Cu- and P-co-doped nitrogen-doped hierarchical carbon for enhanced oxygen reduction reaction in zinc-air batteries.

High-performance Fe-based nitrogen-doped carbon oxygen reduction catalysts have been widely reported, but the Fenton reaction faced by such catalysts has hindered their practical application in fuel cells. The development of inexpensive, effective, and durable non-Fe nitrogen-doped carbon electrocatalysts is important for advancing fuel cell technology. In this work, we have introduced a molecular coordination chemistry method to synthesize a Cu- and P-co-doped nitrogen-doped hierarchical carbon (Cu-P-N-C) oxygen reduction reaction (ORR) electrocatalyst by pyrolyzing a mixture of phytate and melamine.

Oil pollution risks on coastlines in the Eastern China Seas.

As maritime transportation experiences continuous development, the escalating potential risk of oil spills necessitates thorough and detailed risk assessments. Realizing the inherent contingency and unpredictability of oil spill incidents, this study employs a 3D oil spill model combining with long-term hydro-meteorological data to evaluate the oil pollution risk (OPR) along the coastlines of the Eastern China Seas. Through simulations spanning four seasons over 21 years (2001-2021), diverse scenarios are captured.

Nanozyme-Catalyzed Colorimetric Microfluidic Immunosensor for the Filtration Enrichment and Ultrasensitive Detection of in Food Samples.

Rapid screening of foodborne pathogens is crucial to prevent food poisoning. In this study, we proposed a nanozyme-catalyzed colorimetric microfluidic immunosensor (Nano-CMI) for the filtration enrichment and ultrasensitive detection of in complex matrices. Gold-core porous platinum shell nanopompoms (Au@Pt nanopompoms) were synthesized with excellent peroxidase-like activity to oxidize 3,3',5,5'-tetramethylbenzidine with significant color change.

PPDPF-mediated regulation of BCAA metabolism enhances mTORC1 activity and drives cholangiocarcinoma progression.

Tumor cells display profound changes in the metabolism of branched-chain amino acids (BCAA). However, how these changes are regulated to facilitate tumorigenesis is not yet completely understood. Here, we identified pancreatic progenitor cell differentiation and proliferation factor (PPDPF) as a BCAA-responsive protein through extensive screening using stable isotope labeling with amino acids in cell culture (SILAC).

HfZrO-based synaptic resistor circuit for a Super-Turing intelligent system.

Computers based on the Turing model execute artificial intelligence (AI) algorithms that are either programmed by humans or derived from machine learning. These AI algorithms cannot be modified during the operation process according to environmental changes, resulting in significantly poorer adaptability to new environments, longer learning latency, and higher power consumption compared to the human brain. In contrast, neurobiological circuits can function while simultaneously adapting to changing conditions.

Reno protective potential of taxifolin liposomes modified by chitosan in diabetic mice.

The objective of this study was to develop chitosan-modified taxifolin liposomes (CTL) to enhance the treatment of diabetic kidney injury in mice and to address the limitations of taxifolin (TAX) solubility and bioavailability. Taxifolin liposomes (TL) were fabricated via film dispersion and subsequently modified with chitosan to obtain CTL. Characterisation analyses confirmed the successful construction of the liposomes.

Inflammasome mediated in situ cancer vaccine activated by schottky heterojunction for augmented immunotherapy.

In situ cancer vaccines have emerged as an attractive paradigm for cancer immunotherapy. Nevertheless, insufficient antigens production, weak antigen presentation and immunosuppressive tumor microenvironment impeded the effectiveness of tumor immunotherapy. Herein, we constructed the NLRP3 inflammasome mediated in situ cancer vaccine (FPLB), in which rod shaped α-FeO@Pt schottky heterojunction loaded with lactate oxidase (LOx) and surface-modified with bovine serum albumin and folic acid conjugation (FA-BSA).

Transcriptome analysis reveals hypoxic response key genes and modules as well as adaptive mechanism of crucian carp () gill under hypoxic stress.

Fish gill tissue is a primary organ responsive to acute oxygen deprivation or dissolved oxygen (DO) fluctuations in aquatic environments. However, the adaptive mechanism of crucian carp to hypoxic stress remains largely unknown. Here, we investigated gill physiological and transcriptomic changes of crucian carp exposed to hypoxic conditions (dissolved oxygen concentration of 0.

Two-Dimensional Nanozyme-Catalyzed Colorimetric CRISPR Assay for the Microfluidic Detection of Monkeypox Virus.

The recent monkeypox epidemic outbreaks worldwide highlight the urgent need for fast and precise diagnostic solutions, especially in resource-limited settings. Here, a two-dimensional nanozyme-catalyzed colorimetric CRISPR assay for the microfluidic detection of the monkeypox virus (MPXV) was established. We utilized graphene oxide as a substrate for the adsorption of gold seeds and the deposition of a porous Pt shell to prepare high-performance two-dimensional GO@Pt nanomaterials.

Advancements in nanoparticles-based therapeutic approaches for osteosarcoma: Insights from catechins-modified selenium-doped hydroxyapatite: A review.

Osteosarcoma is common in all age groups, and a multifaceted strategy that includes radiation therapy, surgical intervention and chemotherapy remains the conventional treatment for osteosarcoma. Existing therapies typically result in recurring malignancies and postsurgical bone abnormalities, necessitating novel strategies for targeted drug administration and bone defects. The most significant components that are crucial for maintain strong bones include trace elements, calcium, selenium, and vitamins K and D.

Stable Polyoxometalate-Based Metal-Organic Framework: Synthesis, Modification, and Catalytic Activity.

Metal-organic frameworks (MOFs) with polyoxometalates (POMs) as the nodes usually feature a high stability. Those with available space and modifiable groups are expected to serve as a catalytic platform. In this work, a polyoxometalate-based metal-organic framework (POMOF)-bearing channel with a transversal surface of ca.

Tissue Clearing and Its Application in Nanoparticle Development.

Nanoparticles are widely used in biomedical applications due to their small size, large surface area, and unique physicochemical properties. These characteristics make them ideal for drug delivery, diagnostic imaging, and therapeutic interventions. Their ability to interact with biological systems at the cellular and molecular levels enables targeted treatments.

Temporal shifts in dengue epidemic in Guangdong Province before and during the COVID-19 pandemic: a Bayesian model study from 2012 to 2022.

Background: During the coronavirus disease 2019 (COVID-19) pandemic, the implementation of public health intervention measures have reshaped the transmission patterns of other infectious diseases. We aimed to analyze the epidemiological characteristics of dengue in Guangdong Province, China, and to investigate the temporal shifts in dengue epidemic in Guangdong Province during the COVID-19 pandemic.

Methods: Based on the data of dengue reported cases, meteorological factors, and mosquito vector density in Guangdong Province from 2012 to 2022, wavelet analysis was applied to investigate the relationship between the dengue incidence in Southeast Asian (SEA) countries and the local dengue incidence in Guangdong Province.

Impact of MRI risk assessment on the survival benefits of neoadjuvant chemoradiotherapy in patients with stage II-III rectal cancer: A retrospective cohort study.

Purpose: To investigate whether MRI risk factors can be used to predict clinical outcomes and whether MRI risk assessment can be used to select stage II-III rectal cancer patients who may benefit from neoadjuvant chemoradiotherapy (nCRT).

Methods And Materials: A total of 947 rectal cancer patients who underwent total mesorectal excision (TME) were retrospectively recruited. An MRI scoring system was established using the cumulative score of three risk factors (mesorectal fascia involvement, extramural venous invasion, and tumour deposits).

Transcriptome Sequencing Reveals Effects of Artificial Feed Domestication on Intestinal Performance and Gene Expression of Carnivorous Mandarin Fish (Siniperca chuatsi) and Related Mechanisms.

Mandarin fish (Siniperca chuatsi) is a voracious carnivorous species, usually consuming only live bait fish, but dietary acclimation enables it to accept artificial feed. However, the effects of dietary acclimation on intestinal performance and gene expression in mandarin fish and related mechanisms remain largely unknown. Therefore, this study investigated the effects of artificial feed on intestinal physicochemical and biochemical performance and gene expression in mandarin fish.

Dense stroma activates the TGF-β1/FBW7 axis to induce metabolic subtype switching in pancreatic cancer.

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases. Although several chemotherapy regimens have been developed over the past decades, few targeted therapies have shown a significant improvement in overall survival, partly due to the identification of PDAC as a single disease.

Methods: Combining metabolomic analysis and immunohistochemistry staining with Oil Red O staining, analysis for the oxygen consumption rate and extracellular acidification rate, we stratified pancreatic cancer cells into two subtypes.

Improved Grain Boundary Reconstruction Method Based on Channel Attention Mechanism.

The grain size of metal materials has a significant impact on their macroscopic properties. However, original metallographic images often suffer from issues such as substantial noise, missing grain boundaries, low contrast, and blurred edges. These challenges hinder the accurate extraction of complete grain boundaries, limiting the precision of grain size measurement and material performance prediction.

Nano Delivery System for Atherosclerosis.

Atherosclerosis, a pathological process propelled by inflammatory mediators and lipids, is a principal contributor to cardiovascular disease incidents. Currently, drug therapy, the primary therapeutic strategy for atherosclerosis, faces challenges such as poor stability and significant side effects. The advent of nanomaterials has garnered considerable attention from scientific researchers.

Transcriptomic landscape of Hras12V oncogene-induced hepatocarcinogenesis with gender disparity.

The genesis of hepatocellular carcinoma (HCC) is closely related to male factors and hyper-activated Ras signals. A transcriptomic database was established via RNA-Seq of HCC (T) and the adjacent precancerous liver tissue (P) of Hras12V transgenic mice (Ras-Tg, HCC model) and the normal liver tissue of wild-type mice (W) of both sexes. Comparative analysis within W, P, and T and correlation expression pattern analysis revealed common/unique cluster-enriched items towards HCC between the sexes.

Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning.

Efficient and accurate nanocarrier development for targeted drug delivery is hindered by a lack of methods to analyze its cell-level biodistribution across whole organisms. Here we present Single Cell Precision Nanocarrier Identification (SCP-Nano), an integrated experimental and deep learning pipeline to comprehensively quantify the targeting of nanocarriers throughout the whole mouse body at single-cell resolution. SCP-Nano reveals the tissue distribution patterns of lipid nanoparticles (LNPs) after different injection routes at doses as low as 0.

A novel approach to the prevention and management of chemotherapy-induced cardiotoxicity: PANoptosis.

As a fundamental component of antitumor therapy, chemotherapy-induced cardiotoxicity (CIC) has emerged as a leading cause of long-term mortality in patients with malignant tumors. Unfortunately, there are currently no effective therapeutic preventive or treatment strategies, and the underlying pathophysiological mechanisms of CIC remain inadequately understood. A growing number of studies have shown that different mechanisms of cell death, such as apoptosis, pyroptosis, and necroptosis, are essential for facilitating the cardiotoxic effects of chemotherapy.

Influence of Bonding Temperature on Microstructure and Mechanical Properties of AZ31/Zn/Sn/5083 Diffusion Joint.

Diffusion bonding with an interlayer is considered an effective means of obtaining Mg/Al dissimilar alloy joints. However, at low temperatures, it is often impossible to simultaneously achieve joints between the interlayer and Mg/Al under the same bonding parameters. For this reason, the interlayer is usually prefabricated on the substrate, followed by conducting diffusion bonding.

Clinical Radiologic Analysis of 2964 Papillary Breast Lesions.

Clinical management of papillary breast lesions (PBLs) remains controversial. Our objective was to analyze the independent risk factors associated with malignant PBLs. A retrospective review of clinical variables in 2964 patients with papillary lesions available for evaluation.

Platelet Membrane-Coated HGF-PLGA Nanoparticles Promote Therapeutic Angiogenesis and Tissue Perfusion Recovery in Ischemic Hindlimbs.

Therapeutic angiogenesis has garnered significant attention as a potential treatment strategy for lower limb ischemic diseases. Although hepatocyte growth factor (HGF) has been identified as a key promoter of therapeutic angiogenesis, its clinical application is limited due to its short half-life. In this study, we successfully developed and characterized platelet membrane-coated HGF-poly(lactic--glycolic acid) (PLGA) nanoparticles (NPs).