC).

Methods: 114 patients with HCC who underwent surgical treatment were enrolled. According to the requirement of the indicators for the Child-Pugh classification, various indices (including albumin [ALB], total bilirubin [TBIL], prothrombin time [PT], ascites, and hepatic encephalopathy) were considered in these patients before surgery, and then Child-Pugh grading was performed.

VX680 suppresses the growth of HepG2 cells and enhances the chemosensitivity to cisplatin.

VX680 is an Aurora A inhibitor. It has been reported to inhibit the growth of the HepG2 cell line in several studies. However, whether it enhances chemosensitivity to cisplatin remains unclear.

Clinical significance of a scoring formula of liver injury for the preoperative evaluation of patients with liver cirrhosis.

Objective: The aim of this study was to establish a clinical scoring formula of liver injury (SFLI) using the matter element analysis method, in order to provide the necessary information for the preoperative assessment and treatment of liver cirrhosis in clinical practice.

Materials And Methods: We collected preoperative information for 12 serum biochemical markers (ALB, PA, TBil, SCr, INR, ALT, AST, γ-GT, ALP, PT, APTT, and TT) from patients with liver cirrhosis, statistically analyzed the relationship between the serum biochemical markers and the extent of liver injury, and obtained the liver injury scoring formula using the matter element analysis method.

Results: In our formula, the serum biochemical markers of patients with different degrees of liver cirrhosis damage led to different R-values, which represented the severity of the disease and the liver functional reserve.