A New Strategy for Obesity Treatment: Revealing the Frontiers of Anti-obesity Medications.

Obesity dramatically increases the risk of type 2 diabetes, fatty liver, hypertension, cardiovascular disease, and cancer, causing both declines in quality of life and life expectancy, which is a serious worldwide epidemic. At present, more and more patients with obesity are choosing drug therapy. However, given the high failure rate, high cost, and long design and testing process for discovering and developing new anti-obesity drugs, drug repurposing could be an innovative method and opportunity to broaden and improve pharmacological tools in this context.

Feeding-induced hepatokines and crosstalk with multi-organ: A novel therapeutic target for Type 2 diabetes.

Hyperglycemia, which can be caused by either an insulin deficit and/or insulin resistance, is the main symptom of Type 2 diabetes, a significant endocrine metabolic illness. Conventional medications, including insulin and oral antidiabetic medicines, can alleviate the signs of diabetes but cannot restore insulin release in a physiologically normal amount. The liver detects and reacts to shifts in the nutritional condition that occur under a wide variety of metabolic situations, making it an essential organ for maintaining energy homeostasis.

[Screening and identification of a strain and optimization of its phosphate solubilizing capacity].

In order to solve the problem that soil soluble phosphorus content in most cultivated land in China is insufficient and the plant growth is inhibited, a phosphate solubilizing microorganism (PB) was screened and identified, and its phosphate solubilizing performance was optimized. The results showed that the PB strain was belonged to . It had the ability of nitrogen fixation and indole-3-acetic acid (IAA) secretion, as well as a certain inhibitory effect on .

Potential mechanism of Ziyin Tongluo Formula in the treatment of postmenopausal osteoporosis: based on network pharmacology and ovariectomized rat model.

Background: Amending from ancient classic, Ziyin Tongluo Formula (ZYTLF) has been prescribed to treat postmenopausal osteoporosis (PMOP) for decades with good curative effect. However, the possible mechanisms of it are still unknown.

Methods: Ovariectomized rat model was established to validate the therapeutic effect of ZYTLF on PMOP by Micro-CT bone analysis and pathological observation.

Optical properties of monolayer bismuthene in electric fields.

Optical excitations of monolayer bismuthene present very rich and unique absorption spectra. The optical energy gap corresponding to the threshold frequency is not equal to an indirect energy gap, and it becomes zero under the critical electric field. The frequency, number, intensity, and form of the absorption structures are dramatically changed when an external electric field is applied.

Prediction of Quantum Anomalous Hall Effect in MBi and MSb (M:Ti, Zr, and Hf) Honeycombs.

The abounding possibilities of discovering novel materials has driven enhanced research effort in the field of materials physics. Only recently, the quantum anomalous hall effect (QAHE) was realized in magnetic topological insulators (TIs) albeit existing at extremely low temperatures. Here, we predict that MPn (M =Ti, Zr, and Hf; Pn =Sb and Bi) honeycombs are capable of possessing QAH insulating phases based on first-principles electronic structure calculations.

Optical properties of monolayer tinene in electric fields.

The absorption spectra of monolayer tinene in perpendicular electric fields are studied by the tight-binding model. There are three kinds of special structures, namely shoulders, logarithmical symmetric peaks and asymmetric peaks in the square-root form, corresponding to the optical excitations of the extreme points, saddle points and constant-energy loops. With the increasing field strength, two splitting shoulder structures, which are dominated by the parabolic bands of 5p orbitals, come to exist because of the spin-split energy bands.

Landau subband and Landau level properties of AA-stacked graphene superlattice.

Magneto-electronic properties of AA-stacked graphene superlattice (simple hexagonal graphite) are studied by the tight-binding model with an exact diagonalization method. The Landau subbands (LSs) with strong energy dispersions exist along k(z) and each subband possesses two band-edge states. Density of states reflects main features of the LSs, such as asymmetric prominent peak structures and the semimetallic behavior.

Low-energy Landau level spectrum in ABC-stacked trilayer graphene.

The low-lying Landau level (LL) properties of ABC-stacked trilayer graphene are investigated by the tight-binding (TB) model. The LL spectra exhibit an asymmetric structure around the Fermi level and three finely split LLs close to the Fermi level. The LL wave functions are described by six magnetic TB Bloch functions associated with six sublattices.

Optical absorption spectra in finite double-walled carbon nanotubes.

The tight-binding model and the modified gradient approximation are, respectively, used to calculate the electronic states and optical properties of finite double-walled carbon nanotubes (DWCNTs). The optical absorption spectra allow us to decompose the total DWCNT spectral function into the contributions from the inner and outer walls. Intertube interactions can cause drastic changes in the symmetry of the electronic states, the Fermi level, the energy spacing, and the state degeneracy.