ROA: A Rapid Learning Scheme for Memristor Networks.

Memristors show great promise in neuromorphic computing owing to their high-density integration, fast computing and low-energy consumption. However, the non-ideal update of synaptic weight in memristor devices, including nonlinearity, asymmetry and device variation, still poses challenges to the learning of memristors, thereby limiting their broad applications. Although the existing offline learning schemes can avoid this problem by transferring the weight optimization process into cloud, it is difficult to adapt to unseen tasks and uncertain environments.

Effect of Acupoint Embedding on Serum Leptin and Hypothalamus Leptin Receptor Expression in Rats with Simple Obesity.

Background: Acupoint embedding treatment on obesity has been applied in clinical practice for many years and has achieved obvious efficacy. However, animal experimental studies on acupoint embedding are relatively few, and its mechanism remains unclear.

Methods: We established a simple obese rat model using a high-fat diet for 8 weeks.

Identification and validation of a hypoxia-related prognostic signature in clear cell renal cell carcinoma patients.

Increasing evidence has shown that hypoxia is closely related to the development, progression, and prognosis of clear cell renal cell carcinoma (ccRCC). Nevertheless, reliable prognostic signatures based on hypoxia have not been well-established. This study aimed to establish a hypoxia-related prognostic signature and construct an optimized nomogram for patients with ccRCC.

Acupuncture treatment on attention deficit hyperactivity disorder: A protocol for systematic review and meta-analysis.

Background: Attention Deficit Hyperactivity Disorder (ADHD) is the most common behavioral disorder in childhood. Acupuncture treatment of ADHD has formed a relatively systematic theoretical and clinical treatment system which achieved satisfactory results. However, there has been no systematic evaluation of its effectiveness and safety.

Hydrogeochemistry, identification of hydrogeochemical evolution mechanisms, and assessment of groundwater quality in the southwestern Ordos Basin, China.

Understanding the evolution process of hydrogeochemistry and groundwater quality is essential for water supply and health in the southwestern Ordos Basin, where groundwater is a vital source for drinking. This study systematically illustrates the hydrogeochemical characteristics and evolution mechanism based on the groundwater samples (n = 67) collected from Loess area by integrating multivariate statistical methods and hydrogeochemical methods. Furthermore, the entropy water quality index (EWQI) and water quality indices combined with spatial analysis were employed to evaluate the suitability of groundwater for drinking and irrigation purposes and analyze the spatial variation of water quality.

Clinical learning environment, supervision and nurse teacher scale (CLES+T): Psychometric evaluation of the Chinese version.

Background: Clinical learning environment plays a vital role in nursing clinical education. The Clinical Learning Environment, Supervision and Nurse Teacher (CLES+T) scale is a reliable and valid instrument to evaluate the quality of the clinical learning process in international nursing education contexts.

Objectives: To validate the Chinese version of the CLES+T scale that is in line with the Chinese culture and educational context.

Coupling analysis on ecological environment fragility and poverty in South China Karst.

Ecological environment and poverty have a strong spatial coupling. It is of great significance to study the interaction mechanism between them for ecological restoration and targeted poverty alleviation in ecologically fragile areas. Taking Guizhou Plateau, the center of South China Karst, as a research object, this study constructs a multi-dimensional poverty and ecological vulnerability coupling index system and analyses the coupling relationship between ecological environment and poverty from a village scale, using the comprehensive coupling coordination degree model and hot spot analysis method, followed by classifying the types of poverty villages.

Flavivirus: From Structure to Therapeutics Development.

Flaviviruses are still a hidden threat to global human safety, as we are reminded by recent reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections in Brazil. Therapeutic drugs or vaccines for flavivirus infections are in urgent need but are not well developed. The Flaviviridae family comprises a large group of enveloped viruses with a single-strand RNA genome of positive polarity.

Copper on charcoal: Cu nanoparticle catalysed aerobic oxidation of α-diazo esters.

By using a charcoal supported nano Cu catalyst (Cu/C), a highly efficient oxidation of α-diazo esters to α-ketoesters with molecular oxygen as the sole oxidant has been developed. In the presence of the Cu/C catalyst, 2-aryl-α-diazo esters with both electron-donating and electron-withdrawing groups can be oxidized to the corresponding α-ketoesters efficiently. Furthermore, this Cu/C catalyst can catalyse the reaction of aryl α-diazo ester with water to form aryl ketoester, 2-aryl-2-hydroxyl acetate ester and 2-aryl acetate ester.

Relationship Between Proactive Personality and Job Performance of Chinese Nurses: The Mediating Role of Competency and Work Engagement.

As one of the main participants in health care, nurses are esteemed an important driving force for the vigorous health care development. Studies report that nurses' proactive personality has positive effects on their job performance; however, this relationship acquires further understanding. A cross-sectional study was performed to explore the relationship between nurses' proactive personality and job performance; the mediating role of nurses' competency and work engagement in this relationship was also evaluated.

The complete mitochondrial genome of Decne. (Asteraceae, Falc.).

The complete mitochondrial genome of was sequenced for the first time. The mitochondrial genome length was 320,439 bp, with 45.05% GC contents.

MiRNA-based model for predicting the TMB level in colon adenocarcinoma based on a LASSO logistic regression method.

Some patients with advanced colon adenocarcinoma (COAD) are not sensitive to radiotherapy and chemotherapy, and as such, immunotherapy has become the most popular option for these patients. However, different patients respond differently to immunotherapy. Tumor mutational burden (TMB) has been used as a predictor of the response of advanced COAD patients to immunotherapy.

Aurora kinase inhibitor VX-680 enhances sensitivity of esophageal squamous cell carcinoma cells to cisplatin chemotherapy.

Esophageal squamous cell carcinoma (ESCC) is malignant cancer with a high mortality rate. Cisplatin is one of the most potent chemotherapy agents used in the treatment of ESCC. However, chemoresistance and severe adverse effects of cisplatin become major obstacles to clinical utility.

Novel Biallelic Variations Cause Multiple Morphological Abnormalities of the Sperm Flagella.

Sperm motility is vital to human reproduction, and malformed sperm flagella can cause male infertility. Individuals with multiple morphological abnormalities of the flagella mostly have absent, short, coiled, bent, and/or irregular-caliber flagella. In this study, a patient with male infertility underwent a physical examination along with his wife.

CaO/FeO nanocomposites for oxygen-independent generation of radicals and cancer therapy.

The hypoxic tumor environment prevents the generation of reactive oxygen species (ROS), reducing the therapeutic efficiency. We construct oleylamine (OA) coated CaO/FeO nanocomposites to realize oxygen-independent generation of ROS and high efficient treatment of cancer. In the tumor site, CaO reacts with water to generate HO, which can be catalized by Fe that is produced by FeO, to form highly toxic hydroxyl radicals (∙OH).

Prediction of Disease Progression of COVID-19 Based upon Machine Learning.

Background: Since December 2019, COVID-19 has spread throughout the world. Clinical outcomes of COVID-19 patients vary among infected individuals. Therefore, it is vital to identify patients at high risk of disease progression.

Eyes grow towards mild hyperopia rather than emmetropia in Chinese preschool children.

Purpose: To document one-year changes in refraction and refractive components in preschool children.

Methods: Children, 3-5 years old, in the Jiading District, Shanghai, were followed for one year. At each visit, axial length (AL), refraction under cycloplegia (1% cyclopentolate), spherical dioptres (DS), cylinder dioptres (DC), spherical equivalent refraction (SER) and corneal curvature radius (CR) were measured.

Floating solid-state thin films with dynamic structural colour.

Thin-film architectures are a staple in a wide range of technologies, such as semiconductor devices, optical coatings, magnetic recording, solar cells and batteries. Despite the industrial success of thin-film technology, mostly due to the easy fabrication and low cost, a fundamental drawback remains: it is challenging to alter the features of the film once fabricated. Here we report a methodology to modify the thickness and sequence of the innermost solid-state thin-film layers.

Research progress regarding potential effects of traditional Chinese medicine on postoperative intestinal obstruction.

Objectives: Postoperative intestinal obstruction is a common postoperative complication with typical symptoms of abdominal pain, vomiting, abdominal distension and constipation. The principal aim of this paper is to provide a full-scale review on the categories and characteristics of postoperative intestinal obstruction, pathophysiology, effects and detailed mechanisms of compounds and monomers from traditional Chinese medicine for treating postoperative intestinal obstruction. Moreover, the possible development and perspectives for future research are also analyzed.

The complete mitochondrial genome of Rchb. (Ranales, Ranunculaceae).

Rchb. is a medicinal plant in the Ranunculaceae family. In this study, we report the first complete mitochondrial genome of .

SPARC-related modular calcium binding 1 regulates aortic valve calcification by disrupting BMPR-II/p-p38 signalling.

Aims: Aortic valve calcification is more prevalent in chronic kidney disease accompanied by hypercalcemia. Secreted protein acidic and rich in cysteine (SPARC)-related modular calcium binding 1 (SMOC1) is a regulator of BMP2 signalling, but the role of SMOC1 in aortic valve calcification under different conditions has not been studied. This study aimed to investigate the roles of SMOC1 in aortic valve calcification under normal and high calcium conditions, focusing on the effects on aortic valve interstitial cells (AVICs).

Natural Medicines for the Treatment of Epilepsy: Bioactive Components, Pharmacology and Mechanism.

Epilepsy is a chronic disease that can cause temporary brain dysfunction as a result of sudden abnormal discharge of the brain neurons. The seizure mechanism of epilepsy is closely related to the neurotransmitter imbalance, synaptic recombination, and glial cell proliferation. In addition, epileptic seizures can lead to mitochondrial damage, oxidative stress, and the disorder of sugar degradation.

PLCG2 as a potential indicator of tumor microenvironment remodeling in soft tissue sarcoma.

The tumor microenvironment (TME) plays an important role in the occurrence and development of soft tissue sarcoma (STS). A number of studies have shown that to inhibit tumor growth, the TME can be remodeled into an environment unsuitable for tumor proliferation. However, a lack of understanding exists regarding the dynamic regulation of TME.