AURKA inhibition shows promise as a therapeutic strategy for ARID1A-mutant colorectal cancer.

Purpose: Mutations in ARID1A frequently occur in colorectal cancer (CRC) cells. However, there are currently no clinical treatment options specifically addressing this aberration. The preliminary in vitro experiments revealed a synthetic lethal interaction between ARID1A and Aurora kinase A (AURKA) in colorectal cancer (CRC) cells.

Enhanced antitumor and anti-angiogenic effects of metronomic Vinorelbine combined with Endostar on Lewis lung carcinoma.

Background: Conventional chemotherapy is commonly used to treat non-small cell lung cancer (NSCLC) however it increases therapeutic resistance. In contrast, metronomic chemotherapy (MET) is based on frequent drug administration at lower doses, resulting in inhibition of neovascularization and induction of tumor dormancy. This study aims to evaluate the inhibitory effects, adverse events, and potential mechanisms of MET Vinorelbine (NVB) combined with an angiogenesis inhibitor (Endostar).

[Laparoscopically assisted neovaginaplasty using peritoneum as vaginal mucous substitute].

Objective: To practice a more atraumatic, physiological and aesthetically valued approach of construction for neovagina.

Methods: Laparoscopically using peritoneum as neovagina lining.

Results: From March 2005 to September 2006, this technique was adopted to treat 10 patients whose diagnosis was congenital absence of vagina.

[Effects of the site and method of liposuction on differentiation of human preadipocytes].

Objective: To illustrate the effects of the site and method of liposuction on differentiation of human preadipocytes.

Methods: Forty-two fatty samples were obtained with liposuction, which were then divided into four groups according to operation sites (abdomen, hip or extremity) and the methods (conventional negative-pressure or syringe method). Each sample was treated with collagenase I to release preadipocytes for in vitro culture.

[Mandibular contour sculpture by osteotomy].

Objective: To investigate the method for mandible osteotomy in order to make the mandible of various square face appear harmony.

Methods: According to different types of the mandible, mandible angle osteotomy was performed in combination with mandible edge, mandible half ring osteotomy or chin augmentation.

Results: A total of 312 cases have been treated since 1996.

[Leg re-contouring by using a new technique of partially removing gastrocnemius].

Objective: To evaluate a method to partially remove gastrocnemius for improvement of the contour of the leg.

Methods: Thirteen patients with bulked calf were undergoing the treatment. With a self-designed apparatus, the gastrocnemius was partially removed by placing the device in the muscle through an incision in the popliteal fossa.