Publications by authors named "Rongbo Yan"
Scoulerine: A natural isoquinoline alkaloid targeting SLC6A3 to treat RCC.
Biomed Pharmacother
November 2024
Article Synopsis
- * The substance reduces viability in specific RCC cell lines (769-P and 786-O) in a dose- and time-dependent manner, while increasing apoptosis linked to the Bax protein and inhibiting the MAPK signaling pathway.
- * Bioinformatics revealed SLC6A3 as a promising target of scoulerine, with experiments confirming that scoulerine may induce apoptosis in RCC cells by targeting SLC6A3 and affecting the MAPK pathway, highlighting its potential as a treatment option.