Bioactive isocoumarins isolated from a mangrove-derived fungus sp. MGP11.

Two new isocoumarins penicimarins L-M (), along with seven known analogues () were isolated from the mangrove-derived fungus sp. MGP11. Compounds - were established by spectroscopic methods and comparison of their circular dichroism (CD) spectra with the literature.

One new ,-unsaturated 7-ketone sterol from the mangrove-derived fungus sp.MGF222.

A new ,-unsaturated 7-ketone sterol, 5,6-epoxy-3, 15-dihydroxy-(22,24)-ergosta-8(14),22-dien-7-one (), along with five known sterone derivatives, 5,6-epoxy-3,7-dihydroxy-(22,24)-ergosta-8(14),22-dien-15-one (), 5,6-epoxy-3,7,9-trihydroxy-(22,24)-ergosta-8(14),22-dien-15-one (), 3,9,15-trihydroxy-(22,24)-10(5→4)-abeo-ergosta-6,8(14),22-trien-5-one (), 3,15-dihydroxyl-(22,24)-ergosta-5,8(14),22-trien-7-one () and (22,24)-ergosta-4,6,8(14),22-tetraen-3,15-dione () were isolated from the mangrove-derived fungus sp. MGF222. Their structures were established on the basis of extensive spectroscopic data and comparison with the data of literature.

A new phenol derivative isolated from mangrove-derived fungus sp. HJ002.

A new phenol derivative, 3-chloro-5-hydroxy-4-methoxyphenylacetic acid methyl ester (), along with five known compounds methyl 4-hydroxyphenylacetate (), cytosporone B (), ()-striatisporolide A (), ()-butanedioic acid () and ergosterol () were isolated from the mangrove-derived fungus sp. HJ002. Their structures were established by spectroscopic methods, GIAO based C NMR chemical shift calculations and comparison with the data of literature.

Bioactive Secondary Metabolites from the Culture of the Mangrove-Derived Fungus HJ004.

Two new polyketides, 8--methylnodulisporin F () and nodulisporin H (), two new naphthoquinones, 5-hydroxy-2-methoxy-6,7-dimethyl-1,4-naphthoquinone () and 5-hydroxy-2-methoxynaphtho[9-]furan-1,4-dione (), and a new naphthofuran 1,3,8-trimethoxynaphtho[9-]furan (), along with five known compounds 4--methyl eleutherol (), 2-acetyl-7-methoxybenzofuran (), (-)-orthosporin (), diaporthin (), and 6-hydroxymellein (), were obtained from the EtOAc extract of the mangrove-derived fungus HJ004. The structures of the isolated compounds were elucidated by extensive NMR and MS analyses, while the absolute configurations of the stereogenic carbons were established based on experimental and calculated electronic circular dichroism spectra. Compounds and displayed a potent inhibitory activity against -glucosidase with the IC values of 5.

Bioactive Polyketide Derivatives from the Mangrove-Derived Fungus HJ004.

Five new tetralones, daldiniones A-E (-), three new chromones, 7-hydroxy-5-methoxy-2,3-dimethylchromone (), 5-methoxy-2-propylchromone (), and 7-ethyl-8-hydroxy-6-methoxy-2,3-dimethylchromone (), and two new lactones, helicascolides D and E ( and ), together with nine known metabolites (-, -, and -) were isolated from the mangrove-derived fungus HJ004. The structures and absolute configurations of the new compounds were determined by analyzing MS and NMR data and utilizing GIAO based C NMR chemical shift calculations and quantum chemical electronic circular dichroism (ECD) calculations. Compounds , , and showed inhibitory activities against α-glucosidase with IC values of 13, 15, and 16 μM, respectively.

Bioactive Lactones from the Mangrove-Derived Fungus sp. TGM112.

Three new lactones penicilactones A-C (-) were obtained from the mangrove-derived fungus sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo(OAc)-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy.

Bioactive Meroterpenoids and Isocoumarins from the Mangrove-Derived Fungus Penicillium sp. TGM112.

Two new meroterpenoids, penicianstinoids A and B (1 and 2), and eight new isocoumarins, peniciisocoumarins A-H (3-10), together with 10 known analogues (11-20) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. The structures and absolute configurations of 1-10 were determined by interpretation of detailed NMR, MS spectroscopic data, X-ray diffraction analyses, modified Mosher's method, and calculated electronic circular dichroism data.

Two new benzophenones and one new natural amide alkaloid isolated from a mangrove-derived Fungus Penicillium citrinum.

Two new compounds penibenzophenones A-B (1-2), and the synthetic α,β-unsaturated amide alkaloid (E)-tert-butyl(3-cinnamamidopropyl)carbamate (4), newly identified as a natural product, alone with three known ones (3, 5-6) were isolated from the EtOAc extract of the endophytic fungus Penicillium citrinum HL-5126 isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Compound 1 was a chlorinated benzophenone.