Objective: To evaluate the therapeutic effects of strontium-89 on osseous metastases of prostate cancer by bone scanning and bone alkaline phosphatase (B-AKP) measurement.
Methods: One week before and within 6 months after strontium-89 therapy, bone scanning and B-AKP measurement were performed in 73 patients with bone metastases of prostate cancer. 1.
Zhonghua Zhong Liu Za Zhi
January 2004
Objective: To investigate the efficacy and toxicity of recombinant humanized anti-Her-2/neu antibody (Herceptin) and Taxol for patients with Her-2/neu overexpressing metastatic breast cancer.
Methods: Sixty patients with Her-2/neu overexpressing metastatic breast cancer were investigated. Of the 60 cases, 22 were treated with Herceptin and Taxol and 38 with Taxol and doxorubicin.
Di Yi Jun Yi Da Xue Xue Bao
March 2004
Di Yi Jun Yi Da Xue Xue Bao
January 2004
Objective: To investigate the expressions of serum S100 protein and tissue polypeptide-specific antigen (TPS) in breast cancer and their clinical implications.
Methods: Using enzyme-linked immunosorbent assay, the levels of serum S100 protein and TPS were determined in 48 breast cancer patients as well as in 92 control subjects.
Results: The median level of serum S100 protein and TPS were 0.
Di Yi Jun Yi Da Xue Xue Bao
December 2003
Objective: To evaluate the clinical efficacy and adverse effects of Photofrin photodynamic therapy (PDT) in patients with advanced cancers.
Methods: Forty patients with advanced cancers in stage IV with lumen obstruction, who failed to respond positively to other treatment regimens, received intravenous administration of Photofrin as the photosensitizer at the dose of 2 mg/kg.b.
Di Yi Jun Yi Da Xue Xue Bao
October 2003
Objective: To investigate the relationship between the survival time and the high-expression of epidermal growth factor receptor (EGFR) and human epidermal receptor 2 (HER2) in breast cancer patients, and assess the feasibility of using the two markers either alone or in combination for predicting the prognosis of the patients.
Methods: Breast cancer samples were obtained from 185 patients and measured for the expressions of EGFR and HER-2 by way of immunohistochemistry, and 120 patients (64.9%) were followed up and their survival time recorded.
Di Yi Jun Yi Da Xue Xue Bao
October 2003
Objective: To observe the efficacy of navelbine combined with ifosfamide and cisplatin in the treatment of advanced breast cancer.
Methods: Forty cases of pathologically confirmed stages III-IV breast cancer were treated with combined chemotherapy including intravenously infused navelbine (25 mg/m2, days 1 and 8), ifosfamide (1.3 g/m2, days 1 to 5) and cisplatin (20 mg/m2, days 1-5), administered in cycles of 21 days.
Di Yi Jun Yi Da Xue Xue Bao
September 2003
Objective: To explore appropriate therapy with traditional Chinese medicine for radiation pulmonary injury.
Methods: On the basis of the features of its pathogenesis and development, clinical manifestations, and laboratory findings, the radiation-induced lung injuries were classified into latent, acute and progressive stages, and different treatment principles were applied accordingly. For the injuries in the latent phase, the treatment was administered to promote the vital energy and nourish Yin, and also to moisten the lung and relieve the coughing.
Di Yi Jun Yi Da Xue Xue Bao
September 2003
Objective: To explore the clinical significance of serum erythropoietin (EPO) detection in patients with cancer-related anemia for improving the life quality of the cancer patients in advanced stage with repeated chemotherapy.
Method: The serum EPO levels were determined in 38 cases of cancer-related anemia with enzyme-linked immunosorbent assay (ELISA).
Results: In 24 patients, the serum EPO level was elevated above the normal range, and lowered EPO level was detected in only 1 cases.
Di Yi Jun Yi Da Xue Xue Bao
August 2003
Objective: To investigate the expression of serum tissue polypeptide-specific antigen (TPS) in breast cancer patients and its clinical value in such cases.
Methods: Altogether 160 subjects (90 patients with breast cancer, 40 with benign breast lesions, and 30 healthy subjects) were enrolled in this study. The serum TPS and CA153 levels were measured by ELISA in all the subjects.
Objective: To investigate the relationship between the survival time and the expressions of progesterone receptor (PR) and HER2 in the tumor tissues of patients with breast cancer, thereby to explore the possibility of using the 2 indices as the indicator for the prognosis of the patients.
Method: Immunohistochemical staining for PR and HER2 was performed on paraffin embedded tumor specimens obtained from 185 patients with breast cancer, and follow-up studies were conducted and the survival time of the patients recorded.
Results: In the 120 patients (64.
Zhonghua Zhong Liu Za Zhi
November 2002
Objective: To evaluate the efficacy and drug-related toxicity of combined gemcitabine, cisplatin, and prednisone for the treatment of patients with relapsed or refractory aggressive non-Hodgkin's lymphoma (NHL).
Methods: Fifteen patients with histologically confirmed relapsed or refractory aggressive NHL were included in this study. Gemcitabine was given on D1, 8 of a three to four weeks schedule at a dose of 1000 mg/m(2) intravenously over 30 minutes for no less than three cycles, and cisplatin was given on D1-3 at a dose of 25 mg/m(2).
Di Yi Jun Yi Da Xue Xue Bao
February 2003
Objective: To study the diagnostic value of combined detection of 3 tumor markers, namely tissue polypeptide specific antigen (TPS), neuro-specific enolase (NSE) and carcinoembryonic antigen (CEA), in patients with lung cancer.
Methods: The serum levels of TPS, NSE and CEA were determined by enzyme-linked immumosorbent assay in 72 patients with lung cancer and 114 healthy adults.
Results: The levels of the 3 tumor markers in the patient group were significantly higher than those of the healthy control group (P<0.
Di Yi Jun Yi Da Xue Xue Bao
February 2003
Objective: To explore a new method for in vitro culture of mature dendritic cells (DCs) by utilizing the maturation-inducing effect of tumor necrosis factor-alpha(TNF-alpha) on DC precursors.
Methods: Freshly isolated DC precursors (peripheral blood-derived monocytes) were initially cultivated for 4 h in RPMI 1640 supplemented with 10% fetal bovine serum and containing TNF-alpha (200 U/ml), followed by treatment with rhGM-CSF (800 U/ml) and interleukin (IL)-4 (500 U/ml) added into the medium. After 48 and 96 h, the 3 cytokines were simultaneously added to the medium for further culture.
Objective: To study the therapeutic effects of radiotherapy combined with traditional Chinese medicine (TCM) on non-small cell lung cancer (NSCLC).
Methods: Ninety-two patients with NSCLC were randomly divided into combined treatment group (n=50) and radiotherapy group (n=42). The former group was given TCM in combination with radiotherapy, and the latter group received radiotherapy only.
Di Yi Jun Yi Da Xue Xue Bao
December 2002
Objective: To investigate effect of interferon-gamma (IFN-gamma) on Fas expression and Fas-mediated apoptosis in tumor cell lines.
Methods: Fas expression was detected by flow cytometry, and the tumor cell apoptosis evaluated by enzyme-linked immunosorbent assay and AnnexinV staining assay.
Results: All the 4 tumor cell lines used in this study, e.
Objective: To explore the possibility of evaluating the short-term therapeulic effect of radiofrequency ablation (RFA) in cancer treatment by positron emission tomography.
Methods: The radioactivity intensity of the tumor was detected by PET before and after RFA.
Results: Radioactivity blank was observed in all 33 cases with 54 lesions, indicating the elimination of the tumor was destroyed.