Publications by authors named "Rong-Fang Qiao"
The crosstalk of Wnt/β-catenin signaling and p53 in acute kidney injury and chronic kidney disease.
Kidney Res Clin Pract
November 2024
Wnt/β-catenin is a signaling pathway associated with embryonic development, organ formation, cancer, and fibrosis. Its activation can repair kidney damage during acute kidney injury (AKI) and accelerate the occurrence of renal fibrosis after chronic kidney disease (CKD). Interestingly, p53 has also been found as a key modulator in AKI and CKD in recent years.
View Article and Find Full Text PDFRenal fibrosis is a common pathological feature of chronic kidney disease (CKD) with various etiologies, which seriously affects the structure and function of the kidney. Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily and plays a critical role in regulating the genes related to xenobiotic and endobiotic metabolism in mammals. Previous studies show that PXR is expressed in the kidney and has protective effect against acute kidney injury (AKI).
View Article and Find Full Text PDFArticle Synopsis
- Spinal cord injury (SCI) leads to significant tissue damage and neurological issues, and the study explores the role of Pregnane X receptor (PXR) in this context.
- Using a mouse model, researchers found that PXR expression decreases after SCI, and knocking out PXR improved motor function while reducing apoptosis, inflammation, and oxidative stress.
- The study suggests that PXR activation hampers recovery by downregulating heme oxygenase-1 (HO-1) and inhibiting the NRF2/HO-1 pathway, showing its crucial role in motor function recovery post-SCI.