RNA N6-methyladenosine is a key step of posttranscriptional modulation that is involved in governing gene expression. The mA modification catalyzed by Mettl3 has been widely recognized as a critical epigenetic regulation process for tumorigenic properties in various cancer cell lines, including bladder cancer. However, the function of Mettl3 in bladder cancer remains largely unknown.
View Article and Find Full Text PDFOvarian cancer is a highly deadly disease, which is often diagnosed at a late stage with metastases. However, most ovarian cancers relapse after surgery combined with platinum-based chemotherapy. Cancer stem cells (CSCs) are stem-like cells that possess high tumorigenic capability and display higher resistant capability against current therapies.
View Article and Find Full Text PDF